PMID- 31687230
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 2090-6560 (Print)
IS  - 2090-6579 (Electronic)
IS  - 2090-6579 (Linking)
VI  - 2019
DP  - 2019
TI  - Hemophagocytic Lymphohistiocytosis in an AIDS Patient with Kaposi Sarcoma: A 
      Treatment Dilemma.
PG  - 7634760
LID - 10.1155/2019/7634760 [doi]
LID - 7634760
AB  - Hemophagocytic lymphohistiocytosis (HLH) is a result of an abnormal activation of 
      immune cells (T lymphocytes, natural killer cells, and macrophages) resulting in 
      cytokine overproduction and immune destruction of cells, eventually resulting in 
      multiorgan failure. Genetic causes are responsible for primary hemophagocytosis, 
      but malignancies, infections, and autoimmunity underlie most of the secondary 
      cases. We present an unusual case of a patient with AIDS and disseminated Kaposi 
      sarcoma who was commenced on highly active antiretroviral therapy (HAART) but 
      developed HLH secondary to immune reconstitution inflammatory syndrome (IRIS). We 
      report this case to highlight the difficulty in managing this patient given the 
      complex interplay of immunosuppression due to AIDS, immune reconstitution 
      following initiation of HAART, and immune overdrive manifesting as HLH.
CI  - Copyright (c) 2019 Oluwadunni E. Emiloju et al.
FAU - Emiloju, Oluwadunni E
AU  - Emiloju OE
AUID- ORCID: 0000-0002-6884-4010
AD  - Department of Medicine, Einstein Medical Center, Philadelphia, PA 19141, USA.
FAU - Gupta, Sorab
AU  - Gupta S
AUID- ORCID: 0000-0003-2624-4217
AD  - Department of Hematology and Medical Oncology, Einstein Medical Center, 
      Philadelphia, PA 19141, USA.
FAU - Arguello-Guerra, Vivian
AU  - Arguello-Guerra V
AD  - Department of Pathology and Laboratory Medicine, Einstein Medical Center, 
      Philadelphia, PA 19141, USA.
FAU - Dourado, Claudia
AU  - Dourado C
AD  - Department of Hematology and Medical Oncology, Einstein Medical Center, 
      Philadelphia, PA 19141, USA.
LA  - eng
PT  - Case Reports
DEP - 20191007
PL  - United States
TA  - Case Rep Hematol
JT  - Case reports in hematology
JID - 101576456
PMC - PMC6800897
COIS- The authors have no conflicts of interest to declare regarding the authorship of 
      this case report.
EDAT- 2019/11/07 06:00
MHDA- 2019/11/07 06:01
PMCR- 2019/10/07
CRDT- 2019/11/06 06:00
PHST- 2019/06/26 00:00 [received]
PHST- 2019/09/16 00:00 [accepted]
PHST- 2019/11/06 06:00 [entrez]
PHST- 2019/11/07 06:00 [pubmed]
PHST- 2019/11/07 06:01 [medline]
PHST- 2019/10/07 00:00 [pmc-release]
AID - 10.1155/2019/7634760 [doi]
PST - epublish
SO  - Case Rep Hematol. 2019 Oct 7;2019:7634760. doi: 10.1155/2019/7634760. eCollection 
      2019.