PMID- 31688039 OWN - NLM STAT- MEDLINE DCOM- 20200930 LR - 20200930 IS - 1473-5571 (Electronic) IS - 0269-9370 (Linking) VI - 33 IP - 14 DP - 2019 Nov 15 TI - The proportion of CD57+ cells among effector CD8+ T cells is lower in HIV controllers compared with antiretroviral therapy-treated patients. PG - 2137-2147 LID - 10.1097/QAD.0000000000002342 [doi] AB - BACKGROUND: HIV infection has often been linked to faster immune ageing. We sought to determine whether or not treatment-naive spontaneous HIV-1 controllers (HICs) and ART-exposed patients differ with regard to the expression of cell senescence markers. METHODS: Eighty-eight chronically infected HICs and ART-exposed patients (median time since infection: 15 years) with an undetectable plasma HIV RNA load (at least for the previous 2 years) were included. We used flow cytometry to measure immunosenescence markers (KLRG-1 and CD57) expression in fresh blood samples collected from patients and healthy donors. RESULTS: For the CD8 T-cell population as a whole, the ART-exposed but not the HIC patients exhibited a much higher proportion of KLRG-1 and CD57 CD8 T cells than healthy blood donors. For the CD8 T-cell subsets, HICs had a lower proportion of CD57 effector CD8 T cells than ART patients or healthy blood donors, whereas the proportions of KLRG-1 effector were similar. A similar trend was observed for terminal effectors. No impact of age, sex or standard parameters of infection (CD4 percentage, protective HLA allele, viral blips) was observed. The difference in the proportion of CD57 cells between HICs and ART was observed more specifically in long-term infected patients (>20 years). However, whenever considering the CD57 effector memory and effector subsets, the cytotoxic granule content was greater in HICs than in ART. CONCLUSION: The proportion of CD57 effector CD8 T cells is lower in HICs than in ART-exposed patients. This profile may be beneficial by ensuring limited senescence associated with consistent cytotoxic potential. FAU - Henriquez, Soledad AU - Henriquez S AD - CEA - Universite Paris Sud 11 - INSERM U1184, Immunology of Viral Infections and Autoimmune Diseases, IDMIT Department, IBFJ, Fontenay-aux-Roses. FAU - Lecuroux, Camille AU - Lecuroux C AD - CEA - Universite Paris Sud 11 - INSERM U1184, Immunology of Viral Infections and Autoimmune Diseases, IDMIT Department, IBFJ, Fontenay-aux-Roses. FAU - Bitu, Marie AU - Bitu M AD - CEA - Universite Paris Sud 11 - INSERM U1184, Immunology of Viral Infections and Autoimmune Diseases, IDMIT Department, IBFJ, Fontenay-aux-Roses. FAU - Avettand-Fenoel, Veronique AU - Avettand-Fenoel V AD - Universite Paris Descartes, Faculte de Medecine, Sorbonne Paris Cite. AD - INSERM, U1016, Institut Cochin. AD - CNRS, UMR8104, Paris. AD - Assistance Publique - Hopitaux de Paris, Laboratoire de Microbiologie clinique, Hopital Necker-Enfants Malades. FAU - Churaqui, Francoise AU - Churaqui F AD - CNRS, UMR8104, Paris. FAU - Catalan, Pilartxo AU - Catalan P AD - Assistance Publique-Hopitaux de Paris, Service de Medecine Interne et Immunologie Clinique, Groupe Hospitalier Universitaire Paris Sud, Hopital Bicetre. FAU - Cheret, Antoine AU - Cheret A AD - Universite Paris Descartes, Faculte de Medecine, Sorbonne Paris Cite. AD - INSERM, U1016, Institut Cochin. AD - CNRS, UMR8104, Paris. AD - Assistance Publique-Hopitaux de Paris, Service de Medecine Interne et Immunologie Clinique, Groupe Hospitalier Universitaire Paris Sud, Hopital Bicetre. FAU - Boufassa, Faroudy AU - Boufassa F AD - INSERM CESP U1018, Universite Paris Sud, Paris Saclay. AD - Universite Paris Sud, Le Kremlin Bicetre. FAU - Saez-Cirion, Asier AU - Saez-Cirion A AD - Institut Pasteur, HIV Inflammation et Persistance, Paris. FAU - Monceaux, Valerie AU - Monceaux V AD - Institut Pasteur, HIV Inflammation et Persistance, Paris. FAU - Meyer, Laurence AU - Meyer L AD - INSERM CESP U1018, Universite Paris Sud, Paris Saclay. AD - Universite Paris Sud, Le Kremlin Bicetre. AD - Assistance Publique-Hopitaux de Paris, Service de Sante Publique, Groupe Hospitalier Universitaire Paris Sud, Hopital Bicetre, Le Kremlin-Bicetre, France. FAU - Goujard, Cecile AU - Goujard C AD - Assistance Publique-Hopitaux de Paris, Service de Medecine Interne et Immunologie Clinique, Groupe Hospitalier Universitaire Paris Sud, Hopital Bicetre. AD - INSERM CESP U1018, Universite Paris Sud, Paris Saclay. AD - Universite Paris Sud, Le Kremlin Bicetre. FAU - Lambotte, Olivier AU - Lambotte O AD - CEA - Universite Paris Sud 11 - INSERM U1184, Immunology of Viral Infections and Autoimmune Diseases, IDMIT Department, IBFJ, Fontenay-aux-Roses. AD - Assistance Publique-Hopitaux de Paris, Service de Medecine Interne et Immunologie Clinique, Groupe Hospitalier Universitaire Paris Sud, Hopital Bicetre. AD - Universite Paris Sud, Le Kremlin Bicetre. FAU - Bourgeois, Christine AU - Bourgeois C AD - CEA - Universite Paris Sud 11 - INSERM U1184, Immunology of Viral Infections and Autoimmune Diseases, IDMIT Department, IBFJ, Fontenay-aux-Roses. AD - Universite Paris Sud, Le Kremlin Bicetre. CN - ANRS CO6 PRIMO, the ANRS CO21 CODEX cohorts LA - eng PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - England TA - AIDS JT - AIDS (London, England) JID - 8710219 RN - 0 (CD57 Antigens) SB - IM CIN - AIDS. 2019 Nov 15;33(14):2253-2255. PMID: 31688042 MH - Adult MH - Antiretroviral Therapy, Highly Active MH - CD57 Antigens/*metabolism MH - CD8-Positive T-Lymphocytes/*immunology MH - Female MH - HIV Infections/drug therapy/*immunology MH - HIV-1 MH - Humans MH - Immunophenotyping MH - *Immunosenescence MH - Lymphocyte Count MH - Male MH - Middle Aged MH - T-Lymphocyte Subsets/immunology MH - Viral Load EDAT- 2019/11/07 06:00 MHDA- 2020/10/02 06:00 CRDT- 2019/11/06 06:00 PHST- 2019/11/06 06:00 [entrez] PHST- 2019/11/07 06:00 [pubmed] PHST- 2020/10/02 06:00 [medline] AID - 00002030-201911150-00003 [pii] AID - 10.1097/QAD.0000000000002342 [doi] PST - ppublish SO - AIDS. 2019 Nov 15;33(14):2137-2147. doi: 10.1097/QAD.0000000000002342.