PMID- 31688648
OWN - NLM
STAT- MEDLINE
DCOM- 20201211
LR  - 20210714
IS  - 1530-0315 (Electronic)
IS  - 0195-9131 (Linking)
VI  - 52
IP  - 4
DP  - 2020 Apr
TI  - Baseline and Exercise Predictors of V O2peak in Systolic Heart Failure Patients: 
      Results from SMARTEX-HF.
PG  - 810-819
LID - 10.1249/MSS.0000000000002193 [doi]
AB  - PURPOSE: This study aimed to investigate baseline, exercise testing, and exercise 
      training-mediated predictors of change in peak oxygen uptake (V O2peak) from 
      baseline to 12-wk follow-up (DeltaV O2peak) in a post hoc analysis from the SMARTEX 
      Heart Failure trial. METHODS: We studied 215 patients with heart failure with 
      left ventricular ejection fraction (LVEF) </=35%, and New York Heart Association 
      (NYHA) classes II-III who were randomized to either supervised high-intensity 
      interval training with exercise target intensity of 90%-95% of peak heart rate 
      (HRpeak) or supervised moderate continuous training (MCT) with target intensity 
      of 60%-70% of HRpeak, or who received a recommendation of regular exercise on 
      their own. Predictors of DeltaV O2peak were assessed in two models: a logistic 
      regression model comparing highest and lowest tertiles (baseline parameters) and 
      a multivariate linear regression model (test/training/clinical parameters). 
      RESULTS: The change in V O2peak in response to the interventions (DeltaV O2peak) 
      varied substantially, from -8.50 to +11.30 mL.kg.min. Baseline NYHA (class II 
      gave higher odds vs III; odds ratio (OR), 7.1 (2.0-24.9); P = 0.002), LVEF (OR 
      per percent, 1.1 (1.0-1.2); P = 0.005), and age (OR per 10 yr, 0.5 (0.3-0.8); P = 
      0.003) were associated with DeltaV O2peak.In the multivariate linear regression, 34% 
      of the variability in DeltaV O2peak was explained by the increase in exercise 
      training workload, DeltaHRpeak between baseline and 12-wk posttesting, age, and ever 
      having smoked. CONCLUSION: Exercise training response (DeltaV O2peak) correlated 
      negatively with age, LVEF, and NYHA class. The ability to increase workload 
      during the training period and increased DeltaHRpeak between baseline and the 12-wk 
      test were associated with a positive outcome.
FAU - Karlsen, Trine
AU  - Karlsen T
FAU - Videm, Vibeke
AU  - Videm V
FAU - Halle, Martin
AU  - Halle M
FAU - Ellingsen, Oyvind
AU  - Ellingsen O
FAU - Stoylen, Asbjorn
AU  - Stoylen A
FAU - Dalen, Havard
AU  - Dalen H
FAU - Delagardelle, Charles
AU  - Delagardelle C
AD  - Department of Cardiology, Centre Hospitalier de Luxembourg, LUXEMBOURG.
FAU - Larsen, Alf Inge
AU  - Larsen AI
FAU - Hole, Torstein
AU  - Hole T
FAU - Mezzani, Alessandro
AU  - Mezzani A
AD  - Cardiac Rehabilitation Division, Salvatore Maugeri Foundation IRCCS, Scientific 
      Institute of Veruno, Veruno, ITALY.
FAU - VAN Craenenbroeck, Emeline M
AU  - VAN Craenenbroeck EM
FAU - Beckers, Paul
AU  - Beckers P
FAU - Pressler, Axel
AU  - Pressler A
AD  - Department of Cardiology, Antwerp University Hospital, Edegem, BELGIUM.
FAU - Christle, Jeffrey W
AU  - Christle JW
FAU - Winzer, Ephraim B
AU  - Winzer EB
AD  - Heart Center Dresden, University Hospital at the Technical University of Dresden, 
      Dresden, GERMANY.
FAU - Mangner, Norman
AU  - Mangner N
AD  - Heart Center Dresden, University Hospital at the Technical University of Dresden, 
      Dresden, GERMANY.
FAU - Woitek, Felix J
AU  - Woitek FJ
AD  - Heart Center Dresden, University Hospital at the Technical University of Dresden, 
      Dresden, GERMANY.
FAU - Hollriegel, Robert
AU  - Hollriegel R
AD  - Heart Center Dresden, University Hospital at the Technical University of Dresden, 
      Dresden, GERMANY.
FAU - Snoer, Martin
AU  - Snoer M
AD  - Department of Cardiology, Zeeland University Hospital, Roskilde, DENMARK.
FAU - Feiereisen, Patrick
AU  - Feiereisen P
AD  - Department of Cardiology, Centre Hospitalier de Luxembourg, LUXEMBOURG.
FAU - Valborgland, Torstein
AU  - Valborgland T
FAU - Linke, Axel
AU  - Linke A
FAU - Prescott, Eva
AU  - Prescott E
AD  - Department of Cardiology, Bispebjerg Hospital, University of Copenhagen, 
      Copenhagen, DENMARK.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Med Sci Sports Exerc
JT  - Medicine and science in sports and exercise
JID - 8005433
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Exercise Therapy/*methods
MH  - Exercise Tolerance
MH  - Female
MH  - Heart Failure/classification/*physiopathology/*therapy
MH  - Heart Rate
MH  - High-Intensity Interval Training
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Oxygen Consumption
MH  - Smoking
MH  - Stroke Volume/*physiology
MH  - Ventricular Function, Left/*physiology
EDAT- 2019/11/07 06:00
MHDA- 2020/12/15 06:00
CRDT- 2019/11/06 06:00
PHST- 2019/11/07 06:00 [pubmed]
PHST- 2020/12/15 06:00 [medline]
PHST- 2019/11/06 06:00 [entrez]
AID - 00005768-202004000-00005 [pii]
AID - 10.1249/MSS.0000000000002193 [doi]
PST - ppublish
SO  - Med Sci Sports Exerc. 2020 Apr;52(4):810-819. doi: 10.1249/MSS.0000000000002193.