PMID- 31689583
OWN - NLM
STAT- MEDLINE
DCOM- 20200505
LR  - 20200505
IS  - 1532-2688 (Electronic)
IS  - 1059-1311 (Linking)
VI  - 73
DP  - 2019 Dec
TI  - Are seizures predictors of mortality in critically ill patients in the intensive 
      care unit (ICU)?
PG  - 14-16
LID - S1059-1311(19)30450-9 [pii]
LID - 10.1016/j.seizure.2019.10.009 [doi]
AB  - PURPOSE: This study aimed to determine if seizures in critically ill patients are 
      predictive of in-hospital mortality. METHODS: Patients above the age of 55 who 
      underwent continuous electroencephalogram (cEEG) monitoring between 2015 and 2018 
      at the Hackensack Meridian Health and JFK Neuroscience Institute were included in 
      the present study. Patients were subdivided into those with and without seizures. 
      Age, sex, seizure types, CNS disorders, and other associated comorbidities were 
      collected by chart review. After descriptive analysis, we used multiple logistic 
      regression analyses to evaluate if seizures and mortality were associated. 
      P-values less than 0.05 were considered statistically significant. RESULTS: One 
      hundred and one critically ill patients (62.4% female) were included in this 
      study. Sixty-six (65.3%) were between 55 and 75 years of age, while 35 (34.7%) 
      were above 75 years of age. Most patients (n = 31, 83.8%) had focal-onset 
      seizures, and 10 had nonconvulsive status epilepticus (NCSE). Twelve (11.9%) 
      patients with seizures did not survive. However, seizures were not independently 
      associated with mortality in either unadjusted (OR 1.13, CI 0.47-2.72, p = 0.773) 
      or adjusted (OR 1.20, CI 0.35-4.05, p = 0.760) regression models. Secondary 
      predictors of mortality included mechanical ventilation (OR 5.36, CI 1.69-16.96, 
      p = 0.001) and acute ischemic stroke (OR 2.77, CI 1.08-7.09, p = 0.034). 
      CONCLUSION: Seizures did not predict in-hospital mortality in critically ill 
      patients. Larger prospective studies are needed to confirm our current findings.
CI  - Copyright (c) 2019 British Epilepsy Association. Published by Elsevier Ltd. All 
      rights reserved.
FAU - Silveira, Diosely C
AU  - Silveira DC
AD  - Hackensack Meridian Health and JFK Neuroscience Institute, 65 James Street, 
      Edison NJ 08820, United States. Electronic address: 
      diosely.silveira@hackensackmeridian.org.
FAU - Sagi, Anirudh
AU  - Sagi A
AD  - Stone Brook University, NY, United States.
FAU - Romero, Raquel
AU  - Romero R
AD  - Hackensack Meridian Health and JFK Neuroscience Institute, 65 James Street, 
      Edison NJ 08820, United States.
LA  - eng
PT  - Journal Article
DEP - 20191018
PL  - England
TA  - Seizure
JT  - Seizure
JID - 9306979
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Critical Illness/*mortality
MH  - Female
MH  - *Hospital Mortality
MH  - Humans
MH  - Intensive Care Units
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Seizures/*mortality
OTO - NOTNLM
OT  - Elderly
OT  - Intensive care unit
OT  - Mortality
OT  - Seizures
EDAT- 2019/11/07 06:00
MHDA- 2020/05/06 06:00
CRDT- 2019/11/06 06:00
PHST- 2019/07/02 00:00 [received]
PHST- 2019/10/08 00:00 [revised]
PHST- 2019/10/10 00:00 [accepted]
PHST- 2019/11/07 06:00 [pubmed]
PHST- 2020/05/06 06:00 [medline]
PHST- 2019/11/06 06:00 [entrez]
AID - S1059-1311(19)30450-9 [pii]
AID - 10.1016/j.seizure.2019.10.009 [doi]
PST - ppublish
SO  - Seizure. 2019 Dec;73:14-16. doi: 10.1016/j.seizure.2019.10.009. Epub 2019 Oct 18.