PMID- 31690160
OWN - NLM
STAT- MEDLINE
DCOM- 20210804
LR  - 20220420
IS  - 1525-1489 (Electronic)
IS  - 0885-0666 (Print)
IS  - 0885-0666 (Linking)
VI  - 36
IP  - 3
DP  - 2021 Mar
TI  - Six-Minute Walk Distance After Critical Illness: A Systematic Review and 
      Meta-Analysis.
PG  - 343-351
LID - 10.1177/0885066619885838 [doi]
AB  - BACKGROUND AND OBJECTIVES: Impaired physical functioning is common and long 
      lasting after an intensive care unit (ICU) admission. The 6-minute walk test 
      (6MWT) is a validated and widely used test of functional capacity. This 
      systematic review synthesizes existing data in order to: (1) evaluate 6-minute 
      walk distance (6MWD) in meters over longitudinal follow-up after critical 
      illness, (2) compare 6MWD between acute respiratory distress syndrome (ARDS) 
      versus non-ARDS survivors, and (3) evaluate patient- and ICU-related factors 
      associated with 6MWD. DATA SOURCES: Five databases (PubMed, EMBASE, Cumulative 
      Index of Nursing and Allied Health Literature, PsychINFO, and Cochrane Controlled 
      Trials Registry) were searched to identify studies reporting 6MWT after hospital 
      discharge in survivors from general (ie, nonspeciality) ICUs. The last search was 
      run on February 14, 2018. Databases were accessed via Johns Hopkins University 
      Library. DATA EXTRACTION AND SYNTHESIS: Pooled mean 6MWD were reported, with 
      separate linear random effects models used to evaluate associations of 6MWD with 
      ARDS status, and patient- and ICU-related variables. Twenty-six eligible articles 
      on 16 unique participant groups were included. The pooled mean (95% confidence 
      interval [CI]) 6MWD results at 3- and 12-months post discharge were 361 (321-401) 
      and 436 (391-481) meters, respectively. There was a significant increase in 6MWD 
      at 12 months compared to 3 months (P = .017). In ARDS versus non-ARDS survivors, 
      the mean (95% CI) 6MWD difference over 3-, 6-, and 12-month follow-up was 73 
      [13-133] meters lower. Female sex and preexisting comorbidity also were 
      significantly associated with lower 6MWD, with ICU-related variables having no 
      consistent associations. CONCLUSIONS: Compared to initial assessment at 3 months, 
      significant improvement in 6MWD was reported at 12 months. Female sex, 
      preexisting comorbidity, and ARDS (vs non-ARDS) were associated with lower 6MWT 
      results. Such factors warrant consideration in the design of clinical research 
      studies and in the interpretation of patient status using the 6MWT.
FAU - Parry, Selina M
AU  - Parry SM
AUID- ORCID: 0000-0003-2204-3143
AD  - Department of Physiotherapy, 2281The University of Melbourne, Melbourne, 
      Victoria, Australia.
FAU - Nalamalapu, Swaroopa R
AU  - Nalamalapu SR
AD  - 1499Greater Baltimore Medical Center, Towson, MD, USA.
FAU - Nunna, Krishidhar
AU  - Nunna K
AD  - 23303Sinai Hospital of Baltimore, MD, USA.
FAU - Rabiee, Anahita
AU  - Rabiee A
AD  - Department of Medicine, 12228Yale School of Medicine, New Haven, CT, USA.
FAU - Friedman, Lisa Aronson
AU  - Friedman LA
AD  - Outcomes After Critical Illness and Surgery Group, 1466Johns Hopkins University, 
      Baltimore, MD, USA.
AD  - Division of Pulmonary and Critical Care Medicine, School of Medicine, 1466Johns 
      Hopkins University, Baltimore, MD, USA.
FAU - Colantuoni, Elizabeth
AU  - Colantuoni E
AD  - Outcomes After Critical Illness and Surgery Group, 1466Johns Hopkins University, 
      Baltimore, MD, USA.
AD  - Department of Biostatistics, Bloomberg School of Public Health, 1466John Hopkins 
      University, Baltimore, MD, USA.
FAU - Needham, Dale M
AU  - Needham DM
AD  - Outcomes After Critical Illness and Surgery Group, 1466Johns Hopkins University, 
      Baltimore, MD, USA.
AD  - Division of Pulmonary and Critical Care Medicine, School of Medicine, 1466Johns 
      Hopkins University, Baltimore, MD, USA.
AD  - Department of Physical Medicine and Rehabilitation, School of Medicine, 1466Johns 
      Hopkins University, Baltimore, MD, USA.
FAU - Dinglas, Victor D
AU  - Dinglas VD
AUID- ORCID: 0000-0001-5238-2790
AD  - Outcomes After Critical Illness and Surgery Group, 1466Johns Hopkins University, 
      Baltimore, MD, USA.
AD  - Division of Pulmonary and Critical Care Medicine, School of Medicine, 1466Johns 
      Hopkins University, Baltimore, MD, USA.
LA  - eng
GR  - R24 HL111895/HL/NHLBI NIH HHS/United States
GR  - T32 DK007356/DK/NIDDK NIH HHS/United States
GR  - UL1 TR001863/TR/NCATS NIH HHS/United States
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20191105
PL  - United States
TA  - J Intensive Care Med
JT  - Journal of intensive care medicine
JID - 8610344
SB  - IM
MH  - *Aftercare
MH  - Child
MH  - *Critical Illness
MH  - Female
MH  - Humans
MH  - Intensive Care Units
MH  - Male
MH  - Patient Discharge
MH  - *Walk Test
MH  - Walking
PMC - PMC7442114
MID - NIHMS1608555
OTO - NOTNLM
OT  - 6-minute walk test
OT  - critical illness
OT  - intensive care
OT  - physical function
OT  - physical recovery
COIS- Summary Conflict of Interest statements: No authors had any conflict of interests 
      to declare.
EDAT- 2019/11/07 06:00
MHDA- 2021/08/05 06:00
PMCR- 2022/03/01
CRDT- 2019/11/07 06:00
PHST- 2019/11/07 06:00 [pubmed]
PHST- 2021/08/05 06:00 [medline]
PHST- 2019/11/07 06:00 [entrez]
PHST- 2022/03/01 00:00 [pmc-release]
AID - 10.1177/0885066619885838 [doi]
PST - ppublish
SO  - J Intensive Care Med. 2021 Mar;36(3):343-351. doi: 10.1177/0885066619885838. Epub 
      2019 Nov 5.