PMID- 31690224
OWN - NLM
STAT- MEDLINE
DCOM- 20200303
LR  - 20200303
IS  - 1347-6947 (Electronic)
IS  - 0916-8451 (Linking)
VI  - 84
IP  - 2
DP  - 2020 Feb
TI  - Cryptotanshinone attenuates allergic airway inflammation through negative 
      regulation of NF-kappaB and p38 MAPK.
PG  - 268-278
LID - 10.1080/09168451.2019.1687280 [doi]
AB  - This study is to determine the role and mechanism of cryptotanshinone (CTS) in 
      allergic airway inflammation. Asthma induced by OVA was established in BALB/c 
      mice. We found increased airway hyperresponsiveness (AHR), increased inflammatory 
      cell infiltration, elevated levels of TNF-alpha, interleukin-1beta (IL-1beta), IL-4, IL-5, 
      IL-6 and IL-13, decreased interferon gamma (IFN-gamma) in lung tissue, increased 
      content of total immunoglobulin E (IgE), OVA specific IgE, Eotaxin, ICAM-1, 
      VCAM-1, nuclear factor-kappaB (NF-kappaB) and phosphorylation of p38 MAPK in lung 
      tissue. However, the administration of CTS significantly decreased AHR in 
      asthmatic mice, reduced inflammation around the bronchioles and inflammatory 
      cells around airway, regulated cytokine production, reduced the total IgE and 
      OVA-specific IgE levels, and inhibited NF-kappaB activation and p38 MAPK 
      phosphorylation. In vitro experiments in 16 HBE cells revealed that CTS 
      attenuated CAM-1 and IL-6 expression. These results indicate that CTS alleviates 
      allergic airway inflammation by modulating p38 MAPK phosphorylation and NF-kappaB 
      activation.
FAU - Li, Junfeng
AU  - Li J
AD  - Department of Anatomy, Histology and Embryology, Yanbian University Medical 
      College, Yanji, P.R. China.
FAU - Zheng, Mingyu
AU  - Zheng M
AD  - College of Pharmacy, Yanbian University, Yanji, P.R. China.
FAU - Wang, Chongyang
AU  - Wang C
AD  - Department of Anatomy, Histology and Embryology, Yanbian University Medical 
      College, Yanji, P.R. China.
FAU - Jiang, Jingzhi
AU  - Jiang J
AD  - Department of Anatomy, Histology and Embryology, Yanbian University Medical 
      College, Yanji, P.R. China.
FAU - Xu, Chang
AU  - Xu C
AD  - Department of Anatomy, Histology and Embryology, Yanbian University Medical 
      College, Yanji, P.R. China.
FAU - Li, Li
AU  - Li L
AD  - Department of Anatomy, Histology and Embryology, Yanbian University Medical 
      College, Yanji, P.R. China.
FAU - Li, Liangchang
AU  - Li L
AD  - Department of Anatomy, Histology and Embryology, Yanbian University Medical 
      College, Yanji, P.R. China.
FAU - Yan, Guanghai
AU  - Yan G
AD  - Department of Anatomy, Histology and Embryology, Yanbian University Medical 
      College, Yanji, P.R. China.
FAU - Jin, Yongde
AU  - Jin Y
AD  - Department of Otolaryngology-Head and Neck Surgery, Yanbian University Hospital, 
      Yanji, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20191105
PL  - England
TA  - Biosci Biotechnol Biochem
JT  - Bioscience, biotechnology, and biochemistry
JID - 9205717
RN  - 0 (Cytokines)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (NF-kappa B)
RN  - 0 (Phenanthrenes)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 5E9SXT166N (cryptotanshinone)
RN  - 9006-59-1 (Ovalbumin)
RN  - EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases)
SB  - IM
MH  - Animals
MH  - Asthma/metabolism/*pathology
MH  - Bronchial Hyperreactivity
MH  - Bronchoalveolar Lavage Fluid/cytology
MH  - Chemotaxis, Leukocyte/drug effects
MH  - Cytokines/metabolism
MH  - Drugs, Chinese Herbal
MH  - Female
MH  - Hypersensitivity/metabolism/*pathology
MH  - Immunoglobulin E/metabolism
MH  - Inflammation/metabolism/*pathology
MH  - Lung/metabolism
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - NF-kappa B/*metabolism
MH  - Ovalbumin/toxicity
MH  - Phenanthrenes/*pharmacology
MH  - Phosphorylation
MH  - p38 Mitogen-Activated Protein Kinases/*metabolism
OTO - NOTNLM
OT  - Cryptotanshinone
OT  - NF-kappaB
OT  - airway remodeling
OT  - asthma
OT  - p38 MAPKs
EDAT- 2019/11/07 06:00
MHDA- 2020/03/04 06:00
CRDT- 2019/11/07 06:00
PHST- 2019/11/07 06:00 [pubmed]
PHST- 2020/03/04 06:00 [medline]
PHST- 2019/11/07 06:00 [entrez]
AID - 10.1080/09168451.2019.1687280 [doi]
PST - ppublish
SO  - Biosci Biotechnol Biochem. 2020 Feb;84(2):268-278. doi: 
      10.1080/09168451.2019.1687280. Epub 2019 Nov 5.