PMID- 31690360
OWN - NLM
STAT- MEDLINE
DCOM- 20200831
LR  - 20210402
IS  - 1751-732X (Electronic)
IS  - 1751-7311 (Print)
IS  - 1751-7311 (Linking)
VI  - 14
IP  - 4
DP  - 2020 Apr
TI  - Shearing during late pregnancy increases size at birth but does not alter 
      placental endocrine responses in sheep.
PG  - 799-806
LID - 10.1017/S1751731119002696 [doi]
AB  - Shearing during the latter half of pregnancy is a common practice to improve 
      flock health and productivity. Previous studies have demonstrated that shearing 
      pregnant ewes at mid or late pregnancy is associated with an increase in lamb 
      birth weight. In the present study, we used singleton Polypay x Dorset pregnant 
      sheep, to investigate the potential roles of placental function and changes in 
      maternal metabolism in underlying this increased birth weight response. Two 
      groups were randomly established and blocked at enrollment by animal BW, body 
      condition score and subcutaneous adipose tissue depth. The groups were shorn (SH; 
      n = 18) or not (C; n = 20) at gestational day (GD) 107 +/- 1 (mean +/- SEM). Weekly 
      maternal plasma samples were collected between shearing and birth, but only six 
      samples were assayed for progesterone, pregnancy-associated glycoproteins (PAG1), 
      glucose and non-esterified fatty acids (NEFAs). At birth, sex, birth weight, and 
      newborn body mass index (BMI) were recorded. Maternal BW during mid- to 
      late-pregnancy was similar between groups. Shearing resulted in increased lamb 
      birth weight and BMI (P < 0.05) regardless of fetal sex but did not affect the 
      maternal concentration of PAG1 or progesterone from GDs 100 to 142. After 
      shearing (GD100) and up to lambing, shorn females had higher circulating glucose 
      concentrations (P < 0.05), but not NEFA, compared to the control group. Maternal 
      circulating PAG1, progesterone, glucose or NEFA concentration across pregnancy 
      did not differ according to lamb sex. Across pregnancy, birth weight was 
      positively associated with PAG1 (P < 0.001), but not with progesterone 
      concentrations. In conclusion, weight and BMI at birth were higher in both sexes 
      upon shearing in singleton pregnancies. Despite PAG1 being associated with birth 
      weight, late-pregnancy shearing did not alter the placental endocrine response. 
      Whether other placental factors are altered upon shearing and may influence the 
      increase in birth weight and BMI remain to be investigated.
FAU - Rosales Nieto, C A
AU  - Rosales Nieto CA
AD  - Department of Animal Science, College of Agriculture and Natural Resources, 
      Michigan State University, East Lansing, Michigan 48824, USA.
FAU - Mantey, A
AU  - Mantey A
AD  - Department of Animal Science, College of Agriculture and Natural Resources, 
      Michigan State University, East Lansing, Michigan 48824, USA.
FAU - Makela, B
AU  - Makela B
AD  - Department of Animal Science, College of Agriculture and Natural Resources, 
      Michigan State University, East Lansing, Michigan 48824, USA.
FAU - Byrem, T
AU  - Byrem T
AD  - Antel Biosystems, East Lansing, Michigan 48910, USA.
FAU - Ehrhardt, R
AU  - Ehrhardt R
AD  - Department of Animal Science, College of Agriculture and Natural Resources, 
      Michigan State University, East Lansing, Michigan 48824, USA.
AD  - Department of Large Animal Clinical Sciences, College of Veterinary Medicine, 
      Michigan State University, East Lansing, Michigan 48824, USA.
FAU - Veiga-Lopez, A
AU  - Veiga-Lopez A
AUID- ORCID: 0000-0002-0308-7231
AD  - Department of Animal Science, College of Agriculture and Natural Resources, 
      Michigan State University, East Lansing, Michigan 48824, USA.
LA  - eng
GR  - R01 ES027863/ES/NIEHS NIH HHS/United States
PT  - Journal Article
DEP - 20191106
PL  - England
TA  - Animal
JT  - Animal : an international journal of animal bioscience
JID - 101303270
RN  - 0 (Blood Glucose)
RN  - 0 (Fatty Acids, Nonesterified)
RN  - 0 (Glycoproteins)
RN  - 4G7DS2Q64Y (Progesterone)
SB  - IM
MH  - Animals
MH  - Birth Weight
MH  - Blood Glucose/analysis
MH  - Endocrine System/physiology
MH  - Fatty Acids, Nonesterified/blood
MH  - Female
MH  - Glycoproteins/blood
MH  - Male
MH  - Parturition
MH  - Placenta/physiology
MH  - Pregnancy
MH  - Progesterone/*blood
MH  - Sheep/*physiology
MH  - Wool/physiology
PMC - PMC7082203
MID - NIHMS1555536
OTO - NOTNLM
OT  - birth weight
OT  - body mass index
OT  - glycoproteins
OT  - pregnancy shearing
OT  - progesterone
COIS- Declaration of interest The authors declare no conflict of interest.
EDAT- 2019/11/07 06:00
MHDA- 2020/09/01 06:00
PMCR- 2021/04/01
CRDT- 2019/11/07 06:00
PHST- 2019/11/07 06:00 [pubmed]
PHST- 2020/09/01 06:00 [medline]
PHST- 2019/11/07 06:00 [entrez]
PHST- 2021/04/01 00:00 [pmc-release]
AID - S1751731119002696 [pii]
AID - 10.1017/S1751731119002696 [doi]
PST - ppublish
SO  - Animal. 2020 Apr;14(4):799-806. doi: 10.1017/S1751731119002696. Epub 2019 Nov 6.