PMID- 31690371
OWN - NLM
STAT- MEDLINE
DCOM- 20201105
LR  - 20201105
IS  - 1539-6304 (Electronic)
IS  - 1088-5412 (Linking)
VI  - 40
IP  - 6
DP  - 2019 Nov 1
TI  - Skin testing in allergy.
PG  - 366-368
LID - 10.2500/aap.2019.40.4248 [doi]
AB  - Skin tests are used in addition to a directed history and physical examination to 
      exclude or confirm immunoglobulin E (IgE) mediated diseases, such as allergic 
      rhinitis, asthma, and anaphylaxis, to aeroallergens, foods, insect venoms, and 
      certain drugs. There are two types of skin testing used in clinical practice: 
      percutaneous testing (prick or puncture) and intracutaneous testing 
      (intradermal). Prick testing involves introducing a needle into the upper layers 
      of the skin through a drop of allergen extract that has been placed on the skin 
      and gently lifting the epidermis up. Various devices are available for prick 
      testing. Intracutaneous (intradermal) testing involves injecting a small amount 
      of allergen into the dermis. The release of preformed histamine from mast cells 
      causes increased vascular permeability via smooth-muscle contraction and 
      development of a wheal; inflammatory mediators initiate a neural reflex, which 
      causes vasodilatation, which leads to erythema (the flare). Prick testing methods 
      are the initial technique for detecting the presence of IgE. These may correlate 
      better with clinical sensitivity and are more specific but less sensitive than 
      intradermal testing. Sites of skin testing include the back and the volar aspect 
      of the arm. By skin testing on the arm, the patient can witness the emergence and 
      often sense the pruritus of the skin test reaction. Because more patients are 
      sensitized (have IgE antibodies and positive skin test reactions) than have 
      corresponding symptoms, the diagnosis of allergy can be made only by correlating 
      skin testing results with the presence of clinical symptoms.
FAU - Patel, Gayatri
AU  - Patel G
FAU - Saltoun, Carol
AU  - Saltoun C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Allergy Asthma Proc
JT  - Allergy and asthma proceedings
JID - 9603640
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Humans
MH  - Hypersensitivity/*diagnosis
MH  - Immunoglobulin E/analysis
MH  - Intradermal Tests
MH  - Punctures
MH  - Skin Tests/*methods/standards
EDAT- 2019/11/07 06:00
MHDA- 2020/11/06 06:00
CRDT- 2019/11/07 06:00
PHST- 2019/11/07 06:00 [entrez]
PHST- 2019/11/07 06:00 [pubmed]
PHST- 2020/11/06 06:00 [medline]
AID - 10.2500/aap.2019.40.4248 [doi]
PST - ppublish
SO  - Allergy Asthma Proc. 2019 Nov 1;40(6):366-368. doi: 10.2500/aap.2019.40.4248.