PMID- 31692695
OWN - NLM
STAT- MEDLINE
DCOM- 20191121
LR  - 20191121
IS  - 1937-8688 (Electronic)
VI  - 33
DP  - 2019
TI  - [Multiple endocrine neoplasia type 1: about a case].
PG  - 238
LID - 10.11604/pamj.2019.33.238.18053 [doi]
LID - 238
AB  - Multiple endocrine neoplasia type 1 (MEN1) is a rare disease, defined as a tumor 
      developing in at least two endocrine glands including the anterior pituitary 
      gland, the parathyroid glands and the duodenopancreatic endocrine tissue. This 
      disorder, inherited in an autosomal dominant pattern, is caused by mutations in 
      the MEN1 gene encoding the tumor suppressor menin and located on chromosome 
      11q13. However, sporadic cases account for 8-14%. The first endocrine lesion may 
      be solitary in approximately 75% of cases. However, all major alterations can be 
      inaugural. We here report a case of multiple endocrine neoplasia type 1 revealed 
      by aggressive somatoprolactinic pituitary adenoma which didn't respond to 
      conventional treatment. The detection of primary hyperparathyroidism as well as 
      neuroendocrine tumor of the pancreas seven years later make this a very 
      particular case. Therapeutic options are discussed within the multidisciplinary 
      team specialized in endocrine diseases.
CI  - (c) Gladys Anguezomo et al.
FAU - Anguezomo, Gladys
AU  - Anguezomo G
AD  - Service d'Endocrinologie, Diabetologie et Maladies Metaboliques, CHU Mohamed VI 
      Marrakech, Maroc.
AD  - Faculte de Medecine et de Pharmacie de Marrakech, Universite Cadi Ayyad, 
      Marrakech, Maroc.
FAU - El Mghari, Ghizlane
AU  - El Mghari G
AD  - Service d'Endocrinologie, Diabetologie et Maladies Metaboliques, CHU Mohamed VI 
      Marrakech, Maroc.
AD  - Faculte de Medecine et de Pharmacie de Marrakech, Universite Cadi Ayyad, 
      Marrakech, Maroc.
FAU - El Ansari, Nawal
AU  - El Ansari N
AD  - Service d'Endocrinologie, Diabetologie et Maladies Metaboliques, CHU Mohamed VI 
      Marrakech, Maroc.
AD  - Faculte de Medecine et de Pharmacie de Marrakech, Universite Cadi Ayyad, 
      Marrakech, Maroc.
LA  - fre
PT  - Case Reports
TT  - Neoplasie endocrinienne multiple type 1: a propos d'un cas.
DEP - 20190719
PL  - Uganda
TA  - Pan Afr Med J
JT  - The Pan African medical journal
JID - 101517926
RN  - 9002-62-4 (Prolactin)
SB  - IM
MH  - Adenoma/diagnosis/pathology
MH  - Adult
MH  - Humans
MH  - Hyperparathyroidism, Primary/diagnosis
MH  - Male
MH  - Multiple Endocrine Neoplasia Type 1/*diagnosis/pathology
MH  - Neuroendocrine Tumors/*diagnosis/pathology
MH  - Pancreatic Neoplasms/*diagnosis/pathology
MH  - Pituitary Neoplasms/*diagnosis/pathology
MH  - Prolactin/metabolism
PMC - PMC6814935
OTO - NOTNLM
OT  - Neoplasie endocrinienne multiple type1 (NEM1)
OT  - adenome hypophysaire
OT  - hyperparathyroidie
OT  - pNET
COIS- Les auteurs ne declarent aucun conflit d'interets.
EDAT- 2019/11/07 06:00
MHDA- 2019/11/22 06:00
PMCR- 2019/07/19
CRDT- 2019/11/07 06:00
PHST- 2018/12/30 00:00 [received]
PHST- 2019/02/22 00:00 [accepted]
PHST- 2019/11/07 06:00 [entrez]
PHST- 2019/11/07 06:00 [pubmed]
PHST- 2019/11/22 06:00 [medline]
PHST- 2019/07/19 00:00 [pmc-release]
AID - PAMJ-33-238 [pii]
AID - 10.11604/pamj.2019.33.238.18053 [doi]
PST - epublish
SO  - Pan Afr Med J. 2019 Jul 19;33:238. doi: 10.11604/pamj.2019.33.238.18053. 
      eCollection 2019.