PMID- 31694082
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200108
IS  - 2233-6079 (Print)
IS  - 2233-6087 (Electronic)
IS  - 2233-6079 (Linking)
VI  - 43
IP  - 5
DP  - 2019 Oct
TI  - Severity of Nonalcoholic Fatty Liver Disease in Type 2 Diabetes Mellitus: 
      Relationship between Nongenetic Factors and PNPLA3/HSD17B13 Polymorphisms.
PG  - 700-710
LID - 10.4093/dmj.2018.0201 [doi]
AB  - BACKGROUND: The prevalence of nonalcoholic fatty liver disease (NAFLD) in 
      patients with type 2 diabetes mellitus (T2DM) is high, though its severity is 
      often underestimated. Our aim is to provide an estimate of the prevalence of 
      severe NAFLD in T2DM and identify its major predictors. METHODS: T2DM patients 
      (n=328) not previously known to have NAFLD underwent clinical assessment, 
      transient elastography with measure of liver stiffness (LS) and controlled 
      attenuation parameter (CAP), and genotyping for patatin like phospholipase domain 
      containing 3 (PNPLA3) and 17beta-hydroxysteroid-dehydrogenase type 13 (HSD17B13). 
      RESULTS: Median LS was 6.1 kPa (4.9 to 8.6). More than one-fourth patients had 
      advanced liver disease, defined as LS >/=7.9 kPa (n=94/238, 29%), and had a higher 
      body mass index (BMI) than those with a LS <7.9 kPa. Carriage of the G allele in 
      the PNPLA3 gene was associated with higher LS, being 5.9 kPa (4.7 to 7.7) in C/C 
      homozygotes, 6.1 kPa (5.2 to 8.7) in C/G heterozygotes, and 6.8 kPa (5.8 to 9.2) 
      in G/G homozygotes (P=0.01). This trend was absent in patients with >/=1 mutated 
      HSD17B13 allele. In a multiple linear regression model, BMI and PNPLA3 genotype 
      predicted LS, while age, gender, disease duration, and glycosylated hemoglobin 
      did not fit into the model. None of these variables was confirmed to be 
      predictive among carriers of at least one HSD17B13 mutated allele. There was no 
      association between CAP and polymorphisms of PNPLA3 or HSD17B13. CONCLUSION: 
      Advanced NAFLD is common among T2DM patients. LS is predicted by both BMI and 
      PNPLA3 polymorphism, the effect of the latter being modulated by mutated 
      HSD17B13.
CI  - Copyright (c) 2019 Korean Diabetes Association.
FAU - Bellan, Mattia
AU  - Bellan M
AUID- ORCID: 0000-0003-1488-8736
AD  - Department of Translational Medicine, University of Eastern Piedmont, Novara, 
      Italy.
AD  - Division of Internal Medicine, Sant'Andrea Hospital, Vercelli, Italy.
AD  - Interdisciplinary Research Center of Autoimmune Diseases (IRCAD), Novara, Italy. 
      bellanmattia@yahoo.it.
FAU - Colletta, Cosimo
AU  - Colletta C
AUID- ORCID: 0000-0002-5910-3253
AD  - COQ, Madonna del Popolo, Omegna, Italy.
FAU - Barbaglia, Matteo Nazzareno
AU  - Barbaglia MN
AD  - Department of Translational Medicine, University of Eastern Piedmont, Novara, 
      Italy.
FAU - Salmi, Livia
AU  - Salmi L
AD  - Department of Translational Medicine, University of Eastern Piedmont, Novara, 
      Italy.
FAU - Clerici, Roberto
AU  - Clerici R
AD  - Department of Translational Medicine, University of Eastern Piedmont, Novara, 
      Italy.
FAU - Mallela, Venkata Ramana
AU  - Mallela VR
AD  - Department of Translational Medicine, University of Eastern Piedmont, Novara, 
      Italy.
FAU - Castello, Luigi Mario
AU  - Castello LM
AD  - Department of Translational Medicine, University of Eastern Piedmont, Novara, 
      Italy.
AD  - Emergency Medicine Department, Maggiore della Carita Hospital, Novara, Italy.
FAU - Saglietti, Giuseppe
AU  - Saglietti G
AD  - Diabetes Clinic, ASL VCO, Verbania, Italy.
FAU - Carnevale Schianca, Gian Piero
AU  - Carnevale Schianca GP
AD  - Division of Internal Medicine, AOU Maggiore della Carita Hospital, Novara, Italy.
FAU - Minisini, Rosalba
AU  - Minisini R
AD  - Department of Translational Medicine, University of Eastern Piedmont, Novara, 
      Italy.
FAU - Pirisi, Mario
AU  - Pirisi M
AD  - Department of Translational Medicine, University of Eastern Piedmont, Novara, 
      Italy.
AD  - Interdisciplinary Research Center of Autoimmune Diseases (IRCAD), Novara, Italy.
AD  - Division of Internal Medicine, AOU Maggiore della Carita Hospital, Novara, Italy.
LA  - eng
PT  - Journal Article
PL  - Korea (South)
TA  - Diabetes Metab J
JT  - Diabetes & metabolism journal
JID - 101556588
PMC - PMC6834828
OTO - NOTNLM
OT  - Adiponutrin
OT  - Body mass index
OT  - Diabetes mellitus, type 2
OT  - Fibrosis
OT  - Non-alcoholic fatty liver disease
COIS- No potential conflict of interest relevant to this article was reported.
EDAT- 2019/11/07 06:00
MHDA- 2019/11/07 06:01
PMCR- 2019/10/01
CRDT- 2019/11/07 06:00
PHST- 2018/10/04 00:00 [received]
PHST- 2019/02/04 00:00 [accepted]
PHST- 2019/11/07 06:00 [entrez]
PHST- 2019/11/07 06:00 [pubmed]
PHST- 2019/11/07 06:01 [medline]
PHST- 2019/10/01 00:00 [pmc-release]
AID - 43.700 [pii]
AID - 10.4093/dmj.2018.0201 [doi]
PST - ppublish
SO  - Diabetes Metab J. 2019 Oct;43(5):700-710. doi: 10.4093/dmj.2018.0201.