PMID- 31694117
OWN - NLM
STAT- MEDLINE
DCOM- 20191115
LR  - 20200108
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 99
IP  - 41
DP  - 2019 Nov 5
TI  - [Clinical significance of anti-interferon -alpha2 and anti-interferon -omega antibody in 
      myasthenia gravis].
PG  - 3227-3231
LID - 10.3760/cma.j.issn.0376-2491.2019.41.006 [doi]
AB  - Objective: To measure the levels of anti-interferon (IFN) -alpha2 antibody 
      (IFN-alpha2-Ab) and anti-IFN-omega antibody(IFN-omega-Ab) and investigate their potential 
      roles in patients with myasthenia gravis (MG). Methods: 
      Radioimmunoprecipitationassay (RIPA) based on (125)I-labelled IFN-alpha2, -omega, 
      acetylcholine receptor (AChR) and muscle-specific kinase (MuSK) were used to 
      detect anti-IFN-alpha2-Ab, anti-IFN-omega-Ab, anti-AChR-Ab and anti-MuSK-Ab respectively 
      in MG patients from Tianjin Medical University General Hospital, during the year 
      of 2013. Relationship between IFN-alpha2-Ab and clinical characteristics in patients 
      with MG were analyzed. Results: With the RIPA, anti-IFN-alpha2-Ab was positive in 11 
      (22%) patients with MG, among whom, 8 were thymoma associated MG (TAMG) and 3 
      were late onset MG (LOMG). The double positive one was among the LOMG who was a 
      76-year-old ocular MG patient. Serum anti-IFN-alpha2-Ab levels in different subgroups 
      of MG had no significant difference (P>0.05). MG patients with anti-IFN-alpha2-Ab 
      complicated with less other autoimmune disease. Serum anti-IFN-alpha2-Ab levels 
      negatively correlated with QMG score in TAMG. Conclusions: MG patients with 
      anti-IFN-alpha2-Ab complicate with less other autoimmune disease. The higher serum 
      IFN-alpha2-Ab levels in TAMG, the slighter symptoms present.
FAU - Qi, Y
AU  - Qi Y
AD  - Department of Neurology, Tianjin Medical University General Hospital, Tianjin 
      300052, China.
FAU - Zhang, L J
AU  - Zhang LJ
FAU - Zhang, Q X
AU  - Zhang QX
FAU - Wang, J
AU  - Wang J
FAU - Yang, L
AU  - Yang L
LA  - chi
GR  - 81771363/National Natural Science Foundation of China (General Program)/
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
RN  - 0 (Antiviral Agents)
RN  - 0 (Autoantibodies)
SB  - IM
MH  - Aged
MH  - *Antiviral Agents
MH  - Autoantibodies
MH  - Humans
MH  - *Myasthenia Gravis
MH  - *Thymoma
MH  - *Thymus Neoplasms
OTO - NOTNLM
OT  - Autoantibody
OT  - Interferon-alpha2
OT  - Myasthenia gravis
OT  - Radioimmunoprecipitation assay
EDAT- 2019/11/07 06:00
MHDA- 2019/11/16 06:00
CRDT- 2019/11/07 06:00
PHST- 2019/11/07 06:00 [entrez]
PHST- 2019/11/07 06:00 [pubmed]
PHST- 2019/11/16 06:00 [medline]
AID - 10.3760/cma.j.issn.0376-2491.2019.41.006 [doi]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2019 Nov 5;99(41):3227-3231. doi: 
      10.3760/cma.j.issn.0376-2491.2019.41.006.