PMID- 31694209
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 8
IP  - 11
DP  - 2019 Nov 5
TI  - Risk of Cancers in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: 
      Results from the Korea National Health Insurance Claims Database 2010-2018.
LID - 10.3390/jcm8111871 [doi]
LID - 1871
AB  - The association between antineutrophil cytoplasmic antibody-associated vasculitis 
      (AAV) and cancer remains poorly understood. In this study, we searched the Korea 
      National Health Insurance Claims Database to obtain data for 2097 AAV patients, 
      and evaluated the risk of cancers in AAV. The standardized incidence ratios 
      (SIRs) of overall and site-specific cancers were estimated in patients with AAV 
      compared to the general population. The overall risk of cancer was significantly 
      higher in patients with AAV (SIR 1.90); this remained true in both males (SIR 
      1.74) and females (SIR 2.06). For site-specific cancers, the risks of lung (SIR 
      2.23) and hematological (SIR 11.39) cancers were higher in AAV patients. For 
      males, the risks of gallbladder and hematological cancers were increased, while 
      the risks of bladder and hematological cancers were increased in females. Among 
      AAV subtypes, patients with granulomatosis with polyangiitis had the highest risk 
      of cancers, and cyclophosphamide, azathioprine/mizoribine, and methotrexate 
      ever-users had increased risk of overall cancer. The risks of overall and 
      hematological cancers were elevated in AAV patients younger than 60 years old. 
      Patients with AAV have increased risks of overall, lung, and hematological 
      cancers. Distinct patterns of cancer incidence are present according to age, sex, 
      AAV subtypes, and immunosuppressant usage.
FAU - Ahn, Sung Soo
AU  - Ahn SS
AD  - Division of Rheumatology, Department of Internal Medicine, Yonsei University 
      College of Medicine, Seoul 03722, Korea.
FAU - Han, Minkyung
AU  - Han M
AUID- ORCID: 0000-0002-5011-5557
AD  - Biostatistics Collaboration Unit, Department of Biomedical Systems Informatics, 
      Yonsei University College of Medicine, Seoul 03722, Korea.
FAU - Yoo, Juyoung
AU  - Yoo J
AD  - Division of Rheumatology, Department of Internal Medicine, Yonsei University 
      College of Medicine, Seoul 03722, Korea.
FAU - Jung, Seung Min
AU  - Jung SM
AD  - Division of Rheumatology, Department of Internal Medicine, Yonsei University 
      College of Medicine, Seoul 03722, Korea.
FAU - Song, Jason Jungsik
AU  - Song JJ
AUID- ORCID: 0000-0003-0662-7704
AD  - Division of Rheumatology, Department of Internal Medicine, Yonsei University 
      College of Medicine, Seoul 03722, Korea.
AD  - Institute for Immunology and Immunological Diseases, Yonsei University College of 
      Medicine, Seoul 03722, Korea.
FAU - Park, Yong-Beom
AU  - Park YB
AD  - Division of Rheumatology, Department of Internal Medicine, Yonsei University 
      College of Medicine, Seoul 03722, Korea.
AD  - Institute for Immunology and Immunological Diseases, Yonsei University College of 
      Medicine, Seoul 03722, Korea.
FAU - Jung, Inkyung
AU  - Jung I
AUID- ORCID: 0000-0003-3780-3213
AD  - Division of Biostatistics, Department of Biomedical Systems Informatics, Yonsei 
      University College of Medicine, Seoul 03722, Korea.
FAU - Lee, Sang-Won
AU  - Lee SW
AD  - Division of Rheumatology, Department of Internal Medicine, Yonsei University 
      College of Medicine, Seoul 03722, Korea.
AD  - Institute for Immunology and Immunological Diseases, Yonsei University College of 
      Medicine, Seoul 03722, Korea.
LA  - eng
GR  - 2017R1D1A1B03029050/National Research Foundation of Korea/
GR  - HI14C1324/Korea Health Industry Development Institute/Republic of Korea
PT  - Journal Article
DEP - 20191105
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC6912195
OTO - NOTNLM
OT  - antineutrophil cytoplasmic antibody
OT  - cancer
OT  - incidence
OT  - risk
OT  - vasculitis
COIS- The authors declare no conflict of interest.
EDAT- 2019/11/07 06:00
MHDA- 2019/11/07 06:01
PMCR- 2019/11/05
CRDT- 2019/11/08 06:00
PHST- 2019/09/16 00:00 [received]
PHST- 2019/10/26 00:00 [revised]
PHST- 2019/10/30 00:00 [accepted]
PHST- 2019/11/08 06:00 [entrez]
PHST- 2019/11/07 06:00 [pubmed]
PHST- 2019/11/07 06:01 [medline]
PHST- 2019/11/05 00:00 [pmc-release]
AID - jcm8111871 [pii]
AID - jcm-08-01871 [pii]
AID - 10.3390/jcm8111871 [doi]
PST - epublish
SO  - J Clin Med. 2019 Nov 5;8(11):1871. doi: 10.3390/jcm8111871.