PMID- 31695587
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220411
IS  - 1650-3414 (Electronic)
IS  - 1650-3414 (Linking)
VI  - 30
IP  - 3
DP  - 2019 Oct
TI  - Prevalence of Liver Function Test Abnormality and Associated Factors in Type 2 
      Diabetes Mellitus: A Comparative Cross-Sectional Study.
PG  - 303-316
AB  - BACKGROUND: Determining liver biomarkers can help to screen and facilitate early 
      management of potential liver diseases. However, such studies are scarce in the 
      present study area. Therefore, our study planned to assess the prevalence of 
      liver function test abnormality and associated factors among Type 2 Diabetes 
      Mellitus (T2DM) patients. METHODS: A comparative cross-sectional study was 
      conducted at the University of Gondar Comprehensive Specialized Hospital from 
      January 1, 2018 to May 20, 2018 among 159 T2DM patients and 159 nondiabetic 
      controls. Clinical, lifestyle, anthropometric data and 5 ml of blood were 
      collected from all study subjects. Liver function tests (LFTs), lipid profiles 
      and fasting blood sugar were determined. Systematic random sampling technique was 
      used to select the study subjects. Binary logistic regression and bivariate 
      correlation was used to assess association of factors with outcomes and p value 
      of </=0.05 was considered as significant. RESULTS: Overall, 53 (33.3%) of T2DM had 
      one or more liver test abnormality above the upper limit of the normal (ULN) 
      reference range. Alanine aminotransferase was the most frequently raised liver 
      enzyme in T2DM (n=37, 23.3%). The mean value of LFTs was significantly different 
      between T2DM and the control group. Alcohol drink, sex and age were found to be a 
      significant factor for impairment of LFTs. CONCLUSION: The prevalence of abnormal 
      LFTs was higher in T2DM patients than nondiabetic control group. Hence, we 
      recommended the utilization of LFTs to monitor liver conditions in T2DM patients.
CI  - Copyright (c) 2019 International Federation of Clinical Chemistry and Laboratory 
      Medicine (IFCC). All rights reserved.
FAU - Teshome, Getnet
AU  - Teshome G
AD  - Comprehensive Specialized Hospital, College of Medicine and Health Sciences, 
      University of Gondar, Ethiopia.
FAU - Ambachew, Sintayehu
AU  - Ambachew S
AD  - College of Medicine and Health Sciences, School of Biomedical and Laboratory 
      Sciences, Department of Clinical Chemistry, University of Gondar, Ethiopia.
FAU - Fasil, Alebachew
AU  - Fasil A
AD  - College of Medicine and Health Sciences, School of Biomedical and Laboratory 
      Sciences, Department of Clinical Chemistry, University of Gondar, Ethiopia.
FAU - Abebe, Molla
AU  - Abebe M
AD  - College of Medicine and Health Sciences, School of Biomedical and Laboratory 
      Sciences, Department of Clinical Chemistry, University of Gondar, Ethiopia.
LA  - eng
PT  - Journal Article
DEP - 20191011
PL  - Italy
TA  - EJIFCC
JT  - EJIFCC
JID - 101092742
PMC - PMC6803769
OTO - NOTNLM
OT  - diabetes mellitus
OT  - liver disease
OT  - liver function tests
COIS- Competing interest All authors declared that there is no competing interest 
      between all authors.
EDAT- 2019/11/07 06:00
MHDA- 2019/11/07 06:01
PMCR- 2019/10/11
CRDT- 2019/11/08 06:00
PHST- 2019/11/08 06:00 [entrez]
PHST- 2019/11/07 06:00 [pubmed]
PHST- 2019/11/07 06:01 [medline]
PHST- 2019/10/11 00:00 [pmc-release]
AID - ejifcc-30-303 [pii]
PST - epublish
SO  - EJIFCC. 2019 Oct 11;30(3):303-316. eCollection 2019 Oct.