PMID- 31696563
OWN - NLM
STAT- MEDLINE
DCOM- 20201016
LR  - 20220413
IS  - 1365-3164 (Electronic)
IS  - 0959-4493 (Linking)
VI  - 31
IP  - 2
DP  - 2020 Apr
TI  - Antibody levels to Malassezia pachydermatis and Staphylococcus pseudintermedius 
      in atopic dogs and their relationship with lesion scores.
PG  - 111-115
LID - 10.1111/vde.12802 [doi]
AB  - BACKGROUND: Elevated immunoglobulin E (IgE) levels to Malassezia or 
      Staphylococcus species in human atopic dermatitis are related to the skin 
      severity index; a similar association has not been reported in atopic dogs. 
      OBJECTIVES: To investigate serum levels of allergen-specific IgE, total specific 
      IgG and IgG subclasses (IgG1 and IgG2) for M. pachydermatis and 
      S. pseudintermedius, and to correlate them with the severity of dermatitis in 
      dogs. ANIMALS: Serum samples were collected from dogs categorized by age and 
      disease status. Groups 1 and 2: <3-year-old healthy (n = 9) and atopic dogs 
      (n = 9), respectively; and groups 3 and 4: >/=3-year-old healthy (n = 11) and 
      atopic dogs (n = 14), respectively. METHODS AND MATERIALS: Antibody levels were 
      measured by ELISA. The Canine Atopic Dermatitis Lesion Index (CADLI) was analyzed 
      in relation to antibody levels. RESULTS: Specific IgE and total IgG against 
      M. pachydermatis and S. pseudintermedius were significantly increased in atopic 
      dogs of all ages. Although differences between atopic and healthy dogs, with 
      regard to specific IgG1 and IgG2 levels to each microbe, varied in significance 
      within age groups. No significant relationships were found between the CADLI and 
      any specific immunoglobulin levels for both microbe types. CONCLUSIONS AND 
      CLINICAL IMPORTANCE: In dog skin, microbes may act as allergens triggering 
      inflammatory responses via IgE- and IgG-dependent pathway(s). The affinity of the 
      IgG subclass produced may vary according to antigen type. Specific IgE levels may 
      be related to clinical disease in dogs and not to skin lesion severity.
CI  - (c) 2019 ESVD and ACVD.
FAU - Khantavee, Nathrada
AU  - Khantavee N
AD  - Department of Veterinary Microbiology, Faculty of Veterinary Science, 
      Chulalongkorn University, 39 Henri-Dunant Road, Pathumwan, Bangkok, 10330, 
      Thailand.
FAU - Chanthick, Chanettee
AU  - Chanthick C
AD  - Dermatology Unit, Veterinary Teaching Hospital, Faculty of Veterinary Medicine, 
      Kasetsart University, 50 Paholyothin Road, Ladyao, Chatuchuk, Bangkok, 10900, 
      Thailand.
FAU - Sookrung, Nitat
AU  - Sookrung N
AD  - Department of Research and Development, Faculty of Medicine Siriraj Hospital, 
      Mahidol University, 2 Wanglang Road, Bangkok-noi, Bangkok, 10700, Thailand.
FAU - Prapasarakul, Nuvee
AU  - Prapasarakul N
AUID- ORCID: 0000-0001-6409-4622
AD  - Department of Veterinary Microbiology, Faculty of Veterinary Science, 
      Chulalongkorn University, 39 Henri-Dunant Road, Pathumwan, Bangkok, 10330, 
      Thailand.
AD  - Diagnosis and Monitoring of Animal Pathogens Research Unit, Chulalongkorn 
      University, 39 Henri-Dunant Road, Pathumwan, Bangkok, 10330, Thailand.
LA  - eng
GR  - RSA 5980056/Thailand Research Fund/
PT  - Journal Article
DEP - 20191106
PL  - England
TA  - Vet Dermatol
JT  - Veterinary dermatology
JID - 9426187
RN  - 0 (Antibodies, Bacterial)
RN  - 0 (Antibodies, Fungal)
RN  - 0 (Immunoglobulin G)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - Staphylococcus pseudintermedius
SB  - IM
EIN - Vet Dermatol. 2020 Oct;31(5):427. PMID: 33463818
MH  - Animals
MH  - Antibodies, Bacterial/*blood
MH  - Antibodies, Fungal/*blood
MH  - Dermatitis, Atopic/immunology/microbiology/*veterinary
MH  - Dermatomycoses/immunology/pathology/*veterinary
MH  - Dog Diseases/*immunology/microbiology/pathology
MH  - Dogs
MH  - Immunoglobulin E/blood
MH  - Immunoglobulin G/blood
MH  - Malassezia
MH  - Skin/microbiology/pathology
MH  - Skin Tests
MH  - Staphylococcal Skin Infections/immunology/pathology/*veterinary
MH  - Staphylococcus
EDAT- 2019/11/07 06:00
MHDA- 2020/10/21 06:00
CRDT- 2019/11/08 06:00
PHST- 2019/08/21 00:00 [accepted]
PHST- 2019/11/07 06:00 [pubmed]
PHST- 2020/10/21 06:00 [medline]
PHST- 2019/11/08 06:00 [entrez]
AID - 10.1111/vde.12802 [doi]
PST - ppublish
SO  - Vet Dermatol. 2020 Apr;31(2):111-115. doi: 10.1111/vde.12802. Epub 2019 Nov 6.