PMID- 31696836
OWN - NLM
STAT- MEDLINE
DCOM- 20210621
LR  - 20221207
IS  - 1745-7262 (Electronic)
IS  - 1008-682X (Print)
IS  - 1008-682X (Linking)
VI  - 22
IP  - 4
DP  - 2020 Jul-Aug
TI  - Efficacy and safety of low-intensity shockwave therapy plus tadalafil 5 mg once 
      daily in men with type 2 diabetes mellitus and erectile dysfunction: a 
      matched-pair comparison study.
PG  - 379-382
LID - 10.4103/aja.aja_121_19 [doi]
AB  - Low-intensity extracorporeal shockwave therapy (LiESWT) represents a promising 
      treatment for patients with erectile dysfunction (ED). We investigated the 
      efficacy of LiESWT combined with tadalafil 5 mg once daily in men with type 2 
      diabetes mellitus (T2DM) and ED and compared LiESWT protocols administering 
      different number of shockwaves. We performed a retrospective matched-pair 
      comparison using data from a prospectively maintained database. Seventy-eight 
      patients who received tadalafil 5 mg once daily for 12 weeks + LiESWT performed 
      with an electrohydraulic source for 3 weeks (Group A) were matched 1:1 to 
      patients who received tadalafil 5 mg once daily alone for 12 weeks (Group B). A 
      subgroup analysis was performed according to the number of shockwaves delivered 
      during each session (1500, 1800, and 2400 in subgroup A1, A2, and A3, 
      respectively). The mean International Index of Erectile Function-5 (IIEF-5) score 
      variations with respect to baseline recorded at 4, 12, and 24 weeks after the end 
      of the treatment were investigated as treatment outcomes. The mean IIEF-5 scores 
      significantly improved in all groups and subgroups at 4-week follow-up without 
      intergroup differences. At 12- and 24-week follow-up, the mean IIEF-5 improvement 
      was significantly higher among patients in the A3 subgroup (+5.0 +/- 2.1 [P < 
      0.001] and +4.7 +/- 2.3 [P < 0.001], respectively). The combined approach with 
      tadalafil 5 mg once daily and LiESWT with a protocol involving 2400 shockwaves 
      provides significant advantages in terms of IIEF-5 improvement and durability 
      compared to tadalafil 5 mg once daily alone in patients with T2DM and ED.
FAU - Verze, Paolo
AU  - Verze P
AD  - Department of Neurosciences, Reproductive Sciences and Odontostomatology, 
      University of Naples "Federico II," Naples 80131, Italy.
FAU - Capece, Marco
AU  - Capece M
AD  - Department of Neurosciences, Reproductive Sciences and Odontostomatology, 
      University of Naples "Federico II," Naples 80131, Italy.
FAU - Creta, Massimiliano
AU  - Creta M
AD  - Department of Neurosciences, Reproductive Sciences and Odontostomatology, 
      University of Naples "Federico II," Naples 80131, Italy.
FAU - La Rocca, Roberto
AU  - La Rocca R
AD  - Department of Neurosciences, Reproductive Sciences and Odontostomatology, 
      University of Naples "Federico II," Naples 80131, Italy.
FAU - Persico, Francesco
AU  - Persico F
AD  - Department of Neurosciences, Reproductive Sciences and Odontostomatology, 
      University of Naples "Federico II," Naples 80131, Italy.
FAU - Spirito, Lorenzo
AU  - Spirito L
AD  - Department of Neurosciences, Reproductive Sciences and Odontostomatology, 
      University of Naples "Federico II," Naples 80131, Italy.
FAU - Cardi, Antonio
AU  - Cardi A
AD  - Department of Urology, San Giovanni Addolorata Hospital, Rome 00184, Italy.
FAU - Mirone, Vincenzo
AU  - Mirone V
AD  - Department of Neurosciences, Reproductive Sciences and Odontostomatology, 
      University of Naples "Federico II," Naples 80131, Italy.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - China
TA  - Asian J Androl
JT  - Asian journal of andrology
JID - 100942132
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Phosphodiesterase 5 Inhibitors)
RN  - 0 (hemoglobin A1c protein, human)
RN  - 742SXX0ICT (Tadalafil)
SB  - IM
MH  - Aged
MH  - Combined Modality Therapy
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Erectile Dysfunction/complications/physiopathology/*therapy
MH  - Glycated Hemoglobin/metabolism
MH  - Humans
MH  - Male
MH  - Matched-Pair Analysis
MH  - Middle Aged
MH  - Phosphodiesterase 5 Inhibitors/*therapeutic use
MH  - Retrospective Studies
MH  - Tadalafil/*therapeutic use
MH  - Treatment Outcome
MH  - Ultrasonic Therapy/*methods
MH  - Ultrasonic Waves
PMC - PMC7406094
OTO - NOTNLM
OT  - diabetes mellitus
OT  - erectile dysfunction
OT  - low-intensity shockwave therapy
OT  - tadalafil
COIS- None
EDAT- 2019/11/08 06:00
MHDA- 2021/06/22 06:00
PMCR- 2019/11/01
CRDT- 2019/11/08 06:00
PHST- 2019/11/08 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2019/11/08 06:00 [entrez]
PHST- 2019/11/01 00:00 [pmc-release]
AID - 270157 [pii]
AID - AJA-22-379 [pii]
AID - 10.4103/aja.aja_121_19 [doi]
PST - ppublish
SO  - Asian J Androl. 2020 Jul-Aug;22(4):379-382. doi: 10.4103/aja.aja_121_19.