PMID- 31697449
OWN - NLM
STAT- MEDLINE
DCOM- 20210528
LR  - 20210528
IS  - 2472-1727 (Electronic)
VI  - 112
IP  - 1
DP  - 2020 Jan 1
TI  - A pilot study on the effect of early provision of dietary docosahexaenoic acid on 
      testis development, functions, and sperm quality in rats exposed to prenatal 
      ethanol.
PG  - 93-104
LID - 10.1002/bdr2.1614 [doi]
AB  - BACKGROUND: Prenatal ethanol (EtOH) exposure is associated with adverse effect on 
      the male reproductive function. Dietary docosahexaenoic acid (DHA) is known to 
      improve testis function and sperm parameters, thereby male fertility. This study 
      piloted whether dietary DHA influences testis development and function in rats 
      exposed to prenatal EtOH. METHODS: Pregnant female Sprague-Dawley rats (n = 30) 
      received either EtOH (3 g/kg, twice a day, n = 14) or dextrose (n = 16) 
      throughout pregnancy. Moreover, they were fed either diet supplemented with 
      (Cont + DHA, n = 8, EtOH + DHA, n = 6) or without DHA (1.4% w/w of total fatty 
      acids) (Cont, EtOH, n = 8 each), with pups being continued on their mothers' diet 
      after weaning. Tissues were collected at gestational day (GD) 20, postnatal day 
      (PD) 4, 21, 49 and 90 for analyzing testicular developmental markers and sperm 
      parameters, and plasma for testosterone. RESULTS: Dietary DHA increased serum 
      testosterone at GD20 (p < .05) and sperm normal morphology at PD90 (p < .0001) 
      compared to the group without DHA supplementation. Dietary DHA also increased the 
      height of germinal epithelium at peripuberty, PD49 (p < .03). The EtOH exposure 
      induced a marked decline in the testicular gene expression of StAR at PD49 
      (p < .02) than those of non-EtOH treated group. CONCLUSIONS: These findings 
      indicate that dietary DHA may positively contribute to male fertility by 
      impacting sperm normal morphology likely by increasing fetal testosterone level. 
      Prenatal EtOH exposure did not adversely affect the overall testis developmental 
      markers during development and sperm parameters in adulthood.
CI  - (c) 2019 Wiley Periodicals, Inc.
FAU - Kapourchali, Fatemeh R
AU  - Kapourchali FR
AUID- ORCID: 0000-0003-4173-8952
AD  - Department of Inflammation and Immunity, Lerner Research Institute, Cleveland 
      Clinic, Cleveland, Ohio.
AD  - Department of Food and Human Nutritional Sciences, University of Manitoba, 
      Winnipeg, Manitoba, Canada.
AD  - Division of Neurodegenerative Disorders, St. Boniface Hospital Albrechtsen 
      Research Centre, Winnipeg, Manitoba, Canada.
AD  - Canadian Centre for Agri-Food Research in Health and Medicine, St. Boniface 
      Hospital Albrechtsen Research Centre, Winnipeg, Manitoba, Canada.
FAU - Louis, Xavier L
AU  - Louis XL
AD  - Department of Food and Human Nutritional Sciences, University of Manitoba, 
      Winnipeg, Manitoba, Canada.
AD  - Division of Neurodegenerative Disorders, St. Boniface Hospital Albrechtsen 
      Research Centre, Winnipeg, Manitoba, Canada.
AD  - Canadian Centre for Agri-Food Research in Health and Medicine, St. Boniface 
      Hospital Albrechtsen Research Centre, Winnipeg, Manitoba, Canada.
FAU - Eskin, Michael N A
AU  - Eskin MNA
AD  - Department of Inflammation and Immunity, Lerner Research Institute, Cleveland 
      Clinic, Cleveland, Ohio.
FAU - Suh, Miyoung
AU  - Suh M
AD  - Department of Food and Human Nutritional Sciences, University of Manitoba, 
      Winnipeg, Manitoba, Canada.
AD  - Division of Neurodegenerative Disorders, St. Boniface Hospital Albrechtsen 
      Research Centre, Winnipeg, Manitoba, Canada.
AD  - Canadian Centre for Agri-Food Research in Health and Medicine, St. Boniface 
      Hospital Albrechtsen Research Centre, Winnipeg, Manitoba, Canada.
LA  - eng
GR  - #317852/Research Manitoba/International
GR  - Canada-Israel International Fetal Alcohol Consortium (CIIFAC)/International
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20191107
PL  - United States
TA  - Birth Defects Res
JT  - Birth defects research
JID - 101701004
RN  - 0 (Fatty Acids)
RN  - 25167-62-8 (Docosahexaenoic Acids)
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - Animals
MH  - Diet
MH  - Dietary Supplements
MH  - Docosahexaenoic Acids/metabolism/*pharmacology
MH  - Ethanol/*adverse effects
MH  - Fatty Acids
MH  - Female
MH  - Male
MH  - Pilot Projects
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Spermatozoa/drug effects/metabolism
MH  - Testis/*drug effects/embryology/metabolism
OTO - NOTNLM
OT  - dietary docosahexaenoic acid
OT  - polyunsaturated fatty acids
OT  - prenatal ethanol exposure
OT  - reproductive functions
OT  - sperm parameters
OT  - testosterone
EDAT- 2019/11/08 06:00
MHDA- 2021/05/29 06:00
CRDT- 2019/11/08 06:00
PHST- 2019/02/16 00:00 [received]
PHST- 2019/08/27 00:00 [revised]
PHST- 2019/10/17 00:00 [accepted]
PHST- 2019/11/08 06:00 [pubmed]
PHST- 2021/05/29 06:00 [medline]
PHST- 2019/11/08 06:00 [entrez]
AID - 10.1002/bdr2.1614 [doi]
PST - ppublish
SO  - Birth Defects Res. 2020 Jan 1;112(1):93-104. doi: 10.1002/bdr2.1614. Epub 2019 
      Nov 7.