PMID- 31697753
OWN - NLM
STAT- MEDLINE
DCOM- 20200323
LR  - 20200323
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 14
IP  - 11
DP  - 2019
TI  - Proton pump inhibitor use increases the risk of peritonitis in peritoneal 
      dialysis patients.
PG  - e0224859
LID - 10.1371/journal.pone.0224859 [doi]
LID - e0224859
AB  - Peritonitis is a major and the most significant complication of peritoneal 
      dialysis (PD). Although some predictors of peritonitis in PD patients are known, 
      the association between proton pump inhibitor (PPI) use and peritonitis has not 
      been characterized. Here, we examined whether PPI use is a risk factor for the 
      development of peritonitis, based on a single-center retrospective analysis of 
      230 consecutive Japanese PD patients at Narita Memorial Hospital. We assessed the 
      association between PPI use and subsequent first episode of peritonitis using 
      multivariate Cox proportional hazards models, following adjustment for clinically 
      relevant factors. The median follow-up period was 36 months (interquartile range, 
      19-57 months). In total, 86 patients (37.4%) developed peritonitis. Analysis with 
      multivariate Cox proportional hazards models revealed the following significant 
      predictors of peritonitis: PPI use (adjusted hazard ratio [HR] = 1.72, 95% 
      confidence interval [CI]: 1.11-2.66; P = 0.016) and low serum albumin level (per 
      g/dl adjusted HR = 0.59, 95% CI: 0.39-0.90; P = 0.014). Thus, PPI use was 
      independently associated with PD-related peritonitis. The results suggest that 
      nephrology physicians should exercise caution when prescribing PPIs for PD 
      patients.
FAU - Maeda, Sayaka
AU  - Maeda S
AD  - Department of Nephrology, Narita Memorial Hospital, Toyohashi, Japan.
FAU - Yamaguchi, Makoto
AU  - Yamaguchi M
AD  - Department of Nephrology and Rheumatology, Aichi Medical University, Nagakute, 
      Japan.
FAU - Maeda, Kunihiro
AU  - Maeda K
AD  - Department of Nephrology, Narita Memorial Hospital, Toyohashi, Japan.
FAU - Kobayashi, Naoto
AU  - Kobayashi N
AD  - Department of Nephrology, Narita Memorial Hospital, Toyohashi, Japan.
FAU - Izumi, Naoki
AU  - Izumi N
AD  - Department of Nephrology, Narita Memorial Hospital, Toyohashi, Japan.
FAU - Nagai, Masaaki
AU  - Nagai M
AD  - Department of Nephrology, Narita Memorial Hospital, Toyohashi, Japan.
FAU - Obayashi, Takaaki
AU  - Obayashi T
AD  - Department of Nephrology, Narita Memorial Hospital, Toyohashi, Japan.
FAU - Ohashi, Wataru
AU  - Ohashi W
AD  - Division of Biostatistics, Clinical Research Center, Aichi Medical University, 
      Nagakute, Japan.
FAU - Katsuno, Takayuki
AU  - Katsuno T
AD  - Department of Nephrology and Rheumatology, Aichi Medical University, Nagakute, 
      Japan.
FAU - Nobata, Hironobu
AU  - Nobata H
AD  - Department of Nephrology and Rheumatology, Aichi Medical University, Nagakute, 
      Japan.
FAU - Ito, Yasuhiko
AU  - Ito Y
AUID- ORCID: 0000-0002-9676-6961
AD  - Department of Nephrology and Rheumatology, Aichi Medical University, Nagakute, 
      Japan.
LA  - eng
PT  - Journal Article
DEP - 20191107
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Aged
MH  - Female
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Peritoneal Dialysis/*adverse effects
MH  - Peritonitis/chemically induced/*epidemiology
MH  - Proportional Hazards Models
MH  - Proton Pump Inhibitors/*adverse effects
MH  - Retrospective Studies
PMC - PMC6837385
COIS- The authors have declared that no competing interests exist.
EDAT- 2019/11/08 06:00
MHDA- 2020/03/24 06:00
PMCR- 2019/11/07
CRDT- 2019/11/08 06:00
PHST- 2019/08/07 00:00 [received]
PHST- 2019/10/23 00:00 [accepted]
PHST- 2019/11/08 06:00 [entrez]
PHST- 2019/11/08 06:00 [pubmed]
PHST- 2020/03/24 06:00 [medline]
PHST- 2019/11/07 00:00 [pmc-release]
AID - PONE-D-19-22245 [pii]
AID - 10.1371/journal.pone.0224859 [doi]
PST - epublish
SO  - PLoS One. 2019 Nov 7;14(11):e0224859. doi: 10.1371/journal.pone.0224859. 
      eCollection 2019.