PMID- 31698358
OWN - NLM
STAT- MEDLINE
DCOM- 20210716
LR  - 20210716
IS  - 1423-0151 (Electronic)
IS  - 1011-7571 (Print)
IS  - 1011-7571 (Linking)
VI  - 29
IP  - 4
DP  - 2020
TI  - Dentin Tubule Occlusion Potential of Novel Dentifrices Having Fluoride Containing 
      Bioactive Glass and Zinc Oxide Nanoparticles.
PG  - 338-346
LID - 10.1159/000503706 [doi]
AB  - OBJECTIVE: To compare the in vitro potential of dentin tubule occlusion of two 
      novel experimental dentifrices consisting of fluoride containing bioactive glass 
      (BG) with zinc oxide nanoparticles. MATERIALS AND METHODS: Forty-eight dentin 
      discs (n = 48) were divided into 6 groups (n = 8), based on their brushing 
      dentifrices: Group 1 = artificial saliva (AS; control); Group 2 = fluoride 
      dentifrice (Colgate Palmolive(c), UK); Group 3 = experimental nonactive agent 
      dentifrice; Group 4 = experimental dentifrice with 1.5% BG; Group 5 = 
      experimental dentifrice with 4% BG; and Group 6 = BioMinF(c) dentifrice. 
      Postbrushing, the discs were subjected to acidic challenge with 6% wt citric acid 
      (pH = 4.0) for 1 min. Scanning electron microscope (SEM) and energy-dispersive 
      X-ray (EDX) spectroscopy were performed pre- and post-citric acid challenges, and 
      percentages of tubule occlusion assessed. RESULTS: SEM micrographs of group 1 
      (AS) show no tubule occlusion (0%), whereas those of groups 2 and 3 show partial 
      tubule occlusion (25 to <50% of tubules occluded). The SEM micrographs of 
      dentifrices containing fluoride-BG (groups 4, 5, and 6) show that most of the 
      tubules (>50 and <100%) were occluded. For all the groups (excluding group 1), 
      pre- and post-citric acid challenge values are statistically significant (p < 
      0.05). EDX analysis reveals the presence of zinc in experimental dentifrices 
      only. CONCLUSION: The results of novel experimental dentifrices are comparable to 
      those of the BioMinF(c), in terms of tubule occlusion. Dentifrices containing BG 
      could serve as an alternative in dentin sensitivity management.
CI  - (c) 2019 The Author(s) Published by S. Karger AG, Basel.
FAU - Khan, Abdul Samad
AU  - Khan AS
AD  - Department of Restorative Dental Sciences, College of Dentistry, Imam Abdulrahman 
      Bin Faisal University, Dammam, Saudi Arabia.
FAU - Farooq, Imran
AU  - Farooq I
AD  - Department of Biomedical Dental Sciences, College of Dentistry, Imam Abdulrahman 
      Bin Faisal University, Dammam, Saudi Arabia, drimranfarooq@gmail.com.
FAU - Alakrawi, Kawther Moosa
AU  - Alakrawi KM
AD  - College of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam, Saudi 
      Arabia.
FAU - Khalid, Hina
AU  - Khalid H
AD  - Interdisciplinary Research Centre in Biomedical Materials, COMSATS University 
      Islamabad, Lahore Campus, Lahore, Pakistan.
FAU - Saadi, Omar Waqas
AU  - Saadi OW
AD  - Department of Mechanical Engineering, Khalifa University, Abu Dhabi, United Arab 
      Emirates.
FAU - Hakeem, Abbas Saeed
AU  - Hakeem AS
AD  - Center of Excellence in Nanotechnology, King Fahd University of Petroleum and 
      Minerals, Dhahran, Saudi Arabia.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20191105
PL  - Switzerland
TA  - Med Princ Pract
JT  - Medical principles and practice : international journal of the Kuwait University, 
      Health Science Centre
JID - 8901334
RN  - 0 (Dentifrices)
RN  - Q80VPU408O (Fluorides)
RN  - SOI2LOH54Z (Zinc Oxide)
SB  - IM
MH  - Dentifrices/*pharmacology
MH  - Dentin/*drug effects
MH  - Fluorides/*pharmacology
MH  - Glass
MH  - Humans
MH  - Microscopy, Electron, Scanning
MH  - Nanoparticles
MH  - Zinc Oxide/*pharmacology
PMC - PMC7445664
OTO - NOTNLM
OT  - Bioactive glass
OT  - Dentin sensitivity
OT  - Fluoride
OT  - Scanning electron microscopy
OT  - Zinc
COIS- The authors have no conflicts of interest to declare.
EDAT- 2019/11/08 06:00
MHDA- 2021/07/17 06:00
PMCR- 2019/11/05
CRDT- 2019/11/08 06:00
PHST- 2019/02/17 00:00 [received]
PHST- 2019/10/28 00:00 [accepted]
PHST- 2019/11/08 06:00 [pubmed]
PHST- 2021/07/17 06:00 [medline]
PHST- 2019/11/08 06:00 [entrez]
PHST- 2019/11/05 00:00 [pmc-release]
AID - 000503706 [pii]
AID - mpp-0029-0338 [pii]
AID - 10.1159/000503706 [doi]
PST - ppublish
SO  - Med Princ Pract. 2020;29(4):338-346. doi: 10.1159/000503706. Epub 2019 Nov 5.