PMID- 31698901
OWN - NLM
STAT- MEDLINE
DCOM- 20191230
LR  - 20191230
IS  - 1520-5118 (Electronic)
IS  - 0021-8561 (Linking)
VI  - 67
IP  - 50
DP  - 2019 Dec 18
TI  - A New Possible Mechanism by Which Punicalagin Protects against Liver Injury 
      Induced by Type 2 Diabetes Mellitus: Upregulation of Autophagy via the Akt/FoxO3a 
      Signaling Pathway.
PG  - 13948-13959
LID - 10.1021/acs.jafc.9b05910 [doi]
AB  - The aim of this study was to investigate the protective effect of punicalagin 
      (PU), which is a main component of pomegranate polyphenols, against liver injury 
      induced by Type 2 diabetes mellitus (T2DM) and to explore the molecular mechanism 
      based on autophagy in vivo and in vitro. In T2DM mice, we found that PU 
      significantly improved liver histology, reversed serum biochemical abnormalities, 
      and increased the autophagosome number in the liver. In HepG2 cells cultured in a 
      high-glucose environment, PU upregulated the glucose uptake level. Both in vivo 
      and in vitro, PU upregulated the expression of autophagy-related proteins, such 
      as LC3b and p62, and reduced the phosphorylated Akt/total Akt and phosphorylated 
      FoxO3a/total FoxO3a protein ratios, and these effects were enhanced by LY294002 
      (a PI3K/Akt inhibitor). In summary, our current findings suggest that PU protects 
      against liver injury induced by T2DM by restoring autophagy through the 
      Akt/FoxO3a signaling pathway.
FAU - Zhang, Yahui
AU  - Zhang Y
AD  - Xiangya School of Public Health , Central South University , Changsha 410128 , 
      China.
FAU - Cao, Yuan
AU  - Cao Y
AD  - Xiangya School of Public Health , Central South University , Changsha 410128 , 
      China.
FAU - Chen, Jihua
AU  - Chen J
AD  - Xiangya School of Public Health , Central South University , Changsha 410128 , 
      China.
FAU - Qin, Hong
AU  - Qin H
AUID- ORCID: 0000-0002-4578-5118
AD  - Xiangya School of Public Health , Central South University , Changsha 410128 , 
      China.
FAU - Yang, Lina
AU  - Yang L
AUID- ORCID: 0000-0002-9503-3344
AD  - Xiangya School of Public Health , Central South University , Changsha 410128 , 
      China.
LA  - eng
PT  - Journal Article
DEP - 20191209
PL  - United States
TA  - J Agric Food Chem
JT  - Journal of agricultural and food chemistry
JID - 0374755
RN  - 0 (Forkhead Box Protein O3)
RN  - 0 (Hydrolyzable Tannins)
RN  - 0 (Protective Agents)
RN  - 65995-63-3 (punicalagin)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
SB  - IM
MH  - Animals
MH  - Autophagy/*drug effects
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Forkhead Box Protein O3/genetics/*metabolism
MH  - Humans
MH  - Hydrolyzable Tannins/*administration & dosage
MH  - Liver/*injuries/metabolism
MH  - Liver Diseases/etiology/metabolism/physiopathology/*prevention & control
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Protective Agents/*administration & dosage
MH  - Proto-Oncogene Proteins c-akt/genetics/*metabolism
MH  - Signal Transduction/drug effects
OTO - NOTNLM
OT  - Akt/FoxO3a signaling pathway
OT  - T2DM
OT  - autophagy
OT  - liver injury
OT  - punicalagin
EDAT- 2019/11/09 06:00
MHDA- 2019/12/31 06:00
CRDT- 2019/11/09 06:00
PHST- 2019/11/09 06:00 [pubmed]
PHST- 2019/12/31 06:00 [medline]
PHST- 2019/11/09 06:00 [entrez]
AID - 10.1021/acs.jafc.9b05910 [doi]
PST - ppublish
SO  - J Agric Food Chem. 2019 Dec 18;67(50):13948-13959. doi: 10.1021/acs.jafc.9b05910. 
      Epub 2019 Dec 9.