PMID- 31699055
OWN - NLM
STAT- MEDLINE
DCOM- 20200309
LR  - 20200309
IS  - 1471-2415 (Electronic)
IS  - 1471-2415 (Linking)
VI  - 19
IP  - 1
DP  - 2019 Nov 7
TI  - Correlation between visual acuity and human leukocyte antigen DRB1*04 in patients 
      with Vogt-Koyanagi-Harada disease.
PG  - 214
LID - 10.1186/s12886-019-1227-6 [doi]
LID - 214
AB  - BACKGROUND: The common presence of human leukocyte antigen (HLA)-DRB1*04 in 
      Vogt-Koyanagi-Harada (VKH) disease is well known. The aim of this study was to 
      investigate the relationship between visual prognosis and HLA-DRB1*04 alleles 
      during systemic corticosteroid therapy in patients with VKH disease. METHODS: 
      This retrospective case series included 57 eyes from 29 consecutive patients with 
      treatment-naive VKH disease who received systemic corticosteroid therapy. Visual 
      acuity, sex, refractive error, central retinal thickness (CRT), central choroidal 
      thickness (CCT), and duration from onset to treatment were measured at initial 
      and final visits. Mean values of parameters were compared with each visit. 
      Genotyping was performed by polymerase chain reaction amplification with 
      sequence-specific primer. RESULTS: Linear regression showed significant 
      differences in logMAR best-corrected visual acuity between the three groups of 
      homozygotes, heterozygotes, and normal subjects at baseline (p < 0.01), at 3 
      months after treatment (p < 0.01). There was no significant differences at 6 
      months after treatment (p = 0.257). No significant differences were detected 
      between the three groups in age, sex, refractive error, CRT, CCT, or duration 
      from onset to treatment. CONCLUSION: Alleles of HLA-DRB1*04 might affect visual 
      prognosis and be related to early response after initiation of treatment in VKH 
      disease.
FAU - Misawa, Norihiko
AU  - Misawa N
AD  - Department of Ophthalmology and Visual Science, Graduate School of Medicine, 
      Osaka City University, 1-5-7 Asahimachi, Abeno-ku, Osaka-shi, 545-8586, Japan.
FAU - Tagami, Mizuki
AU  - Tagami M
AD  - Department of Ophthalmology and Visual Science, Graduate School of Medicine, 
      Osaka City University, 1-5-7 Asahimachi, Abeno-ku, Osaka-shi, 545-8586, Japan. 
      tagami.mizuki@med.osaka-cu.ac.jp.
FAU - Kohno, Takeya
AU  - Kohno T
AD  - Department of Ophthalmology and Visual Science, Graduate School of Medicine, 
      Osaka City University, 1-5-7 Asahimachi, Abeno-ku, Osaka-shi, 545-8586, Japan.
FAU - Honda, Shigeru
AU  - Honda S
AD  - Department of Ophthalmology and Visual Science, Graduate School of Medicine, 
      Osaka City University, 1-5-7 Asahimachi, Abeno-ku, Osaka-shi, 545-8586, Japan.
LA  - eng
PT  - Journal Article
DEP - 20191107
PL  - England
TA  - BMC Ophthalmol
JT  - BMC ophthalmology
JID - 100967802
RN  - 0 (Adrenal Cortex Hormones)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adrenal Cortex Hormones/therapeutic use
MH  - Adult
MH  - Choroid/pathology
MH  - Female
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Histocompatibility Testing
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Regression Analysis
MH  - Retina/pathology
MH  - Retrospective Studies
MH  - *Uveomeningoencephalitic Syndrome/drug therapy/genetics/physiopathology
MH  - Visual Acuity/*physiology
PMC - PMC6836542
OTO - NOTNLM
OT  - HLA-DRB1*04
OT  - Japanese patients
OT  - Vogt-Koyanagi-Harada disease
COIS- The authors declare that they have no competing interests.
EDAT- 2019/11/09 06:00
MHDA- 2020/03/10 06:00
PMCR- 2019/11/07
CRDT- 2019/11/09 06:00
PHST- 2019/07/04 00:00 [received]
PHST- 2019/10/28 00:00 [accepted]
PHST- 2019/11/09 06:00 [entrez]
PHST- 2019/11/09 06:00 [pubmed]
PHST- 2020/03/10 06:00 [medline]
PHST- 2019/11/07 00:00 [pmc-release]
AID - 10.1186/s12886-019-1227-6 [pii]
AID - 1227 [pii]
AID - 10.1186/s12886-019-1227-6 [doi]
PST - epublish
SO  - BMC Ophthalmol. 2019 Nov 7;19(1):214. doi: 10.1186/s12886-019-1227-6.