PMID- 31699565
OWN - NLM
STAT- MEDLINE
DCOM- 20210728
LR  - 20210728
IS  - 1879-3061 (Electronic)
IS  - 1043-2760 (Print)
IS  - 1043-2760 (Linking)
VI  - 31
IP  - 1
DP  - 2020 Jan
TI  - Pros and Cons of Chaperone-Mediated Autophagy in Cancer Biology.
PG  - 53-66
LID - S1043-2760(19)30208-5 [pii]
LID - 10.1016/j.tem.2019.09.007 [doi]
AB  - Autophagy contributes to cellular quality control and energetics through 
      lysosomal breakdown and recycling of essential cellular components. 
      Chaperone-mediated autophagy (CMA) adds to these autophagic functions the ability 
      to timely and selectively degrade single tagged proteins to terminate their 
      cellular function and, in this way, participate in the regulation of multiple 
      cellular processes. Many cancer cells upregulate CMA for protumorigenic and 
      prosurvival purposes. However, growing evidence supports a physiological role for 
      CMA in limiting malignant transformation. Understanding the mechanisms behind 
      this functional switch of CMA from antioncogenic to pro-oncogenic is fundamental 
      for targeting CMA in cancer treatment. We summarize current understanding of CMA 
      functions in cancer biology and discuss the basis for its context-dependent dual 
      role in oncogenesis.
CI  - Copyright (c) 2019 Elsevier Ltd. All rights reserved.
FAU - Arias, Esperanza
AU  - Arias E
AD  - Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, 
      USA; Marion Bessin Liver Research Center, Albert Einstein College of Medicine, 
      Bronx, NY 10461, USA; Institute for Aging Studies, Albert Einstein College of 
      Medicine, Bronx, NY 10461, USA. Electronic address: 
      esperanza.arias-perez@einstein.yu.edu.
FAU - Cuervo, Ana Maria
AU  - Cuervo AM
AD  - Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, 
      NY 10461, USA; Institute for Aging Studies, Albert Einstein College of Medicine, 
      Bronx, NY 10461, USA; Department of Development and Molecular Biology, Albert 
      Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address: 
      ana-maria.cuervo@einstein.yu.edu.
LA  - eng
GR  - U54 NS100717/NS/NINDS NIH HHS/United States
GR  - R01 AG021904/AG/NIA NIH HHS/United States
GR  - R01 DK124308/DK/NIDDK NIH HHS/United States
GR  - R37 AG021904/AG/NIA NIH HHS/United States
GR  - RF1 AG054108/AG/NIA NIH HHS/United States
GR  - R01 DK098408/DK/NIDDK NIH HHS/United States
GR  - P01 AG031782/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20191104
PL  - United States
TA  - Trends Endocrinol Metab
JT  - Trends in endocrinology and metabolism: TEM
JID - 9001516
SB  - IM
MH  - Animals
MH  - Carcinogenesis/metabolism
MH  - Chaperone-Mediated Autophagy/genetics/*physiology
MH  - Humans
MH  - Lysosomes/metabolism
MH  - Neoplasms/*metabolism/*pathology
PMC - PMC7020649
MID - NIHMS1542248
OTO - NOTNLM
OT  - chaperones
OT  - lysosomes
OT  - metabolism
OT  - oncogenes
OT  - protein degradation
OT  - tumorigenesis
EDAT- 2019/11/09 06:00
MHDA- 2021/07/29 06:00
PMCR- 2021/01/01
CRDT- 2019/11/09 06:00
PHST- 2019/08/02 00:00 [received]
PHST- 2019/09/16 00:00 [revised]
PHST- 2019/09/17 00:00 [accepted]
PHST- 2019/11/09 06:00 [pubmed]
PHST- 2021/07/29 06:00 [medline]
PHST- 2019/11/09 06:00 [entrez]
PHST- 2021/01/01 00:00 [pmc-release]
AID - S1043-2760(19)30208-5 [pii]
AID - 10.1016/j.tem.2019.09.007 [doi]
PST - ppublish
SO  - Trends Endocrinol Metab. 2020 Jan;31(1):53-66. doi: 10.1016/j.tem.2019.09.007. 
      Epub 2019 Nov 4.