PMID- 31700711
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 11
IP  - 9
DP  - 2019 Sep 9
TI  - Adalimumab-induced Anti-neutrophilic Cytoplasmic Antibody Vasculitis: A Rare 
      Complication of an Increasingly Common Treatment.
PG  - e5598
LID - 10.7759/cureus.5598 [doi]
LID - e5598
AB  - Tumor necrosis factor (TNF) inhibitors are used for treatment of different 
      autoimmune diseases. Interestingly they are also being noted to cause autoimmune 
      side effects such as vasculitis, systemic lupus erythematosus, interstitial lung 
      disease, etc. We describe one such case of granuloma annulare being treated with 
      Adalimumab, who then developed pulmonary-renal syndrome form anti-neutrophilic 
      cytoplasmic antibody (ANCA)-induced vasculitis. This was treated with steroids 
      and immunosuppression, as well as discontinuation of the TNF inhibitor. However, 
      he remains dependant on dialysis and immunosuppression. In this article, we 
      review the existing literature on clinical presentation and course of TNF 
      inhibitors-induced ANCA vasculitis. We also discuss the underlying mechanisms 
      thought to be responsible for this.
CI  - Copyright (c) 2019, Chandra et al.
FAU - Chandra, Tanya
AU  - Chandra T
AD  - Internal Medicine, University of Connecticut Health Center, Farmington, USA.
FAU - Tabanor-Gayle, Joy-Ann
AU  - Tabanor-Gayle JA
AD  - Rheumatology, University of Connecticut Health Center, Farmington, USA.
FAU - Lakshminarayanan, Santhanam
AU  - Lakshminarayanan S
AD  - Rheumatology, University of Connecticut Health Center, Farmington, USA.
LA  - eng
PT  - Case Reports
DEP - 20190909
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC6822873
OTO - NOTNLM
OT  - adverse drug reactions
OT  - anca vasculitis
OT  - tnf inhibitor
COIS- The authors have declared that no competing interests exist.
EDAT- 2019/11/09 06:00
MHDA- 2019/11/09 06:01
PMCR- 2019/09/09
CRDT- 2019/11/09 06:00
PHST- 2019/11/09 06:00 [entrez]
PHST- 2019/11/09 06:00 [pubmed]
PHST- 2019/11/09 06:01 [medline]
PHST- 2019/09/09 00:00 [pmc-release]
AID - 10.7759/cureus.5598 [doi]
PST - epublish
SO  - Cureus. 2019 Sep 9;11(9):e5598. doi: 10.7759/cureus.5598.