PMID- 31700893
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220411
IS  - 2305-5839 (Print)
IS  - 2305-5847 (Electronic)
IS  - 2305-5839 (Linking)
VI  - 7
IP  - 18
DP  - 2019 Sep
TI  - Associations of serum sex hormone binding globulin with bone mineral densities 
      and higher 10-year probability of fractures in postmenopausal women with type 2 
      diabetes mellitus.
PG  - 457
LID - 10.21037/atm.2019.08.46 [doi]
LID - 457
AB  - BACKGROUND: Postmenopause and type 2 diabetes mellitus (T2DM) are associated with 
      higher fracture risk. Sex hormones are important in maintaining woman skeleton 
      health. The relationships of sex hormone(s) with bone mineral density (BMD) and 
      fracture risk are still unclear in diabetic-postmenopausal women. This study 
      aimed to investigate the relationships of sex hormones with BMDs and fracture 
      risk in postmenopausal women with T2DM. METHODS: Two hundred and fourteen 
      postmenopausal women with T2DM were included. BMDs at lumbar spine (L2-4), 
      femoral neck (FN) and total hip (TH) were measured by dual-energy X-ray 
      absorptiometry (DXA). The 10-year probability of fractures was accessed by 
      modified fracture risk algorithm (FRAX) tool. Serum concentrations of sex 
      hormones were measured. RESULTS: Sex hormone binding globulin (SHBG) was a 
      determinant of BMDs at L2-4 (beta=-0.199, P<0.05), TH (beta=-0.233, P<0.05), major 
      osteoporotic fracture (MOF) (beta=0.253, P<0.001) and hip fracture (HF) (beta=0.262, 
      P<0.001). Per SD increase in SHBG caused a 2% increase in the risk of 
      osteoporosis/osteopenia. SHBG in quartile-4 was associated with 4.21 higher risk 
      of osteoporosis/osteopenia compared with SHBG in quartile-1. CONCLUSIONS: In 
      postmenopausal women with T2DM, higher serum SHBG tended to be associated with 
      lower BMDs, and increased the risk of osteoporosis/osteopenia and the fracture 
      risk.
CI  - 2019 Annals of Translational Medicine. All rights reserved.
FAU - Jing, Yixuan
AU  - Jing Y
AD  - Department of Endocrine and Metabolic Diseases, Rui Jin Hospital, Shanghai 
      Jiao-tong University School of Medicine, Shanghai Institute of Endocrine and 
      Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic 
      Diseases, Shanghai 200025, China.
FAU - Wang, Xiaofeng
AU  - Wang X
AD  - Department of Endocrine and Metabolic Diseases, Rui Jin Hospital, Shanghai 
      Jiao-tong University School of Medicine, Shanghai Institute of Endocrine and 
      Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic 
      Diseases, Shanghai 200025, China.
AD  - Currently at Tong Ren Hospital, Shanghai Jiao-tong University School of Medicine, 
      Shanghai 200336, China.
FAU - Yu, Jingjia
AU  - Yu J
AD  - Department of Endocrine and Metabolic Diseases, Rui Jin Hospital, Shanghai 
      Jiao-tong University School of Medicine, Shanghai Institute of Endocrine and 
      Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic 
      Diseases, Shanghai 200025, China.
FAU - Wang, Xiaojing
AU  - Wang X
AD  - Department of Endocrine and Metabolic Diseases, Rui Jin Hospital, Shanghai 
      Jiao-tong University School of Medicine, Shanghai Institute of Endocrine and 
      Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic 
      Diseases, Shanghai 200025, China.
FAU - Zhou, Yanman
AU  - Zhou Y
AD  - Department of Endocrine and Metabolic Diseases, Rui Jin Hospital, Shanghai 
      Jiao-tong University School of Medicine, Shanghai Institute of Endocrine and 
      Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic 
      Diseases, Shanghai 200025, China.
FAU - Tao, Bei
AU  - Tao B
AD  - Department of Endocrine and Metabolic Diseases, Rui Jin Hospital, Shanghai 
      Jiao-tong University School of Medicine, Shanghai Institute of Endocrine and 
      Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic 
      Diseases, Shanghai 200025, China.
FAU - Sun, Lihao
AU  - Sun L
AD  - Department of Endocrine and Metabolic Diseases, Rui Jin Hospital, Shanghai 
      Jiao-tong University School of Medicine, Shanghai Institute of Endocrine and 
      Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic 
      Diseases, Shanghai 200025, China.
FAU - Liu, Jianmin
AU  - Liu J
AD  - Department of Endocrine and Metabolic Diseases, Rui Jin Hospital, Shanghai 
      Jiao-tong University School of Medicine, Shanghai Institute of Endocrine and 
      Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic 
      Diseases, Shanghai 200025, China.
FAU - Zhao, Hongyan
AU  - Zhao H
AD  - Department of Endocrine and Metabolic Diseases, Rui Jin Hospital, Shanghai 
      Jiao-tong University School of Medicine, Shanghai Institute of Endocrine and 
      Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic 
      Diseases, Shanghai 200025, China.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Ann Transl Med
JT  - Annals of translational medicine
JID - 101617978
PMC - PMC6803194
OTO - NOTNLM
OT  - Bone mineral density (BMD)
OT  - postmenopause
OT  - sex hormone binding globulin (SHBG)
OT  - type 2 diabetes mellitus (T2DM)
COIS- Conflicts of Interest: The authors have no conflicts of interest to declare.
EDAT- 2019/11/09 06:00
MHDA- 2019/11/09 06:01
PMCR- 2019/09/01
CRDT- 2019/11/09 06:00
PHST- 2019/11/09 06:00 [entrez]
PHST- 2019/11/09 06:00 [pubmed]
PHST- 2019/11/09 06:01 [medline]
PHST- 2019/09/01 00:00 [pmc-release]
AID - atm-07-18-457 [pii]
AID - 10.21037/atm.2019.08.46 [doi]
PST - ppublish
SO  - Ann Transl Med. 2019 Sep;7(18):457. doi: 10.21037/atm.2019.08.46.