PMID- 31700919
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220411
IS  - 2305-5839 (Print)
IS  - 2305-5847 (Electronic)
IS  - 2305-5839 (Linking)
VI  - 7
IP  - 18
DP  - 2019 Sep
TI  - Predicting significance of COX-2 expression of peripheral blood monocyte in 
      patients with coronary artery disease.
PG  - 483
LID - 10.21037/atm.2019.08.75 [doi]
LID - 483
AB  - BACKGROUND: Cyclooxygenase-2 (COX-2) plays an important role in the 
      monocyte-platelet aggregate (MPA)-medicated inflammatory response and possible 
      coronary artery disease (CAD). This study aimed to assess the predicting 
      significance of COX-2 expression in peripheral blood monocyte for CAD. METHODS: A 
      total of 66 patients with CAD including stable angina (SA) and unstable angina 
      (UA) were enrolled. The inflammatory indexes including white blood cell (WBC) 
      count, high-sensitive C reactive protein (hs-CRP), serum monocyte chemoattractant 
      protein-1 (MCP-1) and MPA levels were measured. The western-blotting assay and 
      reverse transcription-polymerase chain reaction (RT-PCR) analysis were used to 
      detect the COX-2 expression in peripheral blood monocytes. Furthermore, the 
      correlation between COX-2 expression and MPA levels, and the association of COX-2 
      expression with CAD risk were assessed. RESULTS: The UA patients demonstrated 
      higher levels of inflammatory indexes than the SA patients (P<0.001). 
      Simultaneously, higher MPA levels and enhanced COX-2 expression were observed in 
      the UA patients (P<0.01). The patients with enhanced COX-2 expression exhibited 
      higher MPA than those without (P<0.01), and patients with increased MPA also 
      demonstrated enhanced COX-2 expression (P<0.001). Moreover, the levels of COX-2 
      protein expression was positively related to the MPA formation rates 
      (R(2)=0.4933, P<0.01), and enhanced COX-2 expression was independently associated 
      with CAD risk [odds ratio (OR): 6.322, 95% confidence interval (CI): 4.544-8.978 
      ]. CONCLUSIONS: The COX-2 expression of peripheral blood monocytes can be used as 
      an independent predictor for CAD.
CI  - 2019 Annals of Translational Medicine. All rights reserved.
FAU - Huang, Qinghua
AU  - Huang Q
AD  - Department of Endocrinology, Zhejiang Provincial People's Hospital and People's 
      Hospital of Hangzhou Medical College, Hangzhou 310014, China.
FAU - Fei, Xianming
AU  - Fei X
AD  - Center for Laboratory Medicine, Zhejiang Provincial People's Hospital and 
      People's Hospital of Hangzhou Medical College, Hangzhou 310014, China.
FAU - Li, Shengbing
AU  - Li S
AD  - Department of Laboratory Medicine, The Second Jiaxing Hospital, Jiaxing 314000, 
      China.
FAU - Xu, Chan
AU  - Xu C
AD  - Department of Laboratory Medicine, Zhejiang Provincial Zhongshan Hospital, 
      Hangzhou 330106, China.
FAU - Tu, Chunping
AU  - Tu C
AD  - Department of Laboratory Medicine, Nanxun People's Hospital of Huzhou, Huzhou 
      313009, China.
FAU - Jiang, Lei
AU  - Jiang L
AD  - Center for Laboratory Medicine, Zhejiang Provincial People's Hospital and 
      People's Hospital of Hangzhou Medical College, Hangzhou 310014, China.
FAU - Wo, Mingyi
AU  - Wo M
AD  - Center for Laboratory Medicine, Zhejiang Provincial People's Hospital and 
      People's Hospital of Hangzhou Medical College, Hangzhou 310014, China.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Ann Transl Med
JT  - Annals of translational medicine
JID - 101617978
PMC - PMC6803216
OTO - NOTNLM
OT  - Coronary artery disease (CAD)
OT  - cyclooxygenase-2 (COX-2)
OT  - monocyte
OT  - predictor
COIS- Conflicts of Interest: The authors have no conflicts of interest to declare.
EDAT- 2019/11/09 06:00
MHDA- 2019/11/09 06:01
PMCR- 2019/09/01
CRDT- 2019/11/09 06:00
PHST- 2019/11/09 06:00 [entrez]
PHST- 2019/11/09 06:00 [pubmed]
PHST- 2019/11/09 06:01 [medline]
PHST- 2019/09/01 00:00 [pmc-release]
AID - atm-07-18-483 [pii]
AID - 10.21037/atm.2019.08.75 [doi]
PST - ppublish
SO  - Ann Transl Med. 2019 Sep;7(18):483. doi: 10.21037/atm.2019.08.75.