PMID- 31701229 OWN - NLM STAT- MEDLINE DCOM- 20201207 LR - 20210210 IS - 1615-2573 (Electronic) IS - 0910-8327 (Linking) VI - 35 IP - 5 DP - 2020 May TI - Clinical significance of rectus femoris diameter in heart failure patients. PG - 672-680 LID - 10.1007/s00380-019-01534-7 [doi] AB - Heart failure (HF) is often accompanied by skeletal muscle weakness and exercise intolerance, which are known as prognostic factors of HF. Comprehensive evaluation of physical function is important, but it is not commonly conducted because of the lack of equipment or appropriate expertise. Measurement of rectus femoris diameter (RFD) by ultrasound is convenient and noninvasive, but it has not been clarified that RFD could represent physical functions in HF patients. This study evaluated 185 consecutive HF patients and underwent assessment including RFD, grip power (GP), knee extension strength (KES), skeletal muscle index (SMI), nutrition status, cardiopulmonary exercise testing, and New York Heart Association (NYHA) functional class. RFD was related with NYHA class and significantly correlated with GP, KES, SMI, body mass index, pre-albumin level, geriatric nutritional risk index, and peak VO(2) (r = 0.631, 0.676, 0.510, 0.568, 0.380, 0.539, 0.527, respectively; p < 0.001). Multivariate regression analysis revealed that estimated glomerular filtration rate (beta = 0.551) and RFD (beta = 0.326) were predictive factors of peak VO(2). Gender, age, brain natriuretic peptide level, left ventricular ejection fraction, and hemoglobin level were the other explanatory parameters. The cut off value of RFD for sarcopenia diagnosis was estimated as 15 mm (sensitivity = 0.767 and specificity = 0.808). RFD is a simple and useful marker which reflects skeletal muscle strength/volume, exercise tolerance, nutrition status, and NYHA class. It is also associated with sarcopenia in HF patients. FAU - Sato, Yoshimi AU - Sato Y AD - Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kajii-cho 465, Kamigyo-ku, Kyoto, 602-8566, Japan. FAU - Shiraishi, Hirokazu AU - Shiraishi H AD - Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kajii-cho 465, Kamigyo-ku, Kyoto, 602-8566, Japan. siraisih@koto.kpu-m.ac.jp. FAU - Nakanishi, Naohiko AU - Nakanishi N AD - Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kajii-cho 465, Kamigyo-ku, Kyoto, 602-8566, Japan. FAU - Zen, Kan AU - Zen K AD - Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kajii-cho 465, Kamigyo-ku, Kyoto, 602-8566, Japan. FAU - Nakamura, Takeshi AU - Nakamura T AD - Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kajii-cho 465, Kamigyo-ku, Kyoto, 602-8566, Japan. FAU - Yamano, Tetsuhiro AU - Yamano T AD - Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kajii-cho 465, Kamigyo-ku, Kyoto, 602-8566, Japan. FAU - Shirayama, Takeshi AU - Shirayama T AD - Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kajii-cho 465, Kamigyo-ku, Kyoto, 602-8566, Japan. FAU - Matoba, Satoaki AU - Matoba S AD - Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kajii-cho 465, Kamigyo-ku, Kyoto, 602-8566, Japan. LA - eng PT - Journal Article DEP - 20191107 PL - Japan TA - Heart Vessels JT - Heart and vessels JID - 8511258 SB - IM MH - Adult MH - Aged MH - Aged, 80 and over MH - Cardiorespiratory Fitness MH - Exercise Test MH - *Exercise Tolerance MH - Female MH - Hand Strength MH - Heart Failure/*diagnostic imaging/physiopathology MH - Humans MH - Male MH - Middle Aged MH - *Muscle Strength MH - Nutritional Status MH - Oxygen Consumption MH - Predictive Value of Tests MH - Quadriceps Muscle/*diagnostic imaging/physiopathology MH - Sarcopenia/*diagnostic imaging/physiopathology MH - *Ultrasonography OTO - NOTNLM OT - Exercise tolerance OT - Heart failure OT - Rectus femoris muscle OT - Sarcopenia EDAT- 2019/11/09 06:00 MHDA- 2020/12/15 06:00 CRDT- 2019/11/09 06:00 PHST- 2019/07/17 00:00 [received] PHST- 2019/11/01 00:00 [accepted] PHST- 2019/11/09 06:00 [pubmed] PHST- 2020/12/15 06:00 [medline] PHST- 2019/11/09 06:00 [entrez] AID - 10.1007/s00380-019-01534-7 [pii] AID - 10.1007/s00380-019-01534-7 [doi] PST - ppublish SO - Heart Vessels. 2020 May;35(5):672-680. doi: 10.1007/s00380-019-01534-7. Epub 2019 Nov 7.