PMID- 31701359
OWN - NLM
STAT- MEDLINE
DCOM- 20210120
LR  - 20221207
IS  - 1573-742X (Electronic)
IS  - 0929-5305 (Linking)
VI  - 49
IP  - 3
DP  - 2020 Apr
TI  - Identifying optimal heparin management during cardiopulmonary bypass in Chinese 
      people: a retrospective observational comparative study.
PG  - 480-486
LID - 10.1007/s11239-019-01987-7 [doi]
AB  - Traditionally heparin is adapted according to total body weight (TBW) to 
      providing anticoagulation during cardiopulmonary bypass (CPB), but it may be 
      inaccurate in some patients. The medical records of 100 adult patients who 
      received CPB in Tongji Hospital of Tongji Medical College Huazhong University of 
      Science and Technology over a 10-month period in 2017 were included in the 
      retrospective study. An unfractionated heparin (UFH) bolus of 300 IU/kg TBW was 
      injected before initiation of CPB followed by additional doses (50 to 100 IU/kg) 
      to maintain a target activated coagulation time (ACT) of at least 480 s. We used 
      TBW, ideal body weight (IBW), lean body weight (LBW), or body mass index (BMI) to 
      establish and evaluate a linear model of ACT and the amount of heparin 
      respectively. The linear fit effect of the model based on BMI on the original 
      data is better than the others. As the instruments to measure heparin 
      concentration is unavailable in most medical institutions in China. The new 
      linear model based on BMI is helpful to estimate a more individualized heparin 
      dosage in the heparinized phase and to provide useful reference to the amount of 
      remaining heparin in the neutralization phase.
FAU - Gan, Yongbo
AU  - Gan Y
AD  - School of Mathematics and Statistics, Wuhan University, Wuhan, 430072, Hubei, 
      China.
FAU - Yang, Zhijian
AU  - Yang Z
AD  - School of Mathematics and Statistics, Wuhan University, Wuhan, 430072, Hubei, 
      China.
FAU - Mei, Wei
AU  - Mei W
AD  - Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430030, Hubei, China.
FAU - Zhu, Chang
AU  - Zhu C
AD  - Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430030, Hubei, China. 
      changzhu@hust.edu.cn.
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Observational Study
PL  - Netherlands
TA  - J Thromb Thrombolysis
JT  - Journal of thrombosis and thrombolysis
JID - 9502018
RN  - 0 (Anticoagulants)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Adult
MH  - *Anticoagulants/administration & dosage/pharmacokinetics
MH  - Asian People
MH  - *Cardiopulmonary Bypass
MH  - China
MH  - Female
MH  - *Heparin/administration & dosage/pharmacokinetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Models, Cardiovascular
MH  - Retrospective Studies
OTO - NOTNLM
OT  - Anticoagulants
OT  - Body mass index
OT  - Cardiopulmonary bypass
OT  - Heparin
EDAT- 2019/11/09 06:00
MHDA- 2021/01/21 06:00
CRDT- 2019/11/09 06:00
PHST- 2019/11/09 06:00 [pubmed]
PHST- 2021/01/21 06:00 [medline]
PHST- 2019/11/09 06:00 [entrez]
AID - 10.1007/s11239-019-01987-7 [pii]
AID - 10.1007/s11239-019-01987-7 [doi]
PST - ppublish
SO  - J Thromb Thrombolysis. 2020 Apr;49(3):480-486. doi: 10.1007/s11239-019-01987-7.