PMID- 31703409
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 8
IP  - 11
DP  - 2019 Nov 7
TI  - Systematic Balance Exercises Influence Cortical Activation and Serum BDNF Levels 
      in Older Adults.
LID - 10.3390/jcm8111910 [doi]
LID - 1910
AB  - : We sought to investigate whether systematic balance training modulates brain 
      area activity responsible for postural control and influence brain-derived 
      neurotrophic factor (BDNF) mRNA protein expression. Seventy-four older adults 
      were randomly divided into three groups (mean age 65.34 +/- 3.79 years, 30 
      females): Classic balance exercises (CBT), virtual reality balance exercises 
      (VBT), and control (CON). Neuroimaging studies were performed at inclusion and 
      after completion of the training or 12 weeks later (CON). Blood samples were 
      obtained to measure BDNF expression. The study revealed significant interaction 
      of sessions and groups: In the motor imagery (MI) condition for supplementary 
      motor area (SMA) activity (F(at peak) = 5.25, p < 0.05); in the action 
      observation (AO) condition for left and right supramarginal gyrus/posterior 
      insula (left: F(at peak) = 6.48, p < 0.05; right: F(at peak) = 6.92, p < 0.05); 
      in the action observation together with motor imagery (AOMI) condition for the 
      middle occipital gyrus (laterally)/area V5 (left: F(at peak) = 6.26, p < 0.05; 
      right: F(at peak) = 8.37, p < 0.05), and in the cerebellum-inferior semilunar 
      lobule/tonsil (F(at peak) = 5.47, p < 0.05). After the training serum BDNF level 
      has increased in CBT (p < 0.001) and in CBT compared to CON (p < 0.05). 
      Systematic balance training may reverse the age-related cortical over-activations 
      and appear to be a factor mediating neuroplasticity in older adults.
FAU - Kubica, Jadwiga
AU  - Kubica J
AD  - Institute of Physiotherapy, Faculty of Health Science, Jagiellonian University 
      Medical College, 31-126 Krakow, Poland.
FAU - Szymura, Jadwiga
AU  - Szymura J
AD  - Department of Clinical Rehabilitation, Faculty of Motor Rehabilitation, 
      University of Physical Education in Krakow, 31-571 Krakow, Poland.
FAU - Domagalik, Aleksandra
AU  - Domagalik A
AD  - Brain Imaging Core Facility, Malopolska Centre of Biotechnology, Jagiellonian 
      University, 30-387 Krakow, Poland.
FAU - Golda, Slawomir
AU  - Golda S
AD  - Department of Molecular Neuropharmacology, Institute of Pharmacology, Polish 
      Academy of Sciences, 31-343 Krakow, Poland.
FAU - Wiecek, Magdalena
AU  - Wiecek M
AD  - Department of Physiology and Biochemistry, Faculty of Physical Education and 
      Sport, University of Physical Education in Krakow, 31-571 Krakow, Poland.
FAU - Fafrowicz, Magdalena
AU  - Fafrowicz M
AD  - Department of Cognitive Neuroscience and Neuroergonomics, Institute of Applied 
      Psychology, Jagiellonian University, 30-348 Krakow, Poland.
FAU - Marek, Tadeusz
AU  - Marek T
AD  - Department of Cognitive Neuroscience and Neuroergonomics, Institute of Applied 
      Psychology, Jagiellonian University, 30-348 Krakow, Poland.
FAU - Pera, Joanna
AU  - Pera J
AD  - Department of Neurology, Faculty of Medicine, Jagiellonian University Medical 
      College, 31-503 Krakow, Poland.
LA  - eng
GR  - 2014/15/N/NZ7/02970/National Science Center/
GR  - K/ZDS/006181/Jagiellonian University Medical College grant/
PT  - Journal Article
DEP - 20191107
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC6912622
OTO - NOTNLM
OT  - balance training
OT  - fMRI
OT  - neuroplasticity
OT  - older adult
COIS- The authors declare no conflict of interest. The funders had no role in the 
      design of the study; in the collection, analyses, or interpretation of data; in 
      the writing of the manuscript, or in the decision to publish the results.
EDAT- 2019/11/11 06:00
MHDA- 2019/11/11 06:01
PMCR- 2019/11/07
CRDT- 2019/11/10 06:00
PHST- 2019/09/20 00:00 [received]
PHST- 2019/10/23 00:00 [revised]
PHST- 2019/11/05 00:00 [accepted]
PHST- 2019/11/10 06:00 [entrez]
PHST- 2019/11/11 06:00 [pubmed]
PHST- 2019/11/11 06:01 [medline]
PHST- 2019/11/07 00:00 [pmc-release]
AID - jcm8111910 [pii]
AID - jcm-08-01910 [pii]
AID - 10.3390/jcm8111910 [doi]
PST - epublish
SO  - J Clin Med. 2019 Nov 7;8(11):1910. doi: 10.3390/jcm8111910.