PMID- 31703438
OWN - NLM
STAT- MEDLINE
DCOM- 20200323
LR  - 20200323
IS  - 1660-4601 (Electronic)
IS  - 1661-7827 (Print)
IS  - 1660-4601 (Linking)
VI  - 16
IP  - 22
DP  - 2019 Nov 7
TI  - Risk of Cardiovascular Mortality in Relation to Increased Total Serum IgE Levels 
      in Older Adults: A Population-Based Cohort Study.
LID - 10.3390/ijerph16224350 [doi]
LID - 4350
AB  - Background: Despite a potential link between immunoglobulin E (IgE) levels and 
      cardiovascular disease, the effect of elevated total IgE levels on long-term 
      mortality risk remains unclear. We prospectively investigated the association 
      between total serum IgE levels and all-cause and cardiovascular mortality in US 
      adults. Methods: We analyzed data from the 2005-2006 National Health and 
      Nutrition Examination Survey (NHANES) and the NHANES (2005-2006) Linked Mortality 
      Public File. The 2005-2006 NHANES data of 1496 older adults aged >/=50 years and 
      who underwent a serum total IgE antibody test in the initial survey were 
      included. Results: After a median follow-up of 119 months, a significant 
      association was observed between total serum IgE levels and cardiovascular 
      mortality, with subjects with the highest total IgE exhibiting a 3.19-fold (HR = 
      3.19; 95% confidence interval: 1.71-5.96) increase in the risk of cardiovascular 
      mortality compared with those with the lowest total IgE (</=16.80 kU/L). 
      Furthermore, the mortality rate increased with an increase in total IgE levels, 
      regardless of baseline history of cardiovascular diseases (e.g., myocardial 
      infarction, stroke, and noninvasively diagnosed large-vessel peripheral arterial 
      disease). Conclusions: This finding suggests that the elevation of IgE levels may 
      be a risk factor for increased cardiovascular mortality.
FAU - Min, Kyoung-Bok
AU  - Min KB
AD  - Department of Preventive Medicine, Colleague of Medicine, Seoul National 
      University, Seoul 08826, Korea.
FAU - Min, Jin-Young
AU  - Min JY
AD  - Institute of Health and Environment, School of Public Health, Seoul National 
      University, Seoul 08826, Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20191107
PL  - Switzerland
TA  - Int J Environ Res Public Health
JT  - International journal of environmental research and public health
JID - 101238455
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Cardiovascular Diseases/blood/*immunology/*mortality
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Immunologic Tests
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction
MH  - Nutrition Surveys
MH  - Prospective Studies
MH  - Risk Factors
MH  - United States/epidemiology
PMC - PMC6888246
OTO - NOTNLM
OT  - cardiovascular disease
OT  - cause of death
OT  - immunoglobulin E
OT  - population-based cohort
OT  - premature death
COIS- The authors declare no conflict of interest.
EDAT- 2019/11/11 06:00
MHDA- 2020/03/24 06:00
PMCR- 2019/11/01
CRDT- 2019/11/10 06:00
PHST- 2019/10/04 00:00 [received]
PHST- 2019/11/01 00:00 [revised]
PHST- 2019/11/03 00:00 [accepted]
PHST- 2019/11/10 06:00 [entrez]
PHST- 2019/11/11 06:00 [pubmed]
PHST- 2020/03/24 06:00 [medline]
PHST- 2019/11/01 00:00 [pmc-release]
AID - ijerph16224350 [pii]
AID - ijerph-16-04350 [pii]
AID - 10.3390/ijerph16224350 [doi]
PST - epublish
SO  - Int J Environ Res Public Health. 2019 Nov 7;16(22):4350. doi: 
      10.3390/ijerph16224350.