PMID- 31703530
OWN - NLM
STAT- MEDLINE
DCOM- 20191129
LR  - 20200108
IS  - 0008-7335 (Print)
IS  - 0008-7335 (Linking)
VI  - 158
IP  - 5
DP  - 2019 Fall
TI  - Metabolic disorders and sleep.
PG  - 185-192
AB  - Epidemiologic studies show that both atypical sleep time and obstructive sleep 
      apnea (OSA) are independently associated with higher risk of metabolic disease 
      development, particularly obesity and type 2 diabetes mellitus (T2DM). OSA is an 
      independent risk factor for cardiovascular mortality, which is amongst the most 
      common causes of death in T2DM. It is advisable to screen patients for OSA due to 
      the high prevalence of the disease in T2DM patients. For screening are 
      recommended questionnaires and home sleep monitoring. OSA diagnosis is then 
      verified by home sleep apnea testing (using polygraphy) or by polysomnography. 
      Positive airway pressure (PAP) is a gold standard in the treatment of moderate 
      and severe OSA. PAP prevents hypoxia and sleep fragmentation, eliminating 
      excessive daytime sleepiness and decreasing the risk of cardiovascular diseases. 
      Studies have not yet shown an effect of PAP treatment on T2DM compensation and 
      glucose metabolism. Despite this a positive effect of PAP on insulin resistance 
      and glucose tolerance has been proven in patients with prediabetes. PAP therapy 
      is advised in obese patients of the central type with OSA, bariatric surgery has 
      been proven to decrease the severity of OSA.
FAU - Pretl, Martin
AU  - Pretl M
FAU - Lattova, Zuzana
AU  - Lattova Z
FAU - Polak, Andrea Plihalovajan
AU  - Polak AP
FAU - Westlake, Katerina
AU  - Westlake K
LA  - eng
PT  - Journal Article
TT  - Metabolicke poruchy a spanek.
PL  - Czech Republic
TA  - Cas Lek Cesk
JT  - Casopis lekaru ceskych
JID - 0004743
SB  - IM
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Humans
MH  - *Insulin Resistance
MH  - Obesity
MH  - Polysomnography
MH  - *Sleep Apnea, Obstructive/complications
OTO - NOTNLM
OT  - central obesity
OT  - continuous positive airway pressure
OT  - glucose metabolism
OT  - intermittent hypoxia
OT  - obstructive sleep apnea
OT  - screening
OT  - sleep time
OT  - type 2 diabetes mellitus
EDAT- 2019/11/11 06:00
MHDA- 2019/11/30 06:00
CRDT- 2019/11/10 06:00
PHST- 2019/11/10 06:00 [entrez]
PHST- 2019/11/11 06:00 [pubmed]
PHST- 2019/11/30 06:00 [medline]
AID - 116567 [pii]
PST - ppublish
SO  - Cas Lek Cesk. 2019 Fall;158(5):185-192.