PMID- 31704068 OWN - NLM STAT- MEDLINE DCOM- 20200221 LR - 20200221 IS - 1873-7072 (Electronic) IS - 0308-8146 (Linking) VI - 309 DP - 2020 Mar 30 TI - Characterization, antioxidant activity, and inhibitory effect on pancreatic lipase of extracts from the edible insects Acheta domesticus and Tenebrio molitor. PG - 125742 LID - S0308-8146(19)31873-4 [pii] LID - 10.1016/j.foodchem.2019.125742 [doi] AB - Extracts from the edible insects Acheta domesticus and Tenebrio molitor were obtained by ultrasound-assisted extraction (UAE) and pressurized-liquid extraction (PLE) using ethanol (E) or ethanol:water (E:W). Characterization by GC-MS was performed and total phenolic compounds (TPC), antioxidant activity (DPPH) and pancreatic lipase inhibitory capacity were assayed. Most extracts, mainly ethanolic extracts, predominantly presented lipids as free fatty acids, followed by aminoacids, organic acids, carbohydrates, hydrocarbons and sterols. The UAE-E:W extracts were different, being characterized by organic acids for A. domesticus, or aminoacids for T. molitor. All the extracts exhibited antioxidant activity, which correlated with TPC values, being the E:W extracts the most effective. All the extracts showed inhibitory activity of lipase, although those from T. molitor and extracted by PLE were the most effective. Therefore, bioactive insect extracts can be selectively obtained by advanced methods of extraction, being aqueous ethanol preferred for antioxidant activity and PLE for inhibitory lipase activity. CI - Copyright (c) 2019 Elsevier Ltd. All rights reserved. FAU - Navarro Del Hierro, Joaquin AU - Navarro Del Hierro J AD - Departamento de Produccion y Caracterizacion de Nuevos Alimentos, Instituto de Investigacion en Ciencias de la Alimentacion (CIAL) (CSIC-UAM), 28049 Madrid, Spain; Seccion Departamental de Ciencias de la Alimentacion, Facultad de Ciencias, Universidad Autonoma de Madrid, 28049 Madrid, Spain. FAU - Gutierrez-Docio, Alba AU - Gutierrez-Docio A AD - Departamento de Produccion y Caracterizacion de Nuevos Alimentos, Instituto de Investigacion en Ciencias de la Alimentacion (CIAL) (CSIC-UAM), 28049 Madrid, Spain; Seccion Departamental de Ciencias de la Alimentacion, Facultad de Ciencias, Universidad Autonoma de Madrid, 28049 Madrid, Spain. FAU - Otero, Paz AU - Otero P AD - Departamento de Produccion y Caracterizacion de Nuevos Alimentos, Instituto de Investigacion en Ciencias de la Alimentacion (CIAL) (CSIC-UAM), 28049 Madrid, Spain; Seccion Departamental de Ciencias de la Alimentacion, Facultad de Ciencias, Universidad Autonoma de Madrid, 28049 Madrid, Spain. FAU - Reglero, Guillermo AU - Reglero G AD - Departamento de Produccion y Caracterizacion de Nuevos Alimentos, Instituto de Investigacion en Ciencias de la Alimentacion (CIAL) (CSIC-UAM), 28049 Madrid, Spain; Seccion Departamental de Ciencias de la Alimentacion, Facultad de Ciencias, Universidad Autonoma de Madrid, 28049 Madrid, Spain. FAU - Martin, Diana AU - Martin D AD - Departamento de Produccion y Caracterizacion de Nuevos Alimentos, Instituto de Investigacion en Ciencias de la Alimentacion (CIAL) (CSIC-UAM), 28049 Madrid, Spain; Seccion Departamental de Ciencias de la Alimentacion, Facultad de Ciencias, Universidad Autonoma de Madrid, 28049 Madrid, Spain. Electronic address: diana.martin@uam.es. LA - eng PT - Journal Article DEP - 20191025 PL - England TA - Food Chem JT - Food chemistry JID - 7702639 RN - 0 (Antioxidants) RN - 0 (Enzyme Inhibitors) RN - EC 3.1.1.3 (Lipase) SB - IM MH - Animals MH - Antioxidants/*chemistry/isolation & purification MH - Edible Insects/chemistry MH - Enzyme Inhibitors/*chemistry/isolation & purification MH - Gryllidae/*chemistry MH - Lipase/*antagonists & inhibitors/chemistry MH - Tenebrio/*chemistry OTO - NOTNLM OT - Acheta dometicus OT - Antioxidant OT - Bioactive compounds OT - Edible insects OT - Pancreatic lipase OT - Pressurized-liquid extraction OT - Tenebrio molitor OT - Ultrasound-assisted extraction EDAT- 2019/11/11 06:00 MHDA- 2020/02/23 06:00 CRDT- 2019/11/10 06:00 PHST- 2019/06/19 00:00 [received] PHST- 2019/10/17 00:00 [revised] PHST- 2019/10/17 00:00 [accepted] PHST- 2019/11/11 06:00 [pubmed] PHST- 2020/02/23 06:00 [medline] PHST- 2019/11/10 06:00 [entrez] AID - S0308-8146(19)31873-4 [pii] AID - 10.1016/j.foodchem.2019.125742 [doi] PST - ppublish SO - Food Chem. 2020 Mar 30;309:125742. doi: 10.1016/j.foodchem.2019.125742. Epub 2019 Oct 25.