PMID- 31705832
OWN - NLM
STAT- MEDLINE
DCOM- 20210104
LR  - 20210104
IS  - 2211-5463 (Electronic)
IS  - 2211-5463 (Linking)
VI  - 10
IP  - 1
DP  - 2020 Jan
TI  - Antibodies against nephronectin ameliorate anti-type II collagen-induced 
      arthritis in mice.
PG  - 107-117
LID - 10.1002/2211-5463.12758 [doi]
AB  - The extracellular matrix protein nephronectin (Npnt) is known to be critical for 
      kidney development, but its function in inflammatory diseases is unknown. Here, 
      we developed a new enzyme-linked immunosorbent assay system to detect Npnt in 
      various autoimmune diseases, which revealed that plasma Npnt levels are increased 
      in various mouse autoimmune models. We also report that antibodies against the 
      alpha8beta1 integrin-binding region of Npnt protect mice from anti-type II 
      collagen-induced arthritis, suggesting that Npnt may be a potential therapeutic 
      target molecule for the prevention of autoimmune arthritis.
CI  - (c) 2019 The Authors. Published by FEBS Press and John Wiley & Sons Ltd.
FAU - Kon, Shigeyuki
AU  - Kon S
AUID- ORCID: 0000-0001-5410-8429
AD  - Department of Molecular Immunology, Faculty of Pharmaceutical Sciences, Fukuyama 
      University, Japan.
FAU - Honda, Machiko
AU  - Honda M
AD  - Department of Molecular Immunology, Faculty of Pharmaceutical Sciences, Fukuyama 
      University, Japan.
FAU - Ishikawa, Kiyoshi
AU  - Ishikawa K
AD  - Immuno-Biological Laboratories, Fujioka, Japan.
FAU - Maeda, Masahiro
AU  - Maeda M
AD  - Immuno-Biological Laboratories, Fujioka, Japan.
FAU - Segawa, Tatsuya
AU  - Segawa T
AD  - Immuno-Biological Laboratories, Fujioka, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20191124
PL  - England
TA  - FEBS Open Bio
JT  - FEBS open bio
JID - 101580716
RN  - 0 (Antibodies)
RN  - 0 (Collagen Type II)
RN  - 0 (Extracellular Matrix Proteins)
RN  - 0 (nephronectin)
SB  - IM
MH  - Animals
MH  - Antibodies/*immunology/*therapeutic use
MH  - Arthritis, Experimental/*drug therapy/*immunology/metabolism
MH  - Cells, Cultured
MH  - Collagen Type II/*immunology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Extracellular Matrix Proteins/*antagonists & inhibitors/*immunology/metabolism
MH  - Humans
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C57BL
MH  - NIH 3T3 Cells
MH  - Rats
MH  - Rats, Sprague-Dawley
PMC - PMC6943231
OTO - NOTNLM
OT  - ELISA
OT  - anti-type II collagen-induced arthritis
OT  - antibody
OT  - autoimmune diseases
OT  - nephronectin
COIS- SK and MH declare no conflicts of interest associated with this manuscript. KI, 
      MM, and TS are employees of the Immuno-Biological Laboratories Co., Ltd.
EDAT- 2019/11/11 06:00
MHDA- 2021/01/05 06:00
PMCR- 2019/11/24
CRDT- 2019/11/10 06:00
PHST- 2019/08/27 00:00 [received]
PHST- 2019/10/25 00:00 [revised]
PHST- 2019/11/07 00:00 [accepted]
PHST- 2019/11/11 06:00 [pubmed]
PHST- 2021/01/05 06:00 [medline]
PHST- 2019/11/10 06:00 [entrez]
PHST- 2019/11/24 00:00 [pmc-release]
AID - FEB412758 [pii]
AID - 10.1002/2211-5463.12758 [doi]
PST - ppublish
SO  - FEBS Open Bio. 2020 Jan;10(1):107-117. doi: 10.1002/2211-5463.12758. Epub 2019 
      Nov 24.