PMID- 31706107
OWN - NLM
STAT- MEDLINE
DCOM- 20201016
LR  - 20201016
IS  - 1872-6968 (Electronic)
IS  - 0303-8467 (Linking)
VI  - 187
DP  - 2019 Dec
TI  - Intensity-modulated radiotherapy, coplanar volumetric-modulated arc, therapy, and 
      noncoplanar volumetric-modulated arc therapy in, glioblastoma: A dosimetric 
      comparison.
PG  - 105573
LID - S0303-8467(19)30369-5 [pii]
LID - 10.1016/j.clineuro.2019.105573 [doi]
AB  - OBJECTIVE: Advanced techniques such as volumetric-modulated arc therapy (VMAT) 
      may reduce radiation damage and improve the quality of life for patients.We 
      performed a study comparing dose distributions to the planning target 
      volumes(PTVs) and other organs at risk (OARs) of intensity-modulated radiotherapy 
      (IMRT),coplanar VMAT (coVMAT), and non-coplanar VMAT (ncVMAT). PATIENTS AND 
      METHODS: 13 patients with GBM who had undergone postoperative radiotherapy were 
      enrolled. Three plans for each patient were created, namely, IMRT, coVMAT, and 
      ncVMAT. Prescription doses and normal-tissue constraints were identical for these 
      three plans. The dosimetric differences of target dose distribution, conformity 
      index (CI), homogeneity index (HI), the gradient index (GI), dose of OARs, 
      monitor units (MUs) and beam-on times among these three plans were investigated. 
      RESULTS: These three techniques resulted in comparable maximum, minimum, and mean 
      PTV doses. Small but insignificant differences were observed in GI,CI, and HI. 
      Compared with IMRT, VMAT plans showed statistically significant reductions in the 
      mean doses to the optic chiasm (P < 0.05). Compared with IMRT, VMAT techniques 
      significantly reduced the number of MUs and less beam-on time than IMRT 
      techniques (P ＜ 0.05). However, calculation times were significantly longer for 
      ncVMAT and coVMAT plans at 12 and 12.3 min, versus 2.6 min for IMRT. Our study 
      showed that IMRT or VMAT planning is feasible and efficient for patients with 
      GBM.Compared to IMRT plans, ncVMAT or coVMAT plans showed similar PTV coverage 
      and comparable OARs sparing. VMAT plans significantly reduces the mean doses to 
      the optic chiasm than IMRT plans. CONCLUSION: There was no obvious superiority of 
      ncVMAT over coVMAT in target coverage and sparing of OARs.Compared with IMRT, 
      VMAT techniques significantly reduced the number of MUs and beam-on time but 
      extended the calculation times.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Hou, Yong
AU  - Hou Y
AD  - Department of Radiotherapy, The First Affiliated Hospital of Shandong First 
      Medical University, Jinan, Shandong, 250014, PR China.
FAU - Zhang, Yan
AU  - Zhang Y
AD  - Department of Radiotherapy, The First Affiliated Hospital of Shandong First 
      Medical University, Jinan, Shandong, 250014, PR China.
FAU - Liu, Zhen
AU  - Liu Z
AD  - Department of Radiotherapy, The First Affiliated Hospital of Shandong First 
      Medical University, Jinan, Shandong, 250014, PR China.
FAU - Yv, Lili
AU  - Yv L
AD  - Department of Radiotherapy, The First Affiliated Hospital of Shandong First 
      Medical University, Jinan, Shandong, 250014, PR China.
FAU - Liu, Kun
AU  - Liu K
AD  - Department of Radiotherapy, The First Affiliated Hospital of Shandong First 
      Medical University, Jinan, Shandong, 250014, PR China.
FAU - Tian, Xiufang
AU  - Tian X
AD  - Department of Radiotherapy, The First Affiliated Hospital of Shandong First 
      Medical University, Jinan, Shandong, 250014, PR China.
FAU - Lv, Yajuan
AU  - Lv Y
AD  - Department of Radiotherapy, The First Affiliated Hospital of Shandong First 
      Medical University, Jinan, Shandong, 250014, PR China. Electronic address: 
      xiaochong9696@163.com.
LA  - eng
PT  - Journal Article
DEP - 20191101
PL  - Netherlands
TA  - Clin Neurol Neurosurg
JT  - Clinical neurology and neurosurgery
JID - 7502039
SB  - IM
MH  - Adult
MH  - Aged
MH  - Brain Neoplasms/*radiotherapy/surgery
MH  - Dose-Response Relationship, Radiation
MH  - Female
MH  - Glioblastoma/*radiotherapy/surgery
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Optic Chiasm
MH  - Patient Care Planning
MH  - Postoperative Period
MH  - Prescriptions
MH  - Radiation Dosage
MH  - Radiotherapy Planning, Computer-Assisted
MH  - Radiotherapy, Intensity-Modulated/*methods
OTO - NOTNLM
OT  - Dosimetry
OT  - Glioblastoma
OT  - IMRT
OT  - Noncoplanar
OT  - VMAT
EDAT- 2019/11/11 06:00
MHDA- 2020/10/21 06:00
CRDT- 2019/11/10 06:00
PHST- 2019/08/13 00:00 [received]
PHST- 2019/10/16 00:00 [revised]
PHST- 2019/10/26 00:00 [accepted]
PHST- 2019/11/11 06:00 [pubmed]
PHST- 2020/10/21 06:00 [medline]
PHST- 2019/11/10 06:00 [entrez]
AID - S0303-8467(19)30369-5 [pii]
AID - 10.1016/j.clineuro.2019.105573 [doi]
PST - ppublish
SO  - Clin Neurol Neurosurg. 2019 Dec;187:105573. doi: 10.1016/j.clineuro.2019.105573. 
      Epub 2019 Nov 1.