PMID- 31706829
OWN - NLM
STAT- MEDLINE
DCOM- 20210728
LR  - 20210728
IS  - 1879-4076 (Electronic)
IS  - 1879-4068 (Linking)
VI  - 11
IP  - 4
DP  - 2020 May
TI  - Development of a predictor of one-year mortality in older patients with cancer by 
      geriatric and oncologic parameters.
PG  - 610-616
LID - S1879-4068(19)30141-9 [pii]
LID - 10.1016/j.jgo.2019.10.018 [doi]
AB  - OBJECTIVES: More than 60% of the new cancer diagnoses are currently made in older 
      adults, a highly heterogeneous population. Reliable and time-saving tools to 
      define older adults' prognosis are needed to inform the oncologist's decisions in 
      routine clinical practice. We sought to define a multi-domain classification tool 
      for the prediction of all-cause one-year mortality in a cohort of older adults 
      with solid tumors. MATERIALS AND METHODS: We conducted a single-centre, 
      prospective study of patients with solid cancer aged 65 or older and with G8 
      score </= 14. All patients underwent a comprehensive geriatric assessment (CGA) 
      before starting their surgical or medical treatment. One-year mortality was 
      recorded. A CGA-based prediction tool of one-year mortality was developed and 
      subsequently validated in two independent training and testing cohorts with a 
      70/30 split, respectively. RESULTS: 162 patients were enrolled. Mean patient age 
      was 78 +/- 5.5 years. Forty-three percent of the patients were men. Colorectal and 
      breast cancer were the most common diagnoses. The clinical variables selected for 
      the development of the new classifier (MetaGENUA(R)) were: mini-nutritional 
      assessment (MNA), instrumental day life activities (IADL), Cumulative Illness 
      Rating Scale (CIRS), geriatric depression scale (GDS), age, and cancer stage. In 
      our independent validation cohort, MetaGENUA(R) showed high specificity (0.86) and 
      AUC = 0.71 (95% CI = 0.55-0.87). CONCLUSIONS: MetaGENUA(R) predicts one-year 
      mortality in older patients with cancer with high specificity. As such, 
      MetaGENUA(R) is predicted to reveal as a useful tool to guide the oncologist's 
      decisions in clinical practice.
CI  - Copyright (c) 2019. Published by Elsevier Ltd.
FAU - Giannotti, Chiara
AU  - Giannotti C
AD  - Department of Internal Medicine and Medical Specialties (DiMI), University of 
      Genoa, Italy; IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
FAU - Zoppoli, Gabriele
AU  - Zoppoli G
AD  - Department of Internal Medicine and Medical Specialties (DiMI), University of 
      Genoa, Italy; IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
FAU - Ferrando, Lorenzo
AU  - Ferrando L
AD  - Department of Internal Medicine and Medical Specialties (DiMI), University of 
      Genoa, Italy; Memorial Sloan Kettering Cancer Center, New York, USA.
FAU - Murialdo, Roberto
AU  - Murialdo R
AD  - IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
FAU - Caffa, Irene
AU  - Caffa I
AD  - Department of Internal Medicine and Medical Specialties (DiMI), University of 
      Genoa, Italy.
FAU - Laudisio, Alice
AU  - Laudisio A
AD  - Internal Medicine and Geriatrics Unit, Campus Bio-Medico University, Rome, Italy.
FAU - Scabini, Stefano
AU  - Scabini S
AD  - IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
FAU - Romairone, Emanuele
AU  - Romairone E
AD  - IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
FAU - Fregatti, Piero
AU  - Fregatti P
AD  - Department of Internal Medicine and Medical Specialties (DiMI), University of 
      Genoa, Italy; IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
FAU - Friedman, Daniele
AU  - Friedman D
AD  - Department of Internal Medicine and Medical Specialties (DiMI), University of 
      Genoa, Italy; IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
FAU - Odetti, Patrizio
AU  - Odetti P
AD  - Department of Internal Medicine and Medical Specialties (DiMI), University of 
      Genoa, Italy; IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
FAU - Nencioni, Alessio
AU  - Nencioni A
AD  - Department of Internal Medicine and Medical Specialties (DiMI), University of 
      Genoa, Italy; IRCCS Ospedale Policlinico San Martino, Genoa, Italy. Electronic 
      address: alessio.nencioni@unige.it.
FAU - Ballestrero, Alberto
AU  - Ballestrero A
AD  - Department of Internal Medicine and Medical Specialties (DiMI), University of 
      Genoa, Italy; IRCCS Ospedale Policlinico San Martino, Genoa, Italy. Electronic 
      address: aballestrero@unige.it.
FAU - Monacelli, Fiammetta
AU  - Monacelli F
AD  - Department of Internal Medicine and Medical Specialties (DiMI), University of 
      Genoa, Italy; IRCCS Ospedale Policlinico San Martino, Genoa, Italy. Electronic 
      address: fiammetta.monacelli@unige.it.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20191106
PL  - Netherlands
TA  - J Geriatr Oncol
JT  - Journal of geriatric oncology
JID - 101534770
SB  - IM
MH  - Aged
MH  - *Breast Neoplasms
MH  - *Geriatric Assessment
MH  - Humans
MH  - Male
MH  - Medical Oncology
MH  - Prognosis
MH  - Prospective Studies
OTO - NOTNLM
OT  - Breast cancer
OT  - Colorectal cancer
OT  - Comprehensive geriatric assessment
OT  - Prognostic tools
OT  - Senior patients
OT  - Survival
COIS- Declaration of Competing Interest CG, GZ, LF, AN, PO, AB, and FM are inventors on 
      a patent of a predictor of one-year mortality in older adults with cancer 
      (MetaGENUA(R)) that was filed by the University of Genoa.
EDAT- 2019/11/11 06:00
MHDA- 2021/07/29 06:00
CRDT- 2019/11/11 06:00
PHST- 2019/04/12 00:00 [received]
PHST- 2019/08/07 00:00 [revised]
PHST- 2019/10/22 00:00 [accepted]
PHST- 2019/11/11 06:00 [pubmed]
PHST- 2021/07/29 06:00 [medline]
PHST- 2019/11/11 06:00 [entrez]
AID - S1879-4068(19)30141-9 [pii]
AID - 10.1016/j.jgo.2019.10.018 [doi]
PST - ppublish
SO  - J Geriatr Oncol. 2020 May;11(4):610-616. doi: 10.1016/j.jgo.2019.10.018. Epub 
      2019 Nov 6.