PMID- 31707225
OWN - NLM
STAT- MEDLINE
DCOM- 20200617
LR  - 20200617
IS  - 1873-4367 (Electronic)
IS  - 0927-7765 (Linking)
VI  - 185
DP  - 2020 Jan 1
TI  - Doxorubicin-doxorubicin conjugate prodrug as drug self-delivery system for 
      intracellular pH-triggered slow release.
PG  - 110608
LID - S0927-7765(19)30752-0 [pii]
LID - 10.1016/j.colsurfb.2019.110608 [doi]
AB  - Drug content and releasing rate are the main determining factors for the drug 
      delivery systems (DDSs). Here, doxorubicin dimer (D-DOXcar) was synthesized as 
      drug-drug conjugate prodrug with high drug content of 86%, via an acid-triggered 
      hydrolysable carbamate linker. The prodrug nanoparticles (D-DOXcar-NP) with 
      different diameters were prepared as drug self-delivery system (DSDS) for 
      intracellular pH-triggered slow release. They showed size- and 
      concentration-dependent pH-triggered slow DOX release. For the D-DOXcar-sNP with 
      smaller diameter, the cumulative release ratio reached 25.6% at pH 5.0 within 
      60 h. The MTT results demonstrated that the proposed DSDS showed similar tumor 
      inhibition regardless of carboxylesterases, and an enhanced anti-tumor efficacy 
      on the HepG2 cells in comparison with the free DOX.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Li, Jiagen
AU  - Li J
AD  - State Key Laboratory of Applied Organic Chemistry, College of Chemistry and 
      Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
FAU - Li, Xinming
AU  - Li X
AD  - State Key Laboratory of Applied Organic Chemistry, College of Chemistry and 
      Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
FAU - Liu, Peng
AU  - Liu P
AD  - State Key Laboratory of Applied Organic Chemistry, College of Chemistry and 
      Chemical Engineering, Lanzhou University, Lanzhou 730000, China. Electronic 
      address: pliu@lzu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20191024
PL  - Netherlands
TA  - Colloids Surf B Biointerfaces
JT  - Colloids and surfaces. B, Biointerfaces
JID - 9315133
RN  - 0 (Delayed-Action Preparations)
RN  - 0 (Prodrugs)
RN  - 80168379AG (Doxorubicin)
SB  - IM
MH  - Cell Survival/drug effects
MH  - Delayed-Action Preparations/administration & dosage/chemistry/pharmacology
MH  - Doxorubicin/*administration & dosage/chemistry/pharmacology
MH  - *Drug Delivery Systems
MH  - *Drug Liberation
MH  - Hep G2 Cells
MH  - Humans
MH  - Hydrodynamics
MH  - Hydrogen-Ion Concentration
MH  - MCF-7 Cells
MH  - Nanoparticles/chemistry
MH  - Prodrugs/*administration & dosage/chemistry/pharmacology
MH  - Proton Magnetic Resonance Spectroscopy
OTO - NOTNLM
OT  - Acid-triggered
OT  - Carbamate linker
OT  - Doxorubicin
OT  - Drug self-delivery system
OT  - Drug-drug conjugate
OT  - Slow drug release
EDAT- 2019/11/11 06:00
MHDA- 2020/06/18 06:00
CRDT- 2019/11/11 06:00
PHST- 2019/07/12 00:00 [received]
PHST- 2019/09/20 00:00 [revised]
PHST- 2019/10/20 00:00 [accepted]
PHST- 2019/11/11 06:00 [pubmed]
PHST- 2020/06/18 06:00 [medline]
PHST- 2019/11/11 06:00 [entrez]
AID - S0927-7765(19)30752-0 [pii]
AID - 10.1016/j.colsurfb.2019.110608 [doi]
PST - ppublish
SO  - Colloids Surf B Biointerfaces. 2020 Jan 1;185:110608. doi: 
      10.1016/j.colsurfb.2019.110608. Epub 2019 Oct 24.