PMID- 31708196
OWN - NLM
STAT- MEDLINE
DCOM- 20200608
LR  - 20200608
IS  - 1879-3231 (Electronic)
IS  - 0093-691X (Linking)
VI  - 142
DP  - 2020 Jan 15
TI  - Oxylipin concentrations in bovine corpora lutea during maternal recognition of 
      pregnancy.
PG  - 384-389
LID - S0093-691X(19)30450-9 [pii]
LID - 10.1016/j.theriogenology.2019.10.003 [doi]
AB  - The objective was to determine the effects of pregnancy status on oxylipin 
      profiles and eicosanoid metabolizing enzymes and in corpora lutea (CL) or 
      endometrial (caruncle; CAR and intercaruncle; IC) tissues. Angus crossed cattle 
      were synchronized with the CO-Synch protocol and artificially inseminated (AI). 
      Sixteen days after AI, cattle were euthanized, and reproductive tracts collected 
      from 6 non-pregnant and 6 pregnant cows. Oxylipin profiles and concentrations of 
      progesterone (P(4)) were obtained from CL tissues. The activity of cytochrome 
      P450 1A (CYP1A) and UDP-glucuronosyltransferase (UGT) enzymes were determined 
      using specific luminogenic substrates. Data were analyzed using the MIXED 
      procedure of SAS, and the model included pregnancy status. Corpora lutea of 
      pregnant cattle contained greater (P < 0.05) concentrations of 9,10-DiHODE, 
      15,16-DiHODE, and 9,10-DiHOME. These oxylipins have been observed to increase 
      cellular proliferation and vasodilation. Activity of CYP1A in the CL and UGT in 
      CAR and IC was not different (P > 0.05) between pregnant and non-pregnant cattle. 
      In the CL, activity of UGT was decreased (P < 0.05) in pregnant vs. non-pregnant 
      cattle. The decrease in CL UGT activity during pregnancy indicates alterations in 
      local hormone metabolism, while no differences in CL weight nor amount of P(4) in 
      CL were different between pregnant and non-pregnant cattle. Moreover, the 
      increase in specific concentrations of oxylipins in the CL may indicate a novel 
      pathway of steroid and eicosanoid metabolism during maternal recognition of 
      pregnancy.
CI  - Copyright (c) 2019 Elsevier Inc. All rights reserved.
FAU - Owen, Megan P T
AU  - Owen MPT
AD  - Department of Animal and Dairy Sciences, Mississippi State University, MS, USA.
FAU - Northrop, Emmalee J
AU  - Northrop EJ
AD  - Department of Animal Sciences, South Dakota State University, SD, USA.
FAU - Rich, Jerica J J
AU  - Rich JJJ
AD  - Department of Animal Sciences, South Dakota State University, SD, USA.
FAU - Perry, George A
AU  - Perry GA
AD  - Department of Animal Sciences, South Dakota State University, SD, USA.
FAU - Messman, Riley D
AU  - Messman RD
AD  - Department of Animal and Dairy Sciences, Mississippi State University, MS, USA.
FAU - Dinh, Thu T N
AU  - Dinh TTN
AD  - Department of Animal and Dairy Sciences, Mississippi State University, MS, USA.
FAU - McCarty, Keelee J
AU  - McCarty KJ
AD  - Department of Animal and Dairy Sciences, Mississippi State University, MS, USA.
FAU - Yang, Jun
AU  - Yang J
AD  - Department of Entomology and Cancer Center, University of California, CA, USA.
FAU - Wan, Debin
AU  - Wan D
AD  - Department of Entomology and Cancer Center, University of California, CA, USA.
FAU - Lemley, Caleb O
AU  - Lemley CO
AD  - Department of Animal and Dairy Sciences, Mississippi State University, MS, USA. 
      Electronic address: clemley@ads.msstate.edu.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20191010
PL  - United States
TA  - Theriogenology
JT  - Theriogenology
JID - 0421510
RN  - 0 (Oxylipins)
SB  - IM
MH  - Animals
MH  - Cattle
MH  - Corpus Luteum/*chemistry/metabolism
MH  - Endometrium/metabolism
MH  - Female
MH  - Insemination, Artificial/veterinary
MH  - Maternal-Fetal Relations
MH  - Oxylipins/*analysis/metabolism
MH  - Pregnancy
MH  - *Pregnancy, Animal/metabolism
OTO - NOTNLM
OT  - Cattle
OT  - Corpus luteum
OT  - Cytochrome P450
OT  - Eicosanoid
OT  - Oxylipin
EDAT- 2019/11/12 06:00
MHDA- 2020/06/09 06:00
CRDT- 2019/11/12 06:00
PHST- 2019/07/19 00:00 [received]
PHST- 2019/10/04 00:00 [revised]
PHST- 2019/10/08 00:00 [accepted]
PHST- 2019/11/12 06:00 [pubmed]
PHST- 2020/06/09 06:00 [medline]
PHST- 2019/11/12 06:00 [entrez]
AID - S0093-691X(19)30450-9 [pii]
AID - 10.1016/j.theriogenology.2019.10.003 [doi]
PST - ppublish
SO  - Theriogenology. 2020 Jan 15;142:384-389. doi: 
      10.1016/j.theriogenology.2019.10.003. Epub 2019 Oct 10.