PMID- 31709540
OWN - NLM
STAT- MEDLINE
DCOM- 20210309
LR  - 20210309
IS  - 1097-4652 (Electronic)
IS  - 0021-9541 (Linking)
VI  - 235
IP  - 6
DP  - 2020 Jun
TI  - Leukemia stem cell immunophenotyping tool for diagnostic, prognosis, and 
      therapeutics.
PG  - 4989-4998
LID - 10.1002/jcp.29394 [doi]
AB  - The existence of cancer stem cells is debatable in numerous solid tumors, yet in 
      leukemia, there is compelling evidence of this cell population. Leukemic stem 
      cells (LSCs) are altered cells in which accumulating genetic and/or epigenetic 
      alterations occur, resulting in the transition between the normal, preleukemic, 
      and leukemic status. These cells do not follow the normal differentiation 
      program; they are arrested in a primitive state but with high proliferation 
      potential, generating undifferentiated blast accumulation and a lack of a mature 
      cell population. The identification of LSCs might guide stem cell biology 
      research and provide key points of distinction between these cells and their 
      normal counterparts. The identification and characterization of the main features 
      of LSCs can be useful as tools for diagnosis and treatment. In this context, the 
      aim of the present review was to connect immunophenotype data in the main types 
      of leukemia to further guide technical improvements.
CI  - (c) 2019 Wiley Periodicals, Inc.
FAU - Mastelaro de Rezende, Marina
AU  - Mastelaro de Rezende M
AUID- ORCID: 0000-0002-8934-2108
AD  - Departamento de Bioquimica, Universidade Federal de Sao Paulo (UNIFESP), Sao 
      Paulo, Brazil.
FAU - Ferreira, Alice T
AU  - Ferreira AT
AD  - Departamento de Biofisica, Universidade Federal de Sao Paulo (UNIFESP), Sao 
      Paulo, Brazil.
FAU - Paredes-Gamero, Edgar J
AU  - Paredes-Gamero EJ
AD  - Departamento de Bioquimica, Universidade Federal de Sao Paulo (UNIFESP), Sao 
      Paulo, Brazil.
AD  - Division - Faculdade de Ciencias Farmaceuticas, Alimentos e Nutricao, 
      Universidade Federal do Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, 
      Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20191110
PL  - United States
TA  - J Cell Physiol
JT  - Journal of cellular physiology
JID - 0050222
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - Biomarkers, Tumor/immunology/therapeutic use
MH  - Cell Differentiation/immunology
MH  - Flow Cytometry
MH  - Humans
MH  - Immunophenotyping/*trends
MH  - Leukemia/*diagnosis/*immunology/pathology/therapy
MH  - Neoplastic Stem Cells/*immunology/pathology
MH  - Prognosis
OTO - NOTNLM
OT  - cytometry
OT  - immunophenotype
OT  - leukemia
OT  - leukemic stem cell
OT  - surface markers
EDAT- 2019/11/12 06:00
MHDA- 2021/03/10 06:00
CRDT- 2019/11/12 06:00
PHST- 2019/07/07 00:00 [received]
PHST- 2019/10/25 00:00 [accepted]
PHST- 2019/11/12 06:00 [pubmed]
PHST- 2021/03/10 06:00 [medline]
PHST- 2019/11/12 06:00 [entrez]
AID - 10.1002/jcp.29394 [doi]
PST - ppublish
SO  - J Cell Physiol. 2020 Jun;235(6):4989-4998. doi: 10.1002/jcp.29394. Epub 2019 Nov 
      10.