PMID- 31709762
OWN - NLM
STAT- MEDLINE
DCOM- 20200619
LR  - 20200619
IS  - 1616-5195 (Electronic)
IS  - 1616-5187 (Linking)
VI  - 19
IP  - 12
DP  - 2019 Dec
TI  - Modulation of Foreign Body Reaction against PDMS Implant by Grafting 
      Topographically Different Poly(acrylic acid) Micropatterns.
PG  - e1900206
LID - 10.1002/mabi.201900206 [doi]
AB  - The surface of poly(dimethylsiloxane) (PDMS) is grafted with poly(acrylic acid) 
      (PAA) layers via surface-initiated photopolymerization to suppress the capsular 
      contracture resulting from a foreign body reaction. Owing to the nature of 
      photo-induced polymerization, various PAA micropatterns can be fabricated using 
      photolithography. Hole and stripe micropatterns  approximately 100-microm wide and 3-microm thick are 
      grafted onto the PDMS surface without delamination. The incorporation of PAA 
      micropatterns provides not only chemical cues by hydrophilic PAA microdomains but 
      also topographical cues by hole or stripe micropatterns. In vitro studies reveal 
      that a PAA-grafted PDMS surface has a lower proliferation of both macrophages 
      (Raw 264.7) and fibroblasts (NIH 3T3) regardless of the pattern presence. 
      However, PDMS with PAA micropatterns, especially stripe micropatterns, minimizes 
      the aggregation of fibroblasts and their subsequent differentiation into 
      myofibroblasts. An in vivo study also shows that PDMS samples with stripe 
      micropatterns polarized macrophages into anti-inflammatory M2 macrophages and 
      most effectively inhibits capsular contracture, which is demonstrated by 
      investigation of inflammation score, transforming-growth-factor-beta expression, 
      number of macrophages, and myofibroblasts as well as the collagen density and 
      capsule thickness.
CI  - (c) 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
FAU - Lee, Jae Sang
AU  - Lee JS
AD  - Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul, 
      03722, Republic of Korea.
FAU - Shin, Byung Ho
AU  - Shin BH
AD  - Department of Biomedical Engineering, College of Medicine, Seoul National 
      University, Seoul, 03080, Republic of Korea.
FAU - Yoo, Byoung Yong
AU  - Yoo BY
AD  - Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul, 
      03722, Republic of Korea.
FAU - Nam, Sun-Young
AU  - Nam SY
AD  - Department of Plastic and Reconstructive Surgery, Seoul National University 
      Bundang Hospital, Seongnam, 13620, Republic of Korea.
FAU - Lee, Miji
AU  - Lee M
AD  - Department of Plastic and Reconstructive Surgery, Seoul National University 
      Bundang Hospital, Seongnam, 13620, Republic of Korea.
FAU - Choi, Juhwan
AU  - Choi J
AD  - Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul, 
      03722, Republic of Korea.
FAU - Park, Hansoo
AU  - Park H
AD  - School of Integrative Engineering, Chung-Ang University, Seoul, 06974, Republic 
      of Korea.
FAU - Choy, Young Bin
AU  - Choy YB
AD  - Department of Biomedical Engineering, College of Medicine, Seoul National 
      University, Seoul, 03080, Republic of Korea.
AD  - Interdisciplinary Program for Bioengineering, College of Engineering, Seoul 
      National University, Seoul, 08826, Republic of Korea.
AD  - Institute of Medical & Biological Engineering, Medical Research Center, Seoul 
      National University, Seoul, 03080, Republic of Korea.
FAU - Heo, Chan Yeong
AU  - Heo CY
AD  - Department of Biomedical Engineering, College of Medicine, Seoul National 
      University, Seoul, 03080, Republic of Korea.
AD  - Department of Plastic and Reconstructive Surgery, Seoul National University 
      Bundang Hospital, Seongnam, 13620, Republic of Korea.
AD  - Department of Plastic and Reconstructive Surgery, College of Medicine, Seoul 
      National University, Seoul, 03080, Republic of Korea.
FAU - Koh, Won-Gun
AU  - Koh WG
AUID- ORCID: 0000-0002-5191-2531
AD  - Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul, 
      03722, Republic of Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20191110
PL  - Germany
TA  - Macromol Biosci
JT  - Macromolecular bioscience
JID - 101135941
RN  - 0 (Acrylic Resins)
RN  - 0 (Biomarkers)
RN  - 0 (Dimethylpolysiloxanes)
RN  - 0 (Transforming Growth Factor beta)
RN  - 4Q93RCW27E (carbopol 940)
RN  - 63148-62-9 (baysilon)
SB  - IM
MH  - Acrylic Resins/chemistry/*pharmacology
MH  - Animals
MH  - Biomarkers/metabolism
MH  - Cell Adhesion/drug effects
MH  - Cell Differentiation/drug effects
MH  - Cell Proliferation/drug effects
MH  - Dimethylpolysiloxanes/chemistry/*pharmacology
MH  - Foreign-Body Reaction/chemically induced/*immunology
MH  - Gene Expression/drug effects
MH  - Hydrophobic and Hydrophilic Interactions
MH  - *Implants, Experimental
MH  - Male
MH  - Mice
MH  - NIH 3T3 Cells
MH  - RAW 264.7 Cells
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Skin/*drug effects/immunology/metabolism
MH  - Subcutaneous Tissue/*drug effects/immunology/metabolism
MH  - Surface Properties
MH  - Transforming Growth Factor beta/genetics/immunology
OTO - NOTNLM
OT  - capsular contracture
OT  - foreign body reaction
OT  - micropatterns
OT  - photo-induced grafting
OT  - poly(acrylic acid) layer
EDAT- 2019/11/12 06:00
MHDA- 2020/06/20 06:00
CRDT- 2019/11/12 06:00
PHST- 2019/06/11 00:00 [received]
PHST- 2019/09/15 00:00 [revised]
PHST- 2019/11/12 06:00 [pubmed]
PHST- 2020/06/20 06:00 [medline]
PHST- 2019/11/12 06:00 [entrez]
AID - 10.1002/mabi.201900206 [doi]
PST - ppublish
SO  - Macromol Biosci. 2019 Dec;19(12):e1900206. doi: 10.1002/mabi.201900206. Epub 2019 
      Nov 10.