PMID- 31712913
OWN - NLM
STAT- MEDLINE
DCOM- 20200824
LR  - 20200824
IS  - 1436-2813 (Electronic)
IS  - 0941-1291 (Linking)
VI  - 50
IP  - 5
DP  - 2020 May
TI  - What is the most useful body composition parameter for predicting toxicities of 
      preoperative chemotherapy for gastric cancer?
PG  - 509-515
LID - 10.1007/s00595-019-01915-5 [doi]
AB  - PURPOSE: Preoperative chemotherapy is an effective treatment option for 
      resectable gastric cancer, but it is associated with various adverse events 
      (AEs). This study aimed to identify the body composition parameters that most 
      accurately predicted the incidence of AEs in preoperative chemotherapy for 
      gastric cancer. METHODS: The present study included a total of 114 patients who 
      received preoperative chemotherapy for resectable gastric cancer. We estimated 
      various body composition parameters using computed tomography images obtained 
      before preoperative chemotherapy. Their associations with the incidence of 
      hematological (grade >/= 3) and non-hematological (grade >/= 2) AEs were analyzed by 
      multivariate logistic regression analyses. RESULTS: Seventy-two of the 114 
      (63.2%) patients experienced hematological AEs (grade >/= 3), specifically 
      neutropenia in 68 (59.6%), anemia in 5 (4.9%), and thrombocytopenia in 3 (2.6%). 
      Meanwhile, 59 patients (51.8%) experienced non-hematological AEs (grade >/= 2), 
      namely hypoalbuminemia in 31 (27.2%), anorexia in 24 (21.1%), and febrile 
      neutropenia in 17 (14.9%). Multivariate analyses revealed that a low psoas muscle 
      index (PMI) was an independent risk factor for the incidence of both 
      hematological and non-hematological AEs. CONCLUSIONS: Patients with a low PMI 
      experienced an increased incidence of hematological and non-hematological 
      toxicities during preoperative chemotherapy for gastric cancer. Clinicians should 
      be aware of these risks in this population.
FAU - Hashimoto, Tadayoshi
AU  - Hashimoto T
AD  - Department of Gastroenterological Surgery, Osaka University Graduate School of 
      Medicine, 2-2-E2, Yamadaoka, Suita, Osaka, 565-0871, Japan.
FAU - Kurokawa, Yukinori
AU  - Kurokawa Y
AD  - Department of Gastroenterological Surgery, Osaka University Graduate School of 
      Medicine, 2-2-E2, Yamadaoka, Suita, Osaka, 565-0871, Japan. 
      ykurokawa@gesurg.med.osaka-u.ac.jp.
FAU - Takahashi, Tsuyoshi
AU  - Takahashi T
AD  - Department of Gastroenterological Surgery, Osaka University Graduate School of 
      Medicine, 2-2-E2, Yamadaoka, Suita, Osaka, 565-0871, Japan.
FAU - Saito, Takuro
AU  - Saito T
AD  - Department of Gastroenterological Surgery, Osaka University Graduate School of 
      Medicine, 2-2-E2, Yamadaoka, Suita, Osaka, 565-0871, Japan.
FAU - Yamashita, Kotaro
AU  - Yamashita K
AD  - Department of Gastroenterological Surgery, Osaka University Graduate School of 
      Medicine, 2-2-E2, Yamadaoka, Suita, Osaka, 565-0871, Japan.
FAU - Tanaka, Koji
AU  - Tanaka K
AD  - Department of Gastroenterological Surgery, Osaka University Graduate School of 
      Medicine, 2-2-E2, Yamadaoka, Suita, Osaka, 565-0871, Japan.
FAU - Makino, Tomoki
AU  - Makino T
AD  - Department of Gastroenterological Surgery, Osaka University Graduate School of 
      Medicine, 2-2-E2, Yamadaoka, Suita, Osaka, 565-0871, Japan.
FAU - Yamasaki, Makoto
AU  - Yamasaki M
AD  - Department of Gastroenterological Surgery, Osaka University Graduate School of 
      Medicine, 2-2-E2, Yamadaoka, Suita, Osaka, 565-0871, Japan.
FAU - Motoori, Masaaki
AU  - Motoori M
AD  - Department of Gastroenterological Surgery, Osaka University Graduate School of 
      Medicine, 2-2-E2, Yamadaoka, Suita, Osaka, 565-0871, Japan.
AD  - Department of Surgery, Osaka General Medical Center, Osaka, Japan.
FAU - Kimura, Yutaka
AU  - Kimura Y
AD  - Department of Gastroenterological Surgery, Osaka University Graduate School of 
      Medicine, 2-2-E2, Yamadaoka, Suita, Osaka, 565-0871, Japan.
AD  - Department of Surgery, Faculty of Medicine, Kindai University, Osaka, Japan.
FAU - Nakajima, Kiyokazu
AU  - Nakajima K
AD  - Department of Gastroenterological Surgery, Osaka University Graduate School of 
      Medicine, 2-2-E2, Yamadaoka, Suita, Osaka, 565-0871, Japan.
FAU - Mori, Masaki
AU  - Mori M
AD  - Department of Surgery and Science, Kyushu University Graduate School of Medical 
      Sciences, Fukuoka, Japan.
FAU - Doki, Yuichiro
AU  - Doki Y
AD  - Department of Gastroenterological Surgery, Osaka University Graduate School of 
      Medicine, 2-2-E2, Yamadaoka, Suita, Osaka, 565-0871, Japan.
LA  - eng
PT  - Journal Article
DEP - 20191111
PL  - Japan
TA  - Surg Today
JT  - Surgery today
JID - 9204360
RN  - 0 (Antineoplastic Agents)
SB  - IM
MH  - Anemia/chemically induced/epidemiology
MH  - Anorexia/chemically induced/epidemiology
MH  - Antineoplastic Agents/*adverse effects/toxicity
MH  - *Body Composition
MH  - Febrile Neutropenia/chemically induced/epidemiology
MH  - Humans
MH  - Hypoalbuminemia/chemically induced/epidemiology
MH  - *Preoperative Care
MH  - Psoas Muscles/pathology
MH  - Risk Factors
MH  - Stomach Neoplasms/*drug therapy/*surgery
MH  - Thrombocytopenia/chemically induced/epidemiology
OTO - NOTNLM
OT  - Body composition parameters
OT  - Chemotherapeutic toxicity
OT  - Gastric cancer
OT  - Preoperative chemotherapy
OT  - Psoas muscle index
EDAT- 2019/11/13 06:00
MHDA- 2020/08/25 06:00
CRDT- 2019/11/13 06:00
PHST- 2019/07/22 00:00 [received]
PHST- 2019/10/26 00:00 [accepted]
PHST- 2019/11/13 06:00 [pubmed]
PHST- 2020/08/25 06:00 [medline]
PHST- 2019/11/13 06:00 [entrez]
AID - 10.1007/s00595-019-01915-5 [pii]
AID - 10.1007/s00595-019-01915-5 [doi]
PST - ppublish
SO  - Surg Today. 2020 May;50(5):509-515. doi: 10.1007/s00595-019-01915-5. Epub 2019 
      Nov 11.