PMID- 31713534
OWN - NLM
STAT- MEDLINE
DCOM- 20200323
LR  - 20221207
IS  - 1643-3750 (Electronic)
IS  - 1234-1010 (Print)
IS  - 1234-1010 (Linking)
VI  - 25
DP  - 2019 Nov 12
TI  - The Association of UNC13B Gene Polymorphisms and Diabetic Kidney Disease in a 
      Chinese Han Population.
PG  - 8527-8533
LID - 10.12659/MSM.919930 [doi]
AB  - BACKGROUND Polymorphisms in the UNC13B gene are associated with diabetic kidney 
      disease (DKD) in the European population. Asian populations are more likely to 
      suffer from complications of type 2 diabetes mellitus (T2DM), including diabetic 
      kidney disease (DKD). This case-control study aimed to investigate the 
      association between UNC13B gene polymorphisms and DKD in a Chinese Han 
      population. MATERIAL AND METHODS Five single nucleotide polymorphism (SNP) loci 
      (rs13293564, rs17360668, rs10114937, rs661712, and rs2281999) were genotyped in 
      the UNC13B gene in 600 Chinese Han subjects. The study population included 
      patients with T2DM with DKD (N=292) and control patients with T2DM without DKD 
      (N=308). SNP genotyping was performed using a Sequenom MassARRAY system using 
      chip-based matrix-assisted laser desorption ionization-time of flight mass 
      spectrometry (MALDI-TOF MS). RESULTS There were no significant differences in the 
      distribution of allele or genotype frequencies in the five UNC13B SNP markers 
      (rs13293564, rs17360668, rs10114937, rs661712, and rs2281999) between the DKD 
      group and control group of patients with T2DM. Haplotype analysis identified 
      eight haplotypes for the combined effect of the five SNP markers in the UNC13B 
      gene. The haplotype GGCCG was significantly associated with an increased risk of 
      DKD. CONCLUSIONS This was the first study to demonstrate an association between 
      UNC13B gene polymorphisms and the susceptibility to DKD in a Chinese Han 
      population with T2DM. The haplotype GGCCG was significantly associated with an 
      increased risk of DKD. The findings highlight the joint effect of SNP markers in 
      the pathogenesis of DKD.
FAU - Wang, Ya
AU  - Wang Y
AD  - Department of Endocrinology, Jingzhou First People's Hospital, The First 
      Affiliated Hospital of Yangtze University, Jingzhou, Hubei, China (mainland).
FAU - Tan, Jie
AU  - Tan J
AD  - Department of Hematology, Jingzhou First People's Hospital, The First Affiliated 
      Hospital of Yangtze University, Jingzhou, Hubei, China (mainland).
FAU - Liu, Dan
AU  - Liu D
AD  - Department of Endocrinology, Jingzhou First People's Hospital, The First 
      Affiliated Hospital of Yangtze University, Jingzhou, Hubei, China (mainland).
FAU - Yang, Yameng
AU  - Yang Y
AD  - Department of Rheumatism and Immunology, Jingzhou First People's Hospital, The 
      First Affiliated Hospital of Yangtze University, Jingzhou, Hubei, China 
      (mainland).
FAU - Wu, Hongyan
AU  - Wu H
AD  - Department of Endocrinology, Jingzhou First People's Hospital, The First 
      Affiliated Hospital of Yangtze University, Jingzhou, Hubei, China (mainland).
LA  - eng
PT  - Journal Article
DEP - 20191112
PL  - United States
TA  - Med Sci Monit
JT  - Medical science monitor : international medical journal of experimental and 
      clinical research
JID - 9609063
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (UNC13B protein, human)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Asian People/genetics
MH  - Case-Control Studies
MH  - China
MH  - Diabetes Mellitus, Type 2/genetics
MH  - Diabetic Nephropathies/*genetics
MH  - Ethnicity/genetics
MH  - Female
MH  - Gene Frequency/genetics
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Haplotypes/genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nerve Tissue Proteins/*genetics/metabolism
MH  - Polymorphism, Single Nucleotide/genetics
PMC - PMC6865244
EDAT- 2019/11/13 06:00
MHDA- 2020/03/24 06:00
PMCR- 2019/11/12
CRDT- 2019/11/13 06:00
PHST- 2019/11/13 06:00 [entrez]
PHST- 2019/11/13 06:00 [pubmed]
PHST- 2020/03/24 06:00 [medline]
PHST- 2019/11/12 00:00 [pmc-release]
AID - 919930 [pii]
AID - 10.12659/MSM.919930 [doi]
PST - epublish
SO  - Med Sci Monit. 2019 Nov 12;25:8527-8533. doi: 10.12659/MSM.919930.