PMID- 31713632
OWN - NLM
STAT- MEDLINE
DCOM- 20210625
LR  - 20210625
IS  - 1532-2092 (Electronic)
IS  - 1099-5129 (Linking)
VI  - 22
IP  - 1
DP  - 2020 Jan 1
TI  - Biventricular pacing during cardiac magnetic resonance imaging.
PG  - 117-124
LID - 10.1093/europace/euz289 [doi]
AB  - AIMS: We aimed to assess the effect of cardiac resynchronization on left 
      ventricular (LV) function, volumes, geometry, and mechanics in order to 
      demonstrate reverse remodelling using cardiac magnetic resonance (CMR) with 
      resynchronization on. METHODS AND RESULTS: New York Heart Association (NYHA) 
      Class II-III patients on optimal medical therapy with LV ejection fraction (LVEF) 
      </=35%, and complete LBBB with broad QRS (>150 ms) were prospectively recruited. 
      Cardiac magnetic resonance examination was performed at baseline and at 6-month 
      follow-up, applying both biventricular and AOO pacing. The following data were 
      measured: conventional CMR parameters, remodelling indices, global longitudinal, 
      circumferential, radial strain, global dyssynchrony [mechanical dispersion (MD) 
      defined as the standard deviation of time to peak longitudinal/circumferential 
      strain in 16 LV segments], and regional dyssynchrony (maximum differences in time 
      between peak septal and lateral transversal displacement). Thirteen patients 
      (64 +/- 7 years, 38% male) were enrolled. Comparing the baseline and follow-up CMR 
      parameters measured during biventricular pacing, significant increase in LVEF, 
      and decrease in LV end-diastolic volume index (LVEDVi) and LV end-systolic volume 
      index (LVESVi) were found. Left ventricular remodelling indices, global 
      longitudinal, circumferential, and radial strain values showed significant 
      improvement. Circumferential MD decreased (20.5 +/- 5.5 vs. 13.4 +/- 3.4, P < 0.001), 
      while longitudinal MD did not change. Regional dyssynchrony drastically improved 
      (362 +/- 96 vs. 104 +/- 66 ms, P < 0.001). Applying AOO pacing resulted in an 
      immediate deterioration in LVEF, LVESVi, circumferential strain, global and 
      regional dyssynchrony. CONCLUSION: Cardiac magnetic resonance imaging during 
      biventricular pacing is feasible and enables a more precise quantification of LV 
      function, morphology, and mechanics. As a result, it may contribute to a better 
      understanding of the effects of resynchronization therapy and might improve 
      responder rate in the future.
CI  - (c) The Author(s) 2019. Published by Oxford University Press on behalf of the 
      European Society of Cardiology.
FAU - Vago, Hajnalka
AU  - Vago H
AD  - Heart and Vascular Center, Semmelweis University, Budapest, Hungary.
FAU - Czimbalmos, Csilla
AU  - Czimbalmos C
AD  - Heart and Vascular Center, Semmelweis University, Budapest, Hungary.
FAU - Papp, Roland
AU  - Papp R
AD  - Heart and Vascular Center, Semmelweis University, Budapest, Hungary.
FAU - Szabo, Liliana
AU  - Szabo L
AD  - Heart and Vascular Center, Semmelweis University, Budapest, Hungary.
FAU - Toth, Attila
AU  - Toth A
AD  - Heart and Vascular Center, Semmelweis University, Budapest, Hungary.
FAU - Dohy, Zsofia
AU  - Dohy Z
AD  - Heart and Vascular Center, Semmelweis University, Budapest, Hungary.
FAU - Csecs, Ibolya
AU  - Csecs I
AD  - Heart and Vascular Center, Semmelweis University, Budapest, Hungary.
FAU - Suhai, Ferenc
AU  - Suhai F
AD  - Heart and Vascular Center, Semmelweis University, Budapest, Hungary.
FAU - Kosztin, Annamaria
AU  - Kosztin A
AD  - Heart and Vascular Center, Semmelweis University, Budapest, Hungary.
FAU - Molnar, Levente
AU  - Molnar L
AD  - Heart and Vascular Center, Semmelweis University, Budapest, Hungary.
FAU - Geller, Laszlo
AU  - Geller L
AD  - Heart and Vascular Center, Semmelweis University, Budapest, Hungary.
FAU - Merkely, Bela
AU  - Merkely B
AD  - Heart and Vascular Center, Semmelweis University, Budapest, Hungary.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Europace
JT  - Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal 
      of the working groups on cardiac pacing, arrhythmias, and cardiac cellular 
      electrophysiology of the European Society of Cardiology
JID - 100883649
SB  - IM
MH  - Cardiac Pacing, Artificial
MH  - *Cardiac Resynchronization Therapy
MH  - Female
MH  - *Heart Failure/diagnostic imaging/therapy
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Stroke Volume
MH  - *Ventricular Dysfunction, Left/diagnostic imaging/therapy
MH  - Ventricular Function, Left
OTO - NOTNLM
OT  - Biventricular pacing
OT  - Cardiac magnetic resonance
OT  - Cardiac resynchronization therapy
OT  - Heart failure
EDAT- 2019/11/13 06:00
MHDA- 2021/06/29 06:00
CRDT- 2019/11/13 06:00
PHST- 2019/05/08 00:00 [received]
PHST- 2019/10/03 00:00 [accepted]
PHST- 2019/11/13 06:00 [pubmed]
PHST- 2021/06/29 06:00 [medline]
PHST- 2019/11/13 06:00 [entrez]
AID - 5622734 [pii]
AID - 10.1093/europace/euz289 [doi]
PST - ppublish
SO  - Europace. 2020 Jan 1;22(1):117-124. doi: 10.1093/europace/euz289.