PMID- 31714891
OWN - NLM
STAT- MEDLINE
DCOM- 20200625
LR  - 20210301
IS  - 1619-3997 (Electronic)
IS  - 0300-5577 (Linking)
VI  - 48
IP  - 1
DP  - 2019 Dec 18
TI  - Prolonged ventilation and postnatal growth of preterm infants.
PG  - 82-86
LID - 10.1515/jpm-2019-0278 [doi]
AB  - Background Extremely premature infants often need invasive respiratory support 
      from birth, but have low nutritional reserves and high metabolic demands. Our aim 
      was to determine if there was a relationship between prolonged ventilation and 
      reduced postnatal growth in such infants. Methods A retrospective, observational 
      study was undertaken. Data from infants born at less than 28 weeks of gestational 
      age and ventilated for 7 days or more were collected and analysed including 
      gestational age, gender, birth and discharge weight, birth and discharge head 
      circumference, days of invasive mechanical ventilation and use of postnatal 
      corticosteroids. The duration of invasive mechanical ventilation and the 
      differences in weight (DeltaWz) and head circumference (DeltaHz) z-score from birth to 
      discharge were calculated. Results Fifty-five infants were studied with a median 
      [interquartile range (IQR)] gestational age at birth of 25.3 (24.3-26.7) weeks 
      and birth weight of 0.73 (0.65-0.87) kg. The median duration of mechanical 
      ventilation was 45 (33-68) days. Both DeltaWz and DeltaHz were significantly negatively 
      correlated to the number of invasive mechanical ventilation days (P = 0.01 and 
      P = 0.03, respectively), but not to the use of postnatal corticosteroids. 
      Conclusion Poor postnatal growth is significantly negatively associated with a 
      longer duration of mechanical ventilation in extremely prematurely born infants.
FAU - Williams, Emma
AU  - Williams E
AD  - Department of Women and Children's Health, School of Life Course Sciences, 
      Faculty of Life Sciences and Medicine, King's College London, London, UK.
FAU - Dassios, Theodore
AU  - Dassios T
AD  - Department of Women and Children's Health, School of Life Course Sciences, 
      Faculty of Life Sciences and Medicine, King's College London, London, UK.
AD  - Neonatal Intensive Care Centre, King's College Hospital NHS Foundation Trust, 
      London, UK.
AD  - The Asthma UK Centre for Allergic Mechanisms in Asthma, King's College London, 
      London, UK.
FAU - Arnold, Kate
AU  - Arnold K
AD  - Paediatric Dietetic Department, King's College Hospital NHS Foundation Trust, 
      London, UK.
FAU - Hickey, Ann
AU  - Hickey A
AD  - Neonatal Intensive Care Centre, King's College Hospital NHS Foundation Trust, 
      London, UK.
FAU - Greenough, Anne
AU  - Greenough A
AUID- ORCID: 0000-0002-8672-5349
AD  - Department of Women and Children's Health, School of Life Course Sciences, 
      Faculty of Life Sciences and Medicine, King's College London, London, UK.
AD  - The Asthma UK Centre for Allergic Mechanisms in Asthma, King's College London, 
      London, UK.
AD  - NIHR Biomedical Centre at Guy's and St Thomas NHS Foundation Trust and King's 
      College London, London, UK, Tel.: +0203 3299 3037, Fax: +0203 3299 8284.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - Germany
TA  - J Perinat Med
JT  - Journal of perinatal medicine
JID - 0361031
SB  - IM
MH  - Female
MH  - Humans
MH  - Infant, Extremely Premature/*growth & development
MH  - Infant, Newborn
MH  - Intubation, Intratracheal/*adverse effects
MH  - Male
MH  - Respiration, Artificial/*adverse effects/statistics & numerical data
MH  - Retrospective Studies
OTO - NOTNLM
OT  - growth
OT  - mechanical ventilation
OT  - nutrition
OT  - preterm
EDAT- 2019/11/13 06:00
MHDA- 2020/06/26 06:00
CRDT- 2019/11/13 06:00
PHST- 2019/07/24 00:00 [received]
PHST- 2019/10/10 00:00 [accepted]
PHST- 2019/11/13 06:00 [pubmed]
PHST- 2020/06/26 06:00 [medline]
PHST- 2019/11/13 06:00 [entrez]
AID - jpm-2019-0278 [pii]
AID - 10.1515/jpm-2019-0278 [doi]
PST - ppublish
SO  - J Perinat Med. 2019 Dec 18;48(1):82-86. doi: 10.1515/jpm-2019-0278.