PMID- 31715158
OWN - NLM
STAT- MEDLINE
DCOM- 20200501
LR  - 20210514
IS  - 1879-1891 (Electronic)
IS  - 0002-9394 (Print)
IS  - 0002-9394 (Linking)
VI  - 210
DP  - 2020 Feb
TI  - Comparison of Short- And Long-Term Variability in Standard Perimetry and Spectral 
      Domain Optical Coherence Tomography in Glaucoma.
PG  - 19-25
LID - S0002-9394(19)30539-2 [pii]
LID - 10.1016/j.ajo.2019.10.034 [doi]
AB  - PURPOSE: To assess short- and long-term variability on standard automated 
      perimetry (SAP) and spectral domain optical coherence tomography (SD-OCT) in 
      glaucoma. DESIGN: Prospective cohort. METHODS: Ordinary least squares linear 
      regression of SAP mean deviation (MD) and SD-OCT global retinal nerve fiber layer 
      (RNFL) thickness were fitted over time for sequential tests conducted within 
      5 weeks (short-term testing) and annually (long-term testing). Residuals were 
      obtained by subtracting the predicted and observed values, and each patient's 
      standard deviation (SD) of the residuals was used as a measure of variability. 
      Wilcoxon signed-rank test was performed to test the hypothesis of equality 
      between short- and long-term variability. RESULTS: A total of 43 eyes of 43 
      glaucoma subjects were included. Subjects had a mean 4.5 +/- 0.8 SAP and OCT tests 
      for short-term variability assessment. For long-term variability, the same number 
      of tests were performed and results annually collected over an average of 4.0 +/- 
      0.8 years. The average SD of the residuals was significantly higher in the 
      long-term than in the short-term period for both tests: 1.05 +/- 0.70 dB vs. 0.61 +/- 
      0.34 dB, respectively (P < 0.001) for SAP MD and 1.95 +/- 1.86 mum vs. 0.81 +/- 
      0.56 mum, respectively (P < 0.001) for SD-OCT RNFL thickness. CONCLUSIONS: 
      Long-term variability was higher than short-term variability on SD-OCT and SAP. 
      Because current event-based algorithms for detection of glaucoma progression on 
      SAP and SD-OCT have relied on short-term variability data to establish their 
      normative databases, these algorithms may be underestimating the variability in 
      the long-term and thus may overestimate progression over time.
CI  - Copyright (c) 2019 Elsevier Inc. All rights reserved.
FAU - Urata, Carla N
AU  - Urata CN
AD  - Duke Eye Center, Department of Ophthalmology, Duke University, Durham, North 
      Carolina, USA.
FAU - Mariottoni, Eduardo B
AU  - Mariottoni EB
AD  - Duke Eye Center, Department of Ophthalmology, Duke University, Durham, North 
      Carolina, USA.
FAU - Jammal, Alessandro A
AU  - Jammal AA
AD  - Duke Eye Center, Department of Ophthalmology, Duke University, Durham, North 
      Carolina, USA.
FAU - Ogata, Nara G
AU  - Ogata NG
AD  - Duke Eye Center, Department of Ophthalmology, Duke University, Durham, North 
      Carolina, USA.
FAU - Thompson, Atalie C
AU  - Thompson AC
AD  - Duke Eye Center, Department of Ophthalmology, Duke University, Durham, North 
      Carolina, USA.
FAU - Berchuck, Samuel I
AU  - Berchuck SI
AD  - Duke Eye Center, Department of Ophthalmology, Duke University, Durham, North 
      Carolina, USA; Department of Statistical Science and Forge, Duke University, 
      Durham, North Carolina, USA.
FAU - Estrela, Tais
AU  - Estrela T
AD  - Duke Eye Center, Department of Ophthalmology, Duke University, Durham, North 
      Carolina, USA.
FAU - Medeiros, Felipe A
AU  - Medeiros FA
AD  - Duke Eye Center, Department of Ophthalmology, Duke University, Durham, North 
      Carolina, USA. Electronic address: felipe.medeiros@duke.edu.
LA  - eng
GR  - R01 EY021818/EY/NEI NIH HHS/United States
GR  - R01 EY029885/EY/NEI NIH HHS/United States
GR  - R42 EY027651/EY/NEI NIH HHS/United States
GR  - R43 EY027651/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20191109
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Algorithms
MH  - Disease Progression
MH  - Female
MH  - Glaucoma/*diagnosis
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Tomography, Optical Coherence/*methods/standards
MH  - Visual Field Tests/*methods/standards
PMC - PMC7224685
MID - NIHMS1547088
EDAT- 2019/11/13 06:00
MHDA- 2020/05/02 06:00
PMCR- 2021/02/01
CRDT- 2019/11/13 06:00
PHST- 2019/05/23 00:00 [received]
PHST- 2019/10/22 00:00 [revised]
PHST- 2019/10/24 00:00 [accepted]
PHST- 2019/11/13 06:00 [pubmed]
PHST- 2020/05/02 06:00 [medline]
PHST- 2019/11/13 06:00 [entrez]
PHST- 2021/02/01 00:00 [pmc-release]
AID - S0002-9394(19)30539-2 [pii]
AID - 10.1016/j.ajo.2019.10.034 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2020 Feb;210:19-25. doi: 10.1016/j.ajo.2019.10.034. Epub 2019 
      Nov 9.