PMID- 31715341
OWN - NLM
STAT- MEDLINE
DCOM- 20200505
LR  - 20200505
IS  - 1873-3476 (Electronic)
IS  - 0378-5173 (Linking)
VI  - 572
DP  - 2019 Dec 15
TI  - Metronidazole/Hydroxypropyl-beta-Cyclodextrin inclusion complex nanofibrous webs as 
      fast-dissolving oral drug delivery system.
PG  - 118828
LID - S0378-5173(19)30873-7 [pii]
LID - 10.1016/j.ijpharm.2019.118828 [doi]
AB  - In this study, Metronidazole/Hydroxypropyl-beta-Cyclodextrin (HP-beta-CyD) inclusion 
      complex nanofibrous webs were produced via electrospinning for the purpose of 
      fast-dissolving oral drug delivery. The Metronidazole/HP-beta-CyD inclusion complex 
      aqueous solutions having two different molar ratio of Metronidazole/HP-beta-CyD (1/1 
      and 1/2) were prepared by using very high concentration of HP-beta-CyD (200%, w/v) 
      in order to achieve polymer-free electrospinning of Metronidazole/HP-beta-CyD 
      nanofibers (NF). Metronidazole was totally encapsulated and preserved without any 
      loss during the electrospinning process in which both systems yielded 
      Metronidazole/HP-beta-CyD NF having the same initial molar ratio of 1/1 and 1/2. The 
      electrospinning of both Metronidazole/HP-beta-CyD (1/1 and 1/2) aqueous solutions 
      yielded uniform and bead-less fiber morphology having ~190 nm average fiber 
      diameter. Both Metronidazole/HP-beta-CyD NF (1/1 and 1/2) samples were in the form 
      of nanofibrous webs with free-standing and flexible character. The structural and 
      thermal characterizations of Metronidazole/HP-beta-CyD NF (1/1 and 1/2) proved that 
      Metronidazole was in the inclusion complex state with HP-beta-CyD in these 
      nanofibrous webs. Metronidazole is an antibiotic which is poorly water-soluble 
      drug, but the phase solubility and dissolution tests revealed that the 
      water-solubility of Metronidazole was significantly enhanced by HP-beta-CyD 
      inclusion complexation. In addition, Metronidazole/HP-beta-CyD (1/1 and 1/2) 
      nanofibrous webs have shown very fast-dissolving behavior when placed in water or 
      contacted to artificial saliva suggesting that such Metronidazole/HP-beta-CyD 
      nanofibrous webs can be suitable for fast-dissolving oral drug delivery.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Celebioglu, Asli
AU  - Celebioglu A
AD  - Department of Fiber Science & Apparel Design, College of Human Ecology, Cornell 
      University, Ithaca, NY 14853, United States. Electronic address: 
      ac2873@cornell.edu.
FAU - Uyar, Tamer
AU  - Uyar T
AD  - Department of Fiber Science & Apparel Design, College of Human Ecology, Cornell 
      University, Ithaca, NY 14853, United States. Electronic address: 
      tu46@cornell.edu.
LA  - eng
PT  - Journal Article
DEP - 20191109
PL  - Netherlands
TA  - Int J Pharm
JT  - International journal of pharmaceutics
JID - 7804127
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Drug Carriers)
RN  - 059QF0KO0R (Water)
RN  - 140QMO216E (Metronidazole)
RN  - 1I96OHX6EK (2-Hydroxypropyl-beta-cyclodextrin)
SB  - IM
MH  - 2-Hydroxypropyl-beta-cyclodextrin/*chemistry
MH  - Administration, Oral
MH  - Anti-Bacterial Agents/administration & dosage/chemistry
MH  - Chemistry, Pharmaceutical
MH  - Drug Carriers/chemistry
MH  - *Drug Delivery Systems
MH  - Drug Liberation
MH  - Metronidazole/*administration & dosage/chemistry
MH  - *Nanofibers
MH  - Particle Size
MH  - Saliva/metabolism
MH  - Solubility
MH  - Water/chemistry
OTO - NOTNLM
OT  - Electrospinning
OT  - Fast-dissolving
OT  - Hydroxypropyl-beta-cyclodextrin
OT  - Metronidazole
OT  - Nanofibers
OT  - Oral drug delivery
EDAT- 2019/11/13 06:00
MHDA- 2020/05/06 06:00
CRDT- 2019/11/13 06:00
PHST- 2019/08/14 00:00 [received]
PHST- 2019/10/21 00:00 [revised]
PHST- 2019/10/26 00:00 [accepted]
PHST- 2019/11/13 06:00 [pubmed]
PHST- 2020/05/06 06:00 [medline]
PHST- 2019/11/13 06:00 [entrez]
AID - S0378-5173(19)30873-7 [pii]
AID - 10.1016/j.ijpharm.2019.118828 [doi]
PST - ppublish
SO  - Int J Pharm. 2019 Dec 15;572:118828. doi: 10.1016/j.ijpharm.2019.118828. Epub 
      2019 Nov 9.