PMID- 31717517
OWN - NLM
STAT- MEDLINE
DCOM- 20200403
LR  - 20200403
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 20
IP  - 22
DP  - 2019 Nov 9
TI  - Distinct Subcellular Compartments of Dendritic Cells Used for Cross-Presentation.
LID - 10.3390/ijms20225606 [doi]
LID - 5606
AB  - Dendritic cells (DCs) present exogenous protein-derived peptides on major 
      histocompatibility complex class I molecules to prime naive CD8(+) T cells. This 
      DC specific ability, called cross-presentation (CP), is important for the 
      activation of cell-mediated immunity and the induction of self-tolerance. Recent 
      research revealed that endoplasmic reticulum-associated degradation (ERAD), which 
      was first identified as a part of the unfolded protein response-a quality control 
      system in the ER-plays a pivotal role in the processing of exogenous proteins in 
      CP. Moreover, DCs express a variety of immuno-modulatory molecules and cytokines 
      to regulate T cell activation in response to the environment. Although both CP 
      and immuno-modulation are indispensable, contrasting ER conditions are required 
      for their correct activity. Since ERAD substrates are unfolded proteins, their 
      accumulation may result in ER stress, impaired cell homeostasis, and eventually 
      apoptosis. In contrast, activation of the unfolded protein response should be 
      inhibited for DCs to express immuno-modulatory molecules and cytokines. Here, we 
      review recent advances on antigen CP, focusing on intracellular transport routes 
      for exogenous antigens and distinctive subcellular compartments involved in ERAD.
FAU - Imai, Jun
AU  - Imai J
AD  - Laboratory of Physiological Chemistry, Faculty of Pharmacy, Takasaki University 
      of Health and Welfare, Takasaki, Gunma 370-0033, Japan.
FAU - Otani, Mayu
AU  - Otani M
AD  - Laboratory of Physiological Chemistry, Faculty of Pharmacy, Takasaki University 
      of Health and Welfare, Takasaki, Gunma 370-0033, Japan.
FAU - Sakai, Takahiro
AU  - Sakai T
AD  - Laboratory of Physiological Chemistry, Faculty of Pharmacy, Takasaki University 
      of Health and Welfare, Takasaki, Gunma 370-0033, Japan.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20191109
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Animals
MH  - *Antigen Presentation
MH  - CD8-Positive T-Lymphocytes/*immunology
MH  - Cross-Priming
MH  - Dendritic Cells/*immunology
MH  - Endoplasmic Reticulum-Associated Degradation
MH  - Histocompatibility Antigens Class I/immunology
MH  - Humans
MH  - Inflammation/immunology
PMC - PMC6888166
OTO - NOTNLM
OT  - cross-presentation
OT  - dendritic cells
OT  - endoplasmic reticulum-associated degradation
OT  - inflammation
OT  - major histocompatibility class I
OT  - unfolded protein response
COIS- The authors declare no conflict of interest.
EDAT- 2019/11/14 06:00
MHDA- 2020/04/04 06:00
PMCR- 2019/11/01
CRDT- 2019/11/14 06:00
PHST- 2019/08/26 00:00 [received]
PHST- 2019/10/29 00:00 [revised]
PHST- 2019/11/06 00:00 [accepted]
PHST- 2019/11/14 06:00 [entrez]
PHST- 2019/11/14 06:00 [pubmed]
PHST- 2020/04/04 06:00 [medline]
PHST- 2019/11/01 00:00 [pmc-release]
AID - ijms20225606 [pii]
AID - ijms-20-05606 [pii]
AID - 10.3390/ijms20225606 [doi]
PST - epublish
SO  - Int J Mol Sci. 2019 Nov 9;20(22):5606. doi: 10.3390/ijms20225606.