PMID- 31718837
OWN - NLM
STAT- MEDLINE
DCOM- 20200221
LR  - 20200221
IS  - 1873-7072 (Electronic)
IS  - 0308-8146 (Linking)
VI  - 309
DP  - 2020 Mar 30
TI  - Application of a multiclass screening method for veterinary drugs and pesticides 
      using HPLC-QTOF-MS in egg samples.
PG  - 125746
LID - S0308-8146(19)31877-1 [pii]
LID - 10.1016/j.foodchem.2019.125746 [doi]
AB  - A multi-class screening method for the determination of veterinary drugs and 
      pesticides in eggs was developed by high performance liquid chromatography 
      quadrupole-time-of-flight mass spectrometry (HPLC-QTOF-MS). A single-injection 
      workflow was developed for qualitative analysis, and method validation was 
      conducted in terms of retention time deviation (DeltaRt), exact mass error (Deltam), 
      selectivity, specificity, precision and trueness. The characteristic fragment 
      ions in information dependent acquisition (IDA) mode were summarized for 
      retrospective and non-target screening. Five of 70 samples were found positive 
      with sulfachloropyridazine, sulfamonomethoxine and fipronil sulfone. Compared 
      with triple-quadrupole (QqQ) MS method, the obtained results showed that QTOF-MS 
      gave comparable results to QqQ-MS with residue concentrations higher than 
      10 mug.kg(-1), whereas QqQ-MS was more powerful at lower concentrations 
      (<1 mug.kg(-1)). Moreover, the amount of fragment ions acquired by HPLC-QTOF-MS 
      decreased substantially at trace levels, which may be a potential cause of 
      reduced reliability of identification.
CI  - Copyright (c) 2019 Elsevier Ltd. All rights reserved.
FAU - Hou, Xue
AU  - Hou X
AD  - Center of Analysis and Testing, Sichuan Academy of Agricultural Sciences, Chengdu 
      610066, China; Laboratory of Quality and Safety Risk Assessment for Agro-products 
      (Chengdu), Ministry of Agriculture, Chengdu 610066, China.
FAU - Xu, Xu
AU  - Xu X
AD  - Center of Analysis and Testing, Sichuan Academy of Agricultural Sciences, Chengdu 
      610066, China; Chengdu Institute of Organic Chemistry, Chinese Academy of 
      Sciences, Chengdu 610041, China; University of Chinese Academy of Sciences, 
      Beijing 100039, China. Electronic address: xuxu5286@126.com.
FAU - Xu, Xiaoying
AU  - Xu X
AD  - Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 
      610041, China.
FAU - Han, Mei
AU  - Han M
AD  - Center of Analysis and Testing, Sichuan Academy of Agricultural Sciences, Chengdu 
      610066, China; Laboratory of Quality and Safety Risk Assessment for Agro-products 
      (Chengdu), Ministry of Agriculture, Chengdu 610066, China.
FAU - Qiu, Shiting
AU  - Qiu S
AD  - Center of Analysis and Testing, Sichuan Academy of Agricultural Sciences, Chengdu 
      610066, China; Laboratory of Quality and Safety Risk Assessment for Agro-products 
      (Chengdu), Ministry of Agriculture, Chengdu 610066, China.
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20191023
PL  - England
TA  - Food Chem
JT  - Food chemistry
JID - 7702639
RN  - 0 (Pesticides)
RN  - 0 (Veterinary Drugs)
SB  - IM
MH  - Animals
MH  - Chickens
MH  - Chromatography, High Pressure Liquid/*methods
MH  - Eggs/*analysis
MH  - Food Contamination/*analysis
MH  - Pesticides/*analysis
MH  - Sensitivity and Specificity
MH  - Tandem Mass Spectrometry/*methods
MH  - Veterinary Drugs/*analysis
OTO - NOTNLM
OT  - Eggs
OT  - HPLC-QTOF-MS
OT  - HPLC-QqQ-MS
OT  - Multiclass residues
OT  - Target screening
EDAT- 2019/11/14 06:00
MHDA- 2020/02/23 06:00
CRDT- 2019/11/14 06:00
PHST- 2019/01/28 00:00 [received]
PHST- 2019/10/03 00:00 [revised]
PHST- 2019/10/19 00:00 [accepted]
PHST- 2019/11/14 06:00 [pubmed]
PHST- 2020/02/23 06:00 [medline]
PHST- 2019/11/14 06:00 [entrez]
AID - S0308-8146(19)31877-1 [pii]
AID - 10.1016/j.foodchem.2019.125746 [doi]
PST - ppublish
SO  - Food Chem. 2020 Mar 30;309:125746. doi: 10.1016/j.foodchem.2019.125746. Epub 2019 
      Oct 23.