PMID- 31720909
OWN - NLM
STAT- MEDLINE
DCOM- 20200316
LR  - 20200316
IS  - 1534-312X (Electronic)
IS  - 1522-8037 (Linking)
VI  - 21
IP  - 10
DP  - 2019 Nov 13
TI  - Functional Dyspepsia in the Elderly.
PG  - 54
LID - 10.1007/s11894-019-0722-5 [doi]
AB  - PURPOSE OF REVIEW: Functional dyspepsia is a common condition, and the condition 
      is defined by symptoms using Rome IV criteria. This review addresses the issue of 
      functional dyspepsia in elderly patients, epidemiology, investigation, and 
      treatment. RECENT FINDINGS: Recent studies show that while the prevalence of 
      dyspepsia declines in the elderly, it is still prevalant investigations to 
      confirm the diagnosis (including mandatory upper gastrointestinal endoscopy) must 
      exclude organic disease. These include ulcers (particularly associated with 
      nonsteroidal antiinflammatory drugs), Helicobacter pylori pathologies, cancer, 
      coeliac disease, and autoimmune gastritis. Recent research is unraveling 
      pathophysiology beyond symptom-only definitions, focusing on the duodenum with 
      innate immune disturbance (duodenal eosinophilia) and microbial disruption as 
      possible cause. Management of functional dyspepsia includes making a secure 
      diagnosis, treatment with first-line proton pump inhibitors (PPI), then tricyclic 
      antidepressants, and careful choice of prokinetics. Herbal treatments (peppermint 
      oil) and STW-5 have in this age group limited efficacy. Further studies are 
      needed to define the prevalence of functional dyspepsia in the elderly and of 
      prime importance, to exclude organic disease as a cause for symptoms of 
      dyspepsia.
FAU - Walker, Marjorie M
AU  - Walker MM
AD  - Faculty of Health & Medicine, University of Newcastle, Callaghan, 2305, NSW, 
      Australia.
AD  - Australian Gastrointestinal Research Alliance (AGIRA), Callaghan, 2305, NSW, 
      Australia.
FAU - Talley, Nicholas J
AU  - Talley NJ
AD  - Faculty of Health & Medicine, University of Newcastle, Callaghan, 2305, NSW, 
      Australia. Nicholas.Talley@newcastle.edu.au.
AD  - Australian Gastrointestinal Research Alliance (AGIRA), Callaghan, 2305, NSW, 
      Australia. Nicholas.Talley@newcastle.edu.au.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20191113
PL  - United States
TA  - Curr Gastroenterol Rep
JT  - Current gastroenterology reports
JID - 100888896
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Aged
MH  - Aging/physiology
MH  - Anti-Inflammatory Agents, Non-Steroidal/adverse effects
MH  - Dyspepsia/drug therapy/epidemiology/*etiology
MH  - Helicobacter Infections/complications
MH  - Helicobacter pylori
MH  - Humans
MH  - Prevalence
MH  - Proton Pump Inhibitors/therapeutic use
MH  - Stomach/physiopathology
MH  - Stomach Neoplasms/complications/diagnosis
OTO - NOTNLM
OT  - Aging
OT  - Duodenum
OT  - Dyspepsia
OT  - Eosinophil
OT  - Microbiome
OT  - Pathology
OT  - Stomach
EDAT- 2019/11/14 06:00
MHDA- 2020/03/17 06:00
CRDT- 2019/11/14 06:00
PHST- 2019/11/14 06:00 [entrez]
PHST- 2019/11/14 06:00 [pubmed]
PHST- 2020/03/17 06:00 [medline]
AID - 10.1007/s11894-019-0722-5 [pii]
AID - 10.1007/s11894-019-0722-5 [doi]
PST - epublish
SO  - Curr Gastroenterol Rep. 2019 Nov 13;21(10):54. doi: 10.1007/s11894-019-0722-5.