PMID- 31722589
OWN - NLM
STAT- MEDLINE
DCOM- 20201204
LR  - 20210110
IS  - 1471-1788 (Electronic)
IS  - 1365-1501 (Print)
IS  - 1365-1501 (Linking)
VI  - 24
IP  - 1
DP  - 2020 Mar
TI  - Neurocognitive findings in young adults with binge eating disorder.
PG  - 71-76
LID - 10.1080/13651501.2019.1687724 [doi]
AB  - Objectives: Binge-eating disorder (BED) has been associated with cognitive 
      impairment, including on measures of impulsivity, but it is not clear in prior 
      literature whether these deficits may have been associated with obesity, rather 
      than BED per se. Impulsivity may play a role in predisposing people towards BED 
      as well as in the chronicity of symptoms. The aim of this study was to examine 
      cognitive functions between BED and healthy controls matched for age, gender, and 
      body mass indices.Methods: Individuals with BED and healthy controls were 
      recruited from the general community using media advertisements. After providing 
      informed consent, study participants completed a clinical interview and 
      computerised neuropsychological testing. Group differences were analysed.Results: 
      Groups did not differ significantly on age, gender, education levels, or body 
      mass indices. The BED group (N = 17) exhibited significantly impaired stop-signal 
      response inhibition (Stop-Signal Task) and executive planning (Stockings of 
      Cambridge Task) compared to healthy controls (N = 17). Spatial working memory and 
      set-shifting were intact.Discussion: BED appears to be associated with motor 
      disinhibition and impaired executive planning even controlling for obesity. 
      Longitudinal work is needed to clarify whether motor impulsivity predisposes 
      people to BED, and/or contributes to persistence of symptoms over time.Key 
      pointsBinge-eating disorder is common, under-recognised, and associated with 
      untoward physical and health sequelae.The neurobiological basis of binge-eating 
      disorder is unclear; cognitive testing may offer insights.Many prior cognitive 
      studies have not controlled for potential confounds, especially group differences 
      in body mass indices (BMI). Obesity in itself has been linked with cognitive 
      dysfunction.Here, we compared cognition between people with binge-eating disorder 
      and controls, matched for BMI and other measures.Binge-eating disorder was 
      associated with impaired response inhibition and executive planning.These results 
      inform neurobiological models of binge-eating disorder and may suggest new 
      treatment targets for this condition.
FAU - Grant, Jon E
AU  - Grant JE
AD  - Department of Psychiatry and Behavioral Neuroscience, University of Chicago, 
      Pritzker School of Medicine, Chicago, IL, USA.
FAU - Chamberlain, Samuel R
AU  - Chamberlain SR
AUID- ORCID: 0000-0001-7014-8121
AD  - Department of Psychiatry, University of Cambridge, Cambridge, UK.
AD  - Cambridge and Peterborough NHS Foundation Trust, Fulbourn, UK.
LA  - eng
GR  - WT_/Wellcome Trust/United Kingdom
GR  - 110049/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
DEP - 20191114
PL  - England
TA  - Int J Psychiatry Clin Pract
JT  - International journal of psychiatry in clinical practice
JID - 9709509
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Binge-Eating Disorder/complications/*physiopathology
MH  - Cognitive Dysfunction/etiology/*physiopathology
MH  - *Executive Function
MH  - Female
MH  - Humans
MH  - *Inhibition, Psychological
MH  - Male
MH  - Young Adult
PMC - PMC7100552
MID - EMS84861
OTO - NOTNLM
OT  - Impulsivity
OT  - addiction
OT  - binge
OT  - compulsivity
OT  - food
EDAT- 2019/11/15 06:00
MHDA- 2020/12/15 06:00
PMCR- 2020/04/02
CRDT- 2019/11/15 06:00
PHST- 2019/11/15 06:00 [pubmed]
PHST- 2020/12/15 06:00 [medline]
PHST- 2019/11/15 06:00 [entrez]
PHST- 2020/04/02 00:00 [pmc-release]
AID - 1687724 [pii]
AID - 10.1080/13651501.2019.1687724 [doi]
PST - ppublish
SO  - Int J Psychiatry Clin Pract. 2020 Mar;24(1):71-76. doi: 
      10.1080/13651501.2019.1687724. Epub 2019 Nov 14.