PMID- 31722595
OWN - NLM
STAT- MEDLINE
DCOM- 20201214
LR  - 20201214
IS  - 1744-5086 (Electronic)
IS  - 0928-6586 (Linking)
VI  - 27
IP  - 1
DP  - 2020 Feb
TI  - Rationale, Design, Methodology and Baseline Data of Fushun Diabetic Retinopathy 
      Cohort Study (FS-DIRECT).
PG  - 73-82
LID - 10.1080/09286586.2019.1680702 [doi]
AB  - Purpose: To describe the rationale, design, methodology and baseline 
      characteristics of Fushun Diabetic Retinopathy Cohort Study (FS-DIRECT), a 
      community-based prospective cohort study in patients with type 2 diabetes 
      mellitus (T2DM) living in northeast China.Methods: Patients with T2DM, aged 30 
      years and above from communities of Fushun city, Liaoning province, China, were 
      recruited. The presence and severity of the diabetic retinopathy (DR) were 
      determined by a modified Early Treatment Diabetic Retinopathy Study (ETDRS) 
      retinopathy scale of 6 fields fundus photographs. Detailed ocular examinations 
      and questionnaires were collated, in addition to blood and urine sample 
      collection.Results: Of the 2224 subjects eligible for the FS-DIRECT, 2033 (91.4%) 
      participated in the study. The majority of participants were female (58.9%), the 
      average age was 62.1 +/- 9.1 years. The overall prevalence rates of DR, 
      non-proliferative DR, proliferative DR, diabetic macular edema, and 
      vision-threatening retinopathy were 44.3%, 40.0%, 4.3%, 15.2%, and 12.3%, 
      respectively. Compared to the patients without DR, patients with DR had lower 
      income, an earlier onset of diabetes, a longer duration of diabetes, higher 
      proportion of insulin use, higher fasting plasma glucose, HbA1c, systolic blood 
      pressure, total cholesterol and high density lipoprotein, as well as a higher 
      level of urine protein (all P < .05).Conclusion: The baseline data of FS-DIRECT 
      showed a high prevalence of DR in a community of northeast China. Further 
      investigation will provide key information about the risk factors, impact, and 
      trends of DR in this region.
FAU - Wang, Yu
AU  - Wang Y
AD  - Fushun Eye Hospital, Fushun, Liaoning, China.
FAU - Lin, Zhong
AU  - Lin Z
AD  - School of Ophthalmology & Optometry, Wenzhou Medical University, Eye Hospital of 
      Wenzhou Medical University, Wenzhou, China.
FAU - Wen, Liang
AU  - Wen L
AD  - Fushun Eye Hospital, Fushun, Liaoning, China.
FAU - Rong, Shi Song
AU  - Rong SS
AD  - Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, 
      Boston, MA, USA.
FAU - Ding, Xiao Xia
AU  - Ding XX
AD  - Fushun Eye Hospital, Fushun, Liaoning, China.
FAU - Li, Dong
AU  - Li D
AD  - Fushun Eye Hospital, Fushun, Liaoning, China.
FAU - Feng, Ke Mi
AU  - Feng KM
AD  - School of Ophthalmology & Optometry, Wenzhou Medical University, Eye Hospital of 
      Wenzhou Medical University, Wenzhou, China.
FAU - Wang, Feng Hua
AU  - Wang FH
AD  - Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University; 
      Beijing Ophthalmology & Visual Science Key Lab, Beijing, China.
FAU - Liang, Yuan Bo
AU  - Liang YB
AD  - School of Ophthalmology & Optometry, Wenzhou Medical University, Eye Hospital of 
      Wenzhou Medical University, Wenzhou, China.
FAU - Zhai, Gang
AU  - Zhai G
AD  - Fushun Eye Hospital, Fushun, Liaoning, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20191113
PL  - England
TA  - Ophthalmic Epidemiol
JT  - Ophthalmic epidemiology
JID - 9435674
SB  - IM
MH  - Aged
MH  - China/epidemiology
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 2/blood/*complications/urine
MH  - Diabetic Retinopathy/*diagnosis/*epidemiology/etiology
MH  - Female
MH  - Fundus Oculi
MH  - Humans
MH  - Macular Edema/diagnosis/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Photography/methods
MH  - Prevalence
MH  - Prospective Studies
MH  - Risk Factors
MH  - Severity of Illness Index
OTO - NOTNLM
OT  - cohort study
OT  - community-based study
OT  - diabetes mellitus
OT  - diabetic retinopathy
OT  - risk factors
EDAT- 2019/11/15 06:00
MHDA- 2020/12/15 06:00
CRDT- 2019/11/15 06:00
PHST- 2019/11/15 06:00 [pubmed]
PHST- 2020/12/15 06:00 [medline]
PHST- 2019/11/15 06:00 [entrez]
AID - 10.1080/09286586.2019.1680702 [doi]
PST - ppublish
SO  - Ophthalmic Epidemiol. 2020 Feb;27(1):73-82. doi: 10.1080/09286586.2019.1680702. 
      Epub 2019 Nov 13.