PMID- 31722957
OWN - NLM
STAT- MEDLINE
DCOM- 20210713
LR  - 20210713
IS  - 1708-8267 (Electronic)
IS  - 1081-5589 (Linking)
VI  - 68
IP  - 3
DP  - 2020 Mar
TI  - Assessment of two novel renal tubular proteins in type 2 diabetic patients with 
      nephropathy.
PG  - 748-755
LID - 10.1136/jim-2019-001135 [doi]
AB  - Nephropathy is a common health issue associated with type 2 diabetes mellitus 
      (T2DM). Treatment of diabetic nephropathy (DN) in an early stage can effectively 
      inhibit its progression. Albuminuria is the currently accepted marker for 
      detection of DN.This study aims to evaluate the urinary level of two novel renal 
      tubular proteins (cyclophilin A and periostin) in patients with T2DM and among 
      different nephropathy stages and also to validate the diagnostic accuracy of both 
      cyclophilin A and periostin as potential markers for early prediction of DN 
      relative to albuminuria.This cross-sectional study recruited 137 patients with 
      T2DM, and they were divided based on their urinary albumin:creatinine ratio into 
      T2DM with normoalbuminuria (group II), incipient T2DN with microalbuminuria 
      (group III) and overt T2DN with macroalbuminuria (groupIV) beside 41 healthy 
      subjects as group I Cyclophilin A and periostin were measured in the urine using 
      ELISA. Diagnostic accuracy of both markers was determined for prediction of DN 
      via receiver operating characteristic curve analyses.Urinary cyclophilin A and 
      periostin levels were significantly higher in DN groups when compared with T2DM 
      with normoalbuminuria group. For prediction of incipient and overt DN, areas 
      under the curve (AUCs) of periostin were 0.954, 0.997 and cyclophilin A were 
      0.914, 0.937, respectively. AUCs of periostin were higher than that for 
      cyclophilin A with a significant AUC difference (p=0.022) in overt DN 
      stage.Periostin and cyclophilin A could be regarded as a potential urinary 
      biomarker for early prediction of DN. Periostin exhibits a higher diagnostic 
      accuracy than urinary cyclophilin A specifically in overt DN stage.
CI  - (c) American Federation for Medical Research 2020. No commercial re-use. See rights 
      and permissions. Published by BMJ.
FAU - Abdel Ghafar, Muhammad Tarek
AU  - Abdel Ghafar MT
AUID- ORCID: 0000-0002-0621-4291
AD  - Clinical Pathology, Tanta University Faculty of Medicine, Tanta, Egypt 
      mohammedtarek5514@yahoo.com.
FAU - Shalaby, Khaled Hamed
AU  - Shalaby KH
AD  - Internal Medicine, Tanta University Faculty of Medicine, Tanta, Egypt.
FAU - Okda, Hanaa Ibrahim
AU  - Okda HI
AD  - Internal Medicine, Tanta University Faculty of Medicine, Tanta, Egypt.
FAU - Abo El Gheit, Rehab E
AU  - Abo El Gheit RE
AD  - Physiology, Tanta University Faculty of Medicine, Tanta, Egypt.
FAU - Soliman, Nema Ali
AU  - Soliman NA
AD  - Medical Biochemistry, Tanta University Faculty of Medicine, Tanta, Egypt.
FAU - Keshk, Walaa Arafa
AU  - Keshk WA
AD  - Medical Biochemistry, Tanta University Faculty of Medicine, Tanta, Egypt.
LA  - eng
PT  - Journal Article
DEP - 20191112
PL  - England
TA  - J Investig Med
JT  - Journal of investigative medicine : the official publication of the American 
      Federation for Clinical Research
JID - 9501229
RN  - 0 (Biomarkers)
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (POSTN protein, human)
RN  - AYI8EX34EU (Creatinine)
RN  - EC 5.2.1.- (Cyclophilin A)
SB  - IM
MH  - Albuminuria
MH  - Biomarkers/urine
MH  - Cell Adhesion Molecules/*urine
MH  - Creatinine/urine
MH  - Cross-Sectional Studies
MH  - Cyclophilin A/*urine
MH  - Diabetes Mellitus, Type 2/*urine
MH  - Diabetic Nephropathies/diagnosis/*urine
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - ROC Curve
MH  - Retrospective Studies
MH  - Sensitivity and Specificity
OTO - NOTNLM
OT  - Diabetes Complications
OT  - Diabetes Mellitus
OT  - Diabetic Nephropathies
OT  - Proteinuria
OT  - diagnostic tests, routine
COIS- Competing interests: None declared.
EDAT- 2019/11/15 06:00
MHDA- 2021/07/14 06:00
CRDT- 2019/11/15 06:00
PHST- 2019/10/19 00:00 [accepted]
PHST- 2019/11/15 06:00 [pubmed]
PHST- 2021/07/14 06:00 [medline]
PHST- 2019/11/15 06:00 [entrez]
AID - jim-2019-001135 [pii]
AID - 10.1136/jim-2019-001135 [doi]
PST - ppublish
SO  - J Investig Med. 2020 Mar;68(3):748-755. doi: 10.1136/jim-2019-001135. Epub 2019 
      Nov 12.