PMID- 31723722
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220411
IS  - 2474-1264 (Print)
IS  - 2474-1272 (Electronic)
IS  - 2474-1264 (Linking)
VI  - 3
IP  - 5
DP  - 2019 Sep
TI  - Percentage of Foveal vs Total Macular Geographic Atrophy as a Predictor of Visual 
      Acuity in Age-Related Macular Degeneration.
PG  - 278-282
LID - 10.1177/2474126419859454 [doi]
AB  - PURPOSE: This article investigates the relationship between visual acuity (VA), 
      total area of geographic atrophy (GA), and percentage of foveal GA. METHODS: A 
      multicenter, retrospective, cross-sectional study was conducted of patients with 
      GA due to age-related macular degeneration. Demographics, VA, fundus 
      autofluorescence (FAF), and spectral-domain optical coherence tomography (SD-OCT) 
      images were collected. Using FAF images aided by SD-OCT, fovea-sparing status, GA 
      pattern, total GA size, and percentage of GA covering the foveal area-within a 
      1.5-mm-diameter circle centered on the fovea centralis-were assessed. Univariable 
      and multiple linear regression analyses were performed. RESULTS: Fifty-four eyes 
      (mean age, 78.7 +/-7.7 years [SD], 60.0% female) were studied. Mean VA was 0.8 +/- 
      0.6 logarithm of the minimum angle of resolution (Snellen equivalent 20/126 +/- 
      20/80), mean total GA 8.8 +/- 6.7 mm(2), and mean percentage of foveal GA was 71.5 
      +/- 30.9%. Of all assessed eyes, 48.2% (n = 26) presented with multifocal GA, and 
      18.5% (n =10) had foveal sparing. Multiple regression analysis revealed that, 
      controlling for age and GA pattern, the percentage of foveal GA presented a 
      statistically significant association with VA (ss =0.41, P = .004). No significant 
      associations were observed with mean total GA size, while controlling for the 
      same variables (ss=0.010, P = .440). CONCLUSIONS: Percentage of foveal GA was 
      significantly associated with VA impairment, although the same was not verified 
      for total GA area. These findings suggest that percentage of foveal GA may 
      represent a more useful tool for assessing the impact of GA on VA. Further 
      validation is needed in larger cohorts.
FAU - Bagheri, Saghar
AU  - Bagheri S
AUID- ORCID: 0000-0002-5165-5811
AD  - Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, 
      Boston, MA, USA.
FAU - Lains, Ines
AU  - Lains I
AD  - Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, 
      Boston, MA, USA.
FAU - Silverman, Rebecca F
AU  - Silverman RF
AD  - Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, 
      Boston, MA, USA.
FAU - Kim, Ivana
AU  - Kim I
AD  - Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, 
      Boston, MA, USA.
FAU - Eliott, Dean
AU  - Eliott D
AD  - Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, 
      Boston, MA, USA.
FAU - Silva, Rufino
AU  - Silva R
AD  - Department of Ophthalmology, Centro Hospitalar e Universitario de Coimbra, 
      Coimbra, Portugal.
AD  - Faculty of Medicine, University of Coimbra, and Association for Innovation and 
      Biomedical Research on Light and Image, Coimbra, Portugal.
FAU - Miller, John
AU  - Miller J
AD  - Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, 
      Boston, MA, USA.
FAU - Husain, Deeba
AU  - Husain D
AD  - Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, 
      Boston, MA, USA.
FAU - Miller, Joan W
AU  - Miller JW
AD  - Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, 
      Boston, MA, USA.
FAU - Saad, Leonide
AU  - Saad L
AD  - Harkness Eye Institute, Columbia University Medical Center, New York, NY, USA.
AD  - Alkeus Pharmaceuticals, Boston, MA, USA.
FAU - Vavvas, Demetrios G
AU  - Vavvas DG
AD  - Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, 
      Boston, MA, USA.
LA  - eng
GR  - R01 EY025362/EY/NEI NIH HHS/United States
GR  - R13 EY029551/EY/NEI NIH HHS/United States
GR  - R21 EY023079/EY/NEI NIH HHS/United States
PT  - Journal Article
DEP - 20190822
PL  - United States
TA  - J Vitreoretin Dis
JT  - Journal of vitreoretinal diseases
JID - 101700301
PMC - PMC6853618
MID - NIHMS1047808
OTO - NOTNLM
OT  - OCT
OT  - dry AMD (nonneovascular)
OT  - fovea
OT  - fundus autofluorescence
OT  - geographic atrophy
OT  - imaging
OT  - macula
EDAT- 2019/11/15 06:00
MHDA- 2019/11/15 06:01
PMCR- 2019/11/13
CRDT- 2019/11/15 06:00
PHST- 2019/11/15 06:00 [entrez]
PHST- 2019/11/15 06:00 [pubmed]
PHST- 2019/11/15 06:01 [medline]
PHST- 2019/11/13 00:00 [pmc-release]
AID - 10.1177/2474126419859454 [doi]
PST - ppublish
SO  - J Vitreoretin Dis. 2019 Sep;3(5):278-282. doi: 10.1177/2474126419859454. Epub 
      2019 Aug 22.